Abstract
The clinical value has been assessed of circulating placental lactogen levels as a pointer to the outcome in a patient with vaginal bleeding in early pregnancy. By using a semiautomated radioimmunoassay the normal range of values for the first and second trimesters has been established. In patients admitted with vaginal bleeding after the eighth week of gestation estimation of plasma human placental lactogen showed that patients with low levels were those in whom the abortion was completed during the first admission. Women whose pregnancies continued normally or who aborted after their first discharge from hospital had normal levels. In a small group sampled before the onset of bleeding but who later aborted the mean levels were lower than normal. This simple and inexpensive test can indicate those women in whom abortion is inevitable and could be used to reduce substantially the length of hospital stay in this common complication of early pregnancy.
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Selected References
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- Genazzani A. R., Aubert M. L., Casoli M., Fioretti P., Felber J. P. Use of human-placental-lactogen radioimmunoassay to predict outcome in cases of threatened abortion. Lancet. 1969 Dec 27;2(7635):1385–1387. doi: 10.1016/s0140-6736(69)90932-5. [DOI] [PubMed] [Google Scholar]
- Genazzani A. R., Cocola F., Casoli M., Mello G., Scarselli G., Neri P., Fioretti P. Human chorionic somatomammotrophin radioimmunoassay in evaluation of placental function. J Obstet Gynaecol Br Commonw. 1971 Jul;78(7):577–589. doi: 10.1111/j.1471-0528.1971.tb00320.x. [DOI] [PubMed] [Google Scholar]
- Haour F., Cohen M., Bertrand J. Radioimmunoassay of human chorionic somatomammatropin (HCS) plasma levels in normal and abnormal pregnancies. Rev Eur Etud Clin Biol. 1971 Feb;16(2):124–130. [PubMed] [Google Scholar]
- Letchworth A. T., Boardman R. J., Bristow C., Landon J., Chard T. A rapid semi-automated method for the measurement of human chorionic somatomammotrophin. The normal range in the third trimester and its relation to fetal weight. J Obstet Gynaecol Br Commonw. 1971 Jun;78(6):542–548. doi: 10.1111/j.1471-0528.1971.tb00313.x. [DOI] [PubMed] [Google Scholar]
- Saxena B. N., Emerson K., Jr, Selenkow H. A. Serum placental lactogen (HPL) levels as an index of placental function. N Engl J Med. 1969 Jul 31;281(5):225–231. doi: 10.1056/NEJM196907312810501. [DOI] [PubMed] [Google Scholar]
- Singer W., Desjardins P., Friesen H. G. Human placental lactogen. An index of placental function. Obstet Gynecol. 1970 Aug;36(2):222–232. [PubMed] [Google Scholar]
- Spona J., Janisch H. Serum placental lactogen (HPL) as index of placental function. Acta Endocrinol (Copenh) 1971 Oct;68(2):401–412. doi: 10.1530/acta.0.0680401. [DOI] [PubMed] [Google Scholar]