Abstract
Immunoreactive human serum prolactin of pituitary origin has been measured by a radioimmunoassay developed for ovine prolactin. Blood samples were collected at four-hour intervals during a 24-hour period from 12 non-pregnant women, three pregnant women, and seven adult men. A circadian periodicity was found in serum prolactin concentration, with peak values during the night, between 1 a.m. and 5 a.m. for the non-pregnant women, and at 5 a.m. for the adult men. Mean serum levels of prolactin were 1·5 times higher in non-pregnant women than in men. In women investigated during the last month of their pregnancy the mean serum prolactin levels were 2·3 times higher than in the non-pregnant women, but there was no circadian periodicity.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bowers C. Y., Friesen H. G., Hwang P., Guyda H. J., Folkers K. Prolactin and thyrotropin release in man by synthetic pyroglutamyl-histidyl-prolinamide. Biochem Biophys Res Commun. 1971 Nov;45(4):1033–1041. doi: 10.1016/0006-291x(71)90441-4. [DOI] [PubMed] [Google Scholar]
- CLARK R. H., BAKER B. L. CIRCADIAN PERIODICITY IN THE CONCENTRATION OF PROLACTIN IN THE RAT HYPOPHYSIS. Science. 1964 Jan 24;143(3604):375–376. doi: 10.1126/science.143.3604.375. [DOI] [PubMed] [Google Scholar]
- Davis S. L., Reichert L. E., Jr, Niswender G. D. Serum levels of prolactin in sheep as measured by radioimmunoassay. Biol Reprod. 1971 Apr;4(2):145–153. doi: 10.1093/biolreprod/4.2.145. [DOI] [PubMed] [Google Scholar]
- Dunn J. D., Arimura A., Scheving L. E. Effect of stress on circadian periodicity in serum LH and prolactin concentration. Endocrinology. 1972 Jan;90(1):29–33. doi: 10.1210/endo-90-1-29. [DOI] [PubMed] [Google Scholar]
- GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
- L'Hermite M., Copinschi G., Golstein J., Vanhaelst L., Leclercq R., Bruno O. D. Prolactin release after injection of thyrotrophin-releasing hormone in man. Lancet. 1972 Apr 8;1(7754):763–765. doi: 10.1016/s0140-6736(72)90519-3. [DOI] [PubMed] [Google Scholar]
- L'Hermite M., Midgley A. R., Jr Radioimmunoassay of human follicle-stimulating hormone with antisera to the ovine hormone. J Clin Endocrinol Metab. 1971 Jul;33(1):68–76. doi: 10.1210/jcem-33-1-68. [DOI] [PubMed] [Google Scholar]
- Rodbard D., Rayford P. L., Cooper J. A., Ross G. T. Statistical quality control of radioimmunoassays. J Clin Endocrinol Metab. 1968 Oct;28(10):1412–1418. doi: 10.1210/jcem-28-10-1412. [DOI] [PubMed] [Google Scholar]