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. 1996 Oct;178(19):5850–5852. doi: 10.1128/jb.178.19.5850-5852.1996

The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans.

C San José 1, R A Monge 1, R Pérez-Díaz 1, J Pla 1, C Nombela 1
PMCID: PMC178437  PMID: 8824643

Abstract

The Candida albicans HOG1 gene (HOG1CA) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 delta mutants. HOG1CA codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media.

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Selected References

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