Skip to main content
British Medical Journal logoLink to British Medical Journal
. 1972 Sep 16;3(5828):661–664. doi: 10.1136/bmj.3.5828.661

Double-blind Trial of Carbenoxolone Sodium Capsules in Duodenal Ulcer Therapy, Based on Endoscopic Diagnosis and Follow-up

P Brown, P R Salmon, Thien-Htut, A E Read
PMCID: PMC1786048  PMID: 4568356

Abstract

A high-dose double-blind trial of carbenoxolone sodium capsules (Duogastrone) in the treatment of duodenal ulceration was combined with endoscopic diagnosis and follow-up. Thirty-one ambulant patients with an endoscopically visible duodenal ulcer were allocated at random to a 12-week course of treatment with either carbenoxolone sodium 300 mg daily or a placebo. Symptomatic and endoscopic follow-up was performed at 2-4 weeks, 6-8 weeks, and 12-16 weeks. Carbenoxolone was shown to increase the rate of healing of duodenal ulcers in the early stages of treatment, but by 12 weeks there was no difference between the two groups. There was no significant difference in symptomatic improvement between the two groups at any stage of treatment. Side effects, especially hypokalaemia, were prominent in the patients treated with carbenoxolone. There was a poor relation between endoscopic and symptomatic improvement in patients on either form of treatment.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amure B. O. Clinical study of Duogastrone in the treatment of duodenal ulcers. Gut. 1970 Feb;11(2):171–175. doi: 10.1136/gut.11.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BERNSTEIN L. M., BAKER L. A. A clinical test for esophagitis. Gastroenterology. 1958 May;34(5):760–781. [PubMed] [Google Scholar]
  3. Brown P., Salmon P. R., Read A. E. Premedication for gastrointestinal endoscopy. Lancet. 1972 Jan 29;1(7744):270–270. doi: 10.1016/s0140-6736(72)90669-1. [DOI] [PubMed] [Google Scholar]
  4. Cliff J. M., Milton-Thompson G. J. A double-blind trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer. Gut. 1970 Feb;11(2):167–170. doi: 10.1136/gut.11.2.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Craig O., Hunt T., Kimerling J. J., Parke D. V. Carbenoxolone in the treatment of duodenal ulcer. Practitioner. 1967 Jul;199(189):109–111. [PubMed] [Google Scholar]
  6. DOLL R., HILL I. D., HUTTON C. F. TREATMENT OF GASTRIC ULCER WITH CARBENOXOLONE SODIUM AND OESTROGENS. Gut. 1965 Feb;6:19–24. doi: 10.1136/gut.6.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Horwich L., Galloway R. Treatment of gastric ulceration with carbenoxolone sodium: clinical and radiological evaluation. Br Med J. 1965 Nov 27;2(5473):1274–1277. doi: 10.1136/bmj.2.5473.1274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mitchell A. B. Duogastrone-induced hypokalaemic nephropathy and myopathy with myoglobinuria. Postgrad Med J. 1971 Dec;47(554):807–813. doi: 10.1136/pgmj.47.554.807. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Montgomery R. D., Lawrence I. H., Manton D. J., Mendl K., Rowe P. A controlled trial of carbenoxolone sodium capsules in the treatment of duodenal ulcer. Gut. 1968 Dec;9(6):704–706. doi: 10.1136/gut.9.6.704. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Polland W. S., Bloomfield A. L. EXPERIMENTAL REFERRED PAIN FROM THE GASTRO-INTESTINAL TRACT. PART I. THE ESOPHAGUS. J Clin Invest. 1931 Aug;10(3):435–452. doi: 10.1172/JCI100363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. RUFFIN J. M., BAYLIN G. J., LEGERTON C. W., Jr, TEXTER E. C. Mechanism of pain in peptic ulcer. Gastroenterology. 1953 Feb;23(2):252–269. [PubMed] [Google Scholar]
  12. SMITH A. W. The pain of peptic ulceration. Q J Med. 1955 Oct;24(96):393–407. [PubMed] [Google Scholar]
  13. Salmon P. R., Brown P., Htut T., Read A. E. Endoscopic examination of the duodenal bulb: clinical evaluation of forward- and side-viewing fibreoptic systems in 200 cases. Gut. 1972 Mar;13(3):170–175. doi: 10.1136/gut.13.3.170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Turpie A. G., Thomson T. J. Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects. Gut. 1965 Dec;6(6):591–594. doi: 10.1136/gut.6.6.591. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES