Table 1. Summary of the data on the different mutant mice.
| Mouse strain | Growth of M. avium | Granulomas | Necrosis |
|---|---|---|---|
| C57BL/6 (B6) | Well structured | Present | |
| B6-Nu/Cφ | Well structured | Present | |
| B6-Nu/Nu | Increased* | Poorly structured† | Absent |
| B6-CD4−/− | Increased* | Poorly structured† | Absent |
| B6-CD8α−/− | Similar to control* | Well structured | Present |
| B6-TCRδ−/− | Similar to control* | Well structured | Present |
| B6-CD54−/− | Similar to control* | Well structured | Reduced‡ |
| B6-CD40−/− | Similar to control* | Poorly structured | Absent |
| B6-IL12p40−/− | Similar to control* | Incipient† | Absent |
| B6-IFNγ−/− | Increased* | Incipient | Absent |
| B6-TNFRp55+/− | Similar to control* | Well structured | Present |
| B6-IL6−/− | Similar to control* | Well structured | Reduced‡ |
| B6-IL10−/− | Reduced* | Well structured | Reduced§ |
| B6-perforin−/− | Similar to control* | Well structured | Present |
| B6-iNOS−/− | Reduced* | Well structured | Present¶ |
| B6+/bcl2 | Similar to control* | Well structured | Present |
*
The Student's t-test was used to analyse the statistical significance of the differences. Only statistically significant increases or decreases in viable counts are reported in this table.
†
Incipient granulomas were mostly formed by few heavily infected macrophages with little or no lymphoid involvement. Poorly structured granulomas had less lymphoid cuffing than granulomas of control mice.
‡
Reduction in necrosis was observed both as a reduction in the number of lesions per organ and the occurrence of a percentage of the mice which totally lacked necrotic lesions.
§
The lesions showed necrosis later than control mice.
¶
The lesions were fewer in number but bigger in size.