Abstract
Mycobacterium avium secretes iron-binding siderophores called exochelins. The exochelins from M. avium have previously been reported to have unsaturated side chains that terminate in carboxylic acid. In contrast, our data show the side chains to be both saturated and unsaturated and to terminate with either a carboxylate or methyl ester.
Full Text
The Full Text of this article is available as a PDF (218.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barclay R., Ewing D. F., Ratledge C. Isolation, identification, and structural analysis of the mycobactins of Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium scrofulaceum, and Mycobacterium paratuberculosis. J Bacteriol. 1985 Nov;164(2):896–903. doi: 10.1128/jb.164.2.896-903.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barclay R., Ratledge C. Mycobactins and exochelins of Mycobacterium tuberculosis, M. bovis, M. africanum and other related species. J Gen Microbiol. 1988 Mar;134(3):771–776. doi: 10.1099/00221287-134-3-771. [DOI] [PubMed] [Google Scholar]
- Gobin J., Horwitz M. A. Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall. J Exp Med. 1996 Apr 1;183(4):1527–1532. doi: 10.1084/jem.183.4.1527. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gobin J., Moore C. H., Reeve J. R., Jr, Wong D. K., Gibson B. W., Horwitz M. A. Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc Natl Acad Sci U S A. 1995 May 23;92(11):5189–5193. doi: 10.1073/pnas.92.11.5189. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Inderlied C. B., Kemper C. A., Bermudez L. E. The Mycobacterium avium complex. Clin Microbiol Rev. 1993 Jul;6(3):266–310. doi: 10.1128/cmr.6.3.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macham L. P., Ratledge C., Nocton J. C. Extracellular iron acquisition by mycobacteria: role of the exochelins and evidence against the participation of mycobactin. Infect Immun. 1975 Dec;12(6):1242–1251. doi: 10.1128/iai.12.6.1242-1251.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sharman G. J., Williams D. H., Ewing D. F., Ratledge C. Determination of the structure of exochelin MN, the extracellular siderophore from Mycobacterium neoaurum. Chem Biol. 1995 Aug;2(8):553–561. doi: 10.1016/1074-5521(95)90189-2. [DOI] [PubMed] [Google Scholar]
- Sharman G. J., Williams D. H., Ewing D. F., Ratledge C. Isolation, purification and structure of exochelin MS, the extracellular siderophore from Mycobacterium smegmatis. Biochem J. 1995 Jan 1;305(Pt 1):187–196. doi: 10.1042/bj3050187. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Snow G. A. Mycobactins: iron-chelating growth factors from mycobacteria. Bacteriol Rev. 1970 Jun;34(2):99–125. doi: 10.1128/br.34.2.99-125.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]