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. 2001;9(4):239–244. doi: 10.1155/S1064744901000394

The Inhibitory Effect of Clindamycin on Lactobacillus in vitro

Alla Aroutcheva 1,✉, Jose A Simoes 1, Susan Shott 1, Sebastian Faro 2
PMCID: PMC1784659  PMID: 11916182

Abstract

Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobacillus spp.

Methods: Concentrations of clindamycin ranging from 1.95–20 000 mg/ml were studied for their effect on the growth of six strains of Lactobacillus .

Results: Clindamycin concentrations between 1.95–31.25 mg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 mg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1000 mg/ml.

Conclusion: High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus .

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Selected References

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