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. 1972 Sep 2;3(5826):559–561. doi: 10.1136/bmj.3.5826.559

Screening for Malignant Hyperpyrexia

F Richard Ellis, Niall P Keaney, D G F Harriman, D W Sumner, K Kyei-Mensah, J H Tyrrell, J B Hargreaves, R K Parikh, P L Mulrooney
PMCID: PMC1785894  PMID: 5069639

Abstract

The methods used to screen patients for malignant hyperpyrexia at present are not sufficiently accurate. This paper reports more specific methods of detecting patients liable to develop malignant hyperpyrexia. A motor-point muscle biopsy is performed for histopathological examination and to detect muscle contracture in vitro after exposure to halothane and suxamethonium.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Britt B. A., Kalow W. Malignant hyperthermia: a statistical review. Can Anaesth Soc J. 1970 Jul;17(4):293–315. doi: 10.1007/BF03004694. [DOI] [PubMed] [Google Scholar]
  2. DENBOROUGH M. A., FORSTER J. F., LOVELL R. R., MAPLESTONE P. A., VILLIERS J. D. Anaesthetic deaths in a family. Br J Anaesth. 1962 Jun;34:395–396. doi: 10.1093/bja/34.6.395. [DOI] [PubMed] [Google Scholar]
  3. Ellis F. R., Harriman D. G., Keaney N. P., Kyei-Mensah K., Tyrrell J. H. Halothane-induced muscle contracture as a cause of hyperpyrexia. Br J Anaesth. 1971 Jul;43(7):721–722. [PubMed] [Google Scholar]
  4. Isaacs H., Barlow M. B. Malignant hyperpyrexia during anaesthesia: possible association with subclinical myopathy. Br Med J. 1970 Jan 31;1(5691):275–277. doi: 10.1136/bmj.1.5691.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Keaney N. P., Ellis F. R. Malignant hyperpyrexia. Br Med J. 1971 Oct 2;4(5778):49–49. doi: 10.1136/bmj.4.5778.49-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. King J. O., Denborough M. A., Zapf P. W. Inheritance of malignant hyperpyrexia. Lancet. 1972 Feb 12;1(7746):365–370. doi: 10.1016/s0140-6736(72)92854-1. [DOI] [PubMed] [Google Scholar]
  7. Larard D. G., Rice C. P., Robinson R., Spencer R. W., Westhead R. A. Malignant hyperthermia: a study of an affected family. Br J Anaesth. 1972 Jan;44(1):93–96. doi: 10.1093/bja/44.1.93. [DOI] [PubMed] [Google Scholar]
  8. Steers A. J., Tallack J. A., Thompson D. E. Fulminating hyperpyrexia during anaesthesia in a member of a myopathic family. Br Med J. 1970 May 9;2(5705):341–343. doi: 10.1136/bmj.2.5705.341. [DOI] [PMC free article] [PubMed] [Google Scholar]

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