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. 2003 Feb;108(2):230–237. doi: 10.1046/j.1365-2567.2003.01571.x

Figure 5.

Figure 5

Regulation by cytokines of splenic cell nitrite production in C57BL/6 IL-12 knockout and wild-type C57BL/6 mice infected with T. cruzi. Cultures were performed on days 7 and 14 after infection and stimulated with parasite-antigen, T-Ag. At the beginning of the cultures the neutralizing anti-cytokine mAbs, anti-IL-10, anti-IL-4 and anti-TNF-α, were added; GL.113 was used as isotype control mAb. The supernatants were harvested after 72 hr and nitrite was measured by the Griess reaction. Results are expressed as the arithmetic means from duplicates ± SD. *P < 0·05. The results are representative of three experiments.