Abstract
Of 74 patients seen within 30 minutes of the onset of acute myocardial infarction 68 (92%) had signs of autonomic imbalance. Excessive vagal activity was evident in 41 (55%) and there was sympathetic overactivity in 27 (36%). The high incidence of sudden death in the acute phase of a coronary attack probably results from the electrical imbalance caused by autonomic disturbance. This disturbance must therefore be taken into account in any prophylactic regimen against the lethal early ventricular dysrhythmias.
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- Adgey A. A., Allen J. D., Geddes J. S., James R. G., Webb S. W., Zaidi S. A., Pantridge J. F. Acute phase of myocardial infarction. Lancet. 1971 Sep 4;2(7723):501–504. doi: 10.1016/s0140-6736(71)90434-x. [DOI] [PubMed] [Google Scholar]
- Adgey A. A., Geddes J. S., Mulholland H. C., Keegan D. A., Pantridge J. F. Incidence, significance, and management of early bradyarrhythmia complicating acute myocardial infarction. Lancet. 1968 Nov 23;2(7578):1097–1101. doi: 10.1016/s0140-6736(68)91577-8. [DOI] [PubMed] [Google Scholar]
- Ceremuzyński L., Staszewska-Barczak J., Herbaczynska-Cedro K. Cardiac rhythm disturbances and the release of catecholamines after acute coronary occlusion in dogs. Cardiovasc Res. 1969 Apr;3(2):190–197. doi: 10.1093/cvr/3.2.190. [DOI] [PubMed] [Google Scholar]
- Friedberg C. K. Symposium: myocardial infarction 1972. 1. Introduction. Circulation. 1972 Jan;45(1):179–188. doi: 10.1161/01.cir.45.1.179. [DOI] [PubMed] [Google Scholar]
- HAN J., GARCIADEJALON P., MOE G. K. ADRENERGIC EFFECTS ON VENTRICULAR VULNERABILITY. Circ Res. 1964 Jun;14:516–524. doi: 10.1161/01.res.14.6.516. [DOI] [PubMed] [Google Scholar]
- HAN J., MOE G. K. NONUNIFORM RECOVERY OF EXCITABILITY IN VENTRICULAR MUSCLE. Circ Res. 1964 Jan;14:44–60. doi: 10.1161/01.res.14.1.44. [DOI] [PubMed] [Google Scholar]
- Han J., Millet D., Chizzonitti B., Moe G. K. Temporal dispersion of recovery of excitability in atrium and ventricle as a function of heart rate. Am Heart J. 1966 Apr;71(4):481–487. doi: 10.1016/0002-8703(66)90213-4. [DOI] [PubMed] [Google Scholar]
- Levine H. J. Pre-hospital management of acute myocardial infarction. Am J Cardiol. 1969 Dec;24(6):826–830. doi: 10.1016/0002-9149(69)90471-8. [DOI] [PubMed] [Google Scholar]
- Levy M. N., Zieske H. Autonomic control of cardiac pacemaker activity and atrioventricular transmission. J Appl Physiol. 1969 Oct;27(4):465–470. doi: 10.1152/jappl.1969.27.4.465. [DOI] [PubMed] [Google Scholar]
- Lown B., Vassaux C. Lidocaine in acute myocardial infarction. Am Heart J. 1968 Oct;76(4):586–587. doi: 10.1016/0002-8703(68)90148-8. [DOI] [PubMed] [Google Scholar]
- Lown B., Wolf M. Approaches to sudden death from coronary heart disease. Circulation. 1971 Jul;44(1):130–142. doi: 10.1161/01.cir.44.1.130. [DOI] [PubMed] [Google Scholar]
- Malliani A., Schwartz P. J., Zanchetti A. A sympathetic reflex elicited by experimental coronary occlusion. Am J Physiol. 1969 Sep;217(3):703–709. doi: 10.1152/ajplegacy.1969.217.3.703. [DOI] [PubMed] [Google Scholar]
- Maroko P. R., Kjekshus J. K., Sobel B. E., Watanabe T., Covell J. W., Ross J., Jr, Braunwald E. Factors influencing infarct size following experimental coronary artery occlusions. Circulation. 1971 Jan;43(1):67–82. doi: 10.1161/01.cir.43.1.67. [DOI] [PubMed] [Google Scholar]
- McNeilly R. H., Pemberton J. Duration of last attack in 998 fatal cases of coronary artery disease and its relation to possible cardiac resuscitation. Br Med J. 1968 Jul 20;3(5611):139–142. doi: 10.1136/bmj.3.5611.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pantridge J. F., Adgey A. A. Pre-hospital coronary care. The mobile coronary care unit. Am J Cardiol. 1969 Nov;24(5):666–673. doi: 10.1016/0002-9149(69)90454-8. [DOI] [PubMed] [Google Scholar]
- Pantridge J. F., Geddes J. S. A mobile intensive-care unit in the management of myocardial infarction. Lancet. 1967 Aug 5;2(7510):271–273. doi: 10.1016/s0140-6736(67)90110-9. [DOI] [PubMed] [Google Scholar]
- Pantridge J. F., Geddes J. S. Cardiac arrest after myocardial infarction. Lancet. 1966 Apr 9;1(7441):807–808. doi: 10.1016/s0140-6736(66)91883-6. [DOI] [PubMed] [Google Scholar]
- Peterson D. F., Brown A. M. Pressor reflexes produced by stimulation of afferent fibers in the cardiac sympathetic nerves of the cat. Circ Res. 1971 Jun;28(6):605–610. doi: 10.1161/01.res.28.6.605. [DOI] [PubMed] [Google Scholar]
- Samaan A. The antagonistic cardiac nerves and heart rate. J Physiol. 1935 Feb 9;83(3):332–340. doi: 10.1113/jphysiol.1935.sp003232. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yu P. N. Prehospital care of acute myocardial infarction. Circulation. 1972 Jan;45(1):189–204. doi: 10.1161/01.cir.45.1.189. [DOI] [PubMed] [Google Scholar]