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Serum immunoglobulin G1 (IgG1) (a) and IgG2a (b) levels measured by isotype-specific ensyme-linked immunosorbent assay (ELISA) in 8–26-week-old IL-2−/− and IL-2+/+ mice. The numbers of mice in each group are as follows. IL-2−/−: 8 weeks, n = 4; 12 weeks, n = 3; 26 weeks, n = 4. IL-2+/+: 8 weeks, n = 7; 12 weeks, n = 4; 26 weeks, n = 5. Values represent mean ± SD (in µg/ml) of each isotype, measured in sera collected from mice at the different ages shown.
