Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1972 Oct 7;4(5831):15–16. doi: 10.1136/bmj.4.5831.15

Origin of Endothelium in Human Renal Allografts

R A Sinclair
PMCID: PMC1786148  PMID: 4562278

Abstract

Sex chromatin counts performed on the endothelial cells of 40 human kidneys transplanted to recipients of the opposite sex showed that the donor endothelium had persisted except in three poorly functioning and severely damaged grafts. In these a high proportion of the endothelial cells in peritubular capillaries and veins were derived from the host. Endothelial repopulation of organ allografts probably occurs only after severe tissue injury, and it cannot explain the phenomenon of graft adaptation. Repopulated endothelium may be derived from circulating cells.

Full text

PDF
15

Images in this article

15p15-a
on p.15

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALEXANDRE G. P., MURRAY J. E., DAMMIN G. J., NOLAN B. IMMUNOSUPPRESSIVE DRUG THERAPY IN CANINE RENAL AND SKIN HOMOGRAFTS. Transplantation. 1963 Oct;1:432–461. doi: 10.1097/00007890-196301040-00002. [DOI] [PubMed] [Google Scholar]
  2. Bieber C. P., Stinson E. B., Shumway N. E., Payne R., Kosek J. Cardiac transplantation in man. VII. Cardiac allograft pathology. Circulation. 1970 May;41(5):753–772. doi: 10.1161/01.cir.41.5.753. [DOI] [PubMed] [Google Scholar]
  3. Bohle A., Fischbach H. Weitere Befunde zur sog. Transplantatadaptation menschlicher Nieren. Virchows Arch A Pathol Pathol Anat. 1970;349(2):170–178. [PubMed] [Google Scholar]
  4. Kosek J. C., Chartrand C., Hurley E. J., Lower R. R. Arteries in canine cardiac homografts. Ultrastructure during acute rejection. Lab Invest. 1969 Oct;21(4):328–335. [PubMed] [Google Scholar]
  5. MURRAY J. E., SHEIL A. G., MOSELEY R., KNIGHT P., MCGAVIC J. D., DAMMIN G. J. ANALYSIS OF MECHANISM OF IMMUNOSUPPRESSIVE DRUGS IN RENAL HOMOTRANSPLANTATION. Ann Surg. 1964 Sep;160:449–473. doi: 10.1097/00000658-196409000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. O'NEAL R. M., JORDAN G. L., Jr, RABIN E. R., DEBAKEY M. E., HALPERT B. CELLS GROWN ON ISOLATED INTRAVASCULAR DACRON HUB; AN ELECTRON MICROSCOPIC STUDY. Exp Mol Pathol. 1964 Oct;90:403–412. doi: 10.1016/0014-4800(64)90022-x. [DOI] [PubMed] [Google Scholar]
  7. STUMP M. M., JORDAN G. L., Jr, DEBAKEY M. E., HALPERT B. ENDOTHELIUM GROWN FROM CIRCULATING BLOOD ON ISOLATED INTRAVASCULAR DACRON HUB. Am J Pathol. 1963 Sep;43:361–367. [PMC free article] [PubMed] [Google Scholar]
  8. Williams G. M., Alvarez C. A. Host repopulation of the endothelium in allografts of kidneys and aorta. Surg Forum. 1969;20:293–294. [PubMed] [Google Scholar]
  9. Williams G. M., Krajewski C. A., Dagher F. J., ter Haar A. M., Roth J. A., Santos G. W. Host repopulation of endothelium. Transplant Proc. 1971 Mar;3(1):869–872. [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES