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. 1972 Oct 7;4(5831):22–23. doi: 10.1136/bmj.4.5831.22

Gastric Acid Secretion in Chronic Renal Failure

P S Ventkateswaran, A Jeffers, A G Hocken
PMCID: PMC1786162  PMID: 5078407

Abstract

Contrary to the small amount of published evidence, but in accordance with clinical impression, we have found an increased incidence of peptic ulceration in people with chronic renal failure. Hyperacidic secretion in response to a standard pentagastrin test occurs in patients established on long-term dialysis treatment. The traditional liability of azotaemic patients to peptic ulceration seems not to be decreased by adequate long-term dialysis and indeed may be worsened.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARON J. H. Studies of basal and peak acid output with an augmented histamine test. Gut. 1963 Jun;4:136–144. doi: 10.1136/gut.4.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barreras R. F., Donaldson R. M., Jr Role of calcium in gastric hypersecretion, parathyroid adenoma and peptic ulcer. N Engl J Med. 1967 May 18;276(20):1122–1124. doi: 10.1056/NEJM196705182762005. [DOI] [PubMed] [Google Scholar]
  3. FILLASTRE J. P., BLAISE P., ARDAILLOU R., RICHET G. S'ECR'ETION GASTRIQUE DES UR'EMIES CHRONIQUES. Rev Fr Etud Clin Biol. 1965 Feb;10:180–190. [PubMed] [Google Scholar]
  4. Goldstein H., Murphy D., Sokol A., Rubini M. E. Gastric acid secretion in patients undergoing chronic dialysis. Arch Intern Med. 1967 Dec;120(6):645–653. [PubMed] [Google Scholar]
  5. Gordon E. M., Johnson A. G., Williams G. Gastric assessment of prospective renal-transplant patients. Lancet. 1972 Jan 29;1(7744):226–229. doi: 10.1016/s0140-6736(72)90623-x. [DOI] [PubMed] [Google Scholar]
  6. Hadjiyannakis E. J., Smellie W. A., Evans D. B., Calne R. Y. Gastrointestinal complications after renal transplantation. Lancet. 1971 Oct 9;2(7728):781–785. doi: 10.1016/s0140-6736(71)92739-5. [DOI] [PubMed] [Google Scholar]
  7. Johnston D., Jepson K. Use of pentagastrin in a test of gastric acid secretion. Lancet. 1967 Sep 16;2(7516):585–588. doi: 10.1016/s0140-6736(67)90739-8. [DOI] [PubMed] [Google Scholar]
  8. Kiil F., Enger E. Compensatory changes in renal electrolyte excretion to removal of gastric HC1 in normal and uremic man. Scand J Clin Lab Invest. 1968 Dec;22(4):277–287. doi: 10.3109/00365516809167064. [DOI] [PubMed] [Google Scholar]
  9. Korman M. G., Laver M. C., Hansky J. Hypergastrinaemia in chronic renal failure. Br Med J. 1972 Jan 22;1(5794):209–210. doi: 10.1136/bmj.1.5794.209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Moore T. C., Hume D. M. The period and nature of hazard in clinical renal transplantation. I. The hazard to patient survival. Ann Surg. 1969 Jul;170(1):1–11. doi: 10.1097/00000658-196907000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Schupak E., Ferayorni J. Gastric secretory studies in patients undergoing chronic hemodialysis. Am J Dig Dis. 1968 Aug;13(8):747–752. doi: 10.1007/BF02233000. [DOI] [PubMed] [Google Scholar]
  12. Wiener S. N., Vertes V., Shapiro H. The upper gastrointestinal tract in patients ungergoing chronic dialysis. Radiology. 1969 Jan;92(1):110–114. doi: 10.1148/92.1.110. [DOI] [PubMed] [Google Scholar]

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