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. 1996 Nov;178(22):6628–6631. doi: 10.1128/jb.178.22.6628-6631.1996

The Myxococcus xanthus developmentally expressed asgB-dependent genes can be targets of the A signal-generating or A signal-responding pathway.

M G Bowden 1, H B Kaplan 1
PMCID: PMC178551  PMID: 8932321

Abstract

Functional Myxococcus xanthus A signal-generating and A signal-responding pathways are required for the progression through early multicellular development. To identify genes responsive to these pathways, the expression of eight early developmental genes was analyzed. This examination identified one gene as a target of the A signal-generating pathway and four genes as targets of the A signal-responding pathway.

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Selected References

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  1. Davis J. M., Mayor J., Plamann L. A missense mutation in rpoD results in an A-signalling defect in Myxococcus xanthus. Mol Microbiol. 1995 Dec;18(5):943–952. doi: 10.1111/j.1365-2958.1995.18050943.x. [DOI] [PubMed] [Google Scholar]
  2. Downard J. S., Zusman D. R. Differential expression of protein S genes during Myxococcus xanthus development. J Bacteriol. 1985 Mar;161(3):1146–1155. doi: 10.1128/jb.161.3.1146-1155.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Fuqua W. C., Winans S. C., Greenberg E. P. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J Bacteriol. 1994 Jan;176(2):269–275. doi: 10.1128/jb.176.2.269-275.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gulati P., Xu D., Kaplan H. B. Identification of the minimum regulatory region of a Myxococcus xanthus A-signal-dependent developmental gene. J Bacteriol. 1995 Aug;177(16):4645–4651. doi: 10.1128/jb.177.16.4645-4651.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Guo D., Bowden M. G., Pershad R., Kaplan H. B. The Myxococcus xanthus rfbABC operon encodes an ATP-binding cassette transporter homolog required for O-antigen biosynthesis and multicellular development. J Bacteriol. 1996 Mar;178(6):1631–1639. doi: 10.1128/jb.178.6.1631-1639.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hagen D. C., Bretscher A. P., Kaiser D. Synergism between morphogenetic mutants of Myxococcus xanthus. Dev Biol. 1978 Jun;64(2):284–296. doi: 10.1016/0012-1606(78)90079-9. [DOI] [PubMed] [Google Scholar]
  7. Kaiser D. Bacteria also vote. Science. 1996 Jun 14;272(5268):1598–1599. doi: 10.1126/science.272.5268.1598. [DOI] [PubMed] [Google Scholar]
  8. Kaplan H. B., Kuspa A., Kaiser D. Suppressors that permit A-signal-independent developmental gene expression in Myxococcus xanthus. J Bacteriol. 1991 Feb;173(4):1460–1470. doi: 10.1128/jb.173.4.1460-1470.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kaplan H. B., Plamann L. A Myxococcus xanthus cell density-sensing system required for multicellular development. FEMS Microbiol Lett. 1996 Jun 1;139(2-3):89–95. doi: 10.1111/j.1574-6968.1996.tb08185.x. [DOI] [PubMed] [Google Scholar]
  10. Keseler I. M., Kaiser D. An early A-signal-dependent gene in Myxococcus xanthus has a sigma 54-like promoter. J Bacteriol. 1995 Aug;177(16):4638–4644. doi: 10.1128/jb.177.16.4638-4644.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kroos L., Kuspa A., Kaiser D. A global analysis of developmentally regulated genes in Myxococcus xanthus. Dev Biol. 1986 Sep;117(1):252–266. doi: 10.1016/0012-1606(86)90368-4. [DOI] [PubMed] [Google Scholar]
  12. Kuspa A., Kaiser D. Genes required for developmental signalling in Myxococcus xanthus: three asg loci. J Bacteriol. 1989 May;171(5):2762–2772. doi: 10.1128/jb.171.5.2762-2772.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kuspa A., Kroos L., Kaiser D. Intercellular signaling is required for developmental gene expression in Myxococcus xanthus. Dev Biol. 1986 Sep;117(1):267–276. doi: 10.1016/0012-1606(86)90369-6. [DOI] [PubMed] [Google Scholar]
  14. Kuspa A., Plamann L., Kaiser D. A-signalling and the cell density requirement for Myxococcus xanthus development. J Bacteriol. 1992 Nov;174(22):7360–7369. doi: 10.1128/jb.174.22.7360-7369.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kuspa A., Plamann L., Kaiser D. Identification of heat-stable A-factor from Myxococcus xanthus. J Bacteriol. 1992 May;174(10):3319–3326. doi: 10.1128/jb.174.10.3319-3326.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kustu S., Santero E., Keener J., Popham D., Weiss D. Expression of sigma 54 (ntrA)-dependent genes is probably united by a common mechanism. Microbiol Rev. 1989 Sep;53(3):367–376. doi: 10.1128/mr.53.3.367-376.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. LaRossa R., Kuner J., Hagen D., Manoil C., Kaiser D. Developmental cell interactions of Myxococcus xanthus: analysis of mutants. J Bacteriol. 1983 Mar;153(3):1394–1404. doi: 10.1128/jb.153.3.1394-1404.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Plamann L., Davis J. M., Cantwell B., Mayor J. Evidence that asgB encodes a DNA-binding protein essential for growth and development of Myxococcus xanthus. J Bacteriol. 1994 Apr;176(7):2013–2020. doi: 10.1128/jb.176.7.2013-2020.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Plamann L., Kuspa A., Kaiser D. Proteins that rescue A-signal-defective mutants of Myxococcus xanthus. J Bacteriol. 1992 May;174(10):3311–3318. doi: 10.1128/jb.174.10.3311-3318.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Plamann L., Li Y., Cantwell B., Mayor J. The Myxococcus xanthus asgA gene encodes a novel signal transduction protein required for multicellular development. J Bacteriol. 1995 Apr;177(8):2014–2020. doi: 10.1128/jb.177.8.2014-2020.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Singer M., Kaiser D. Ectopic production of guanosine penta- and tetraphosphate can initiate early developmental gene expression in Myxococcus xanthus. Genes Dev. 1995 Jul 1;9(13):1633–1644. doi: 10.1101/gad.9.13.1633. [DOI] [PubMed] [Google Scholar]

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