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. 1972 Oct 21;4(5833):142–144. doi: 10.1136/bmj.4.5833.142

Liver Preservation by Single Passage Hypothermic “Squirt” Perfusion

R Y Calne, D C Dunn, B M Herbertson, E M Gordon, H Bitter-Suermann, A J Robson, A S Macdonald, D R Davis, D P Smith, F H Reitter, L M Webster
PMCID: PMC1786401  PMID: 4562283

Abstract

A single passage, hypothermic, intermittent squirt perfusion of the pig's liver is described which has allowed preservation of porcine livers for up to 17 hours. After preservation, orthotopically allografted livers can maintain recipient animals in good health. If this technique can be applied to clinical liver transplantation it should be possible to move livers from one hospital to another in the same way that kidneys are transported. This should increase the availability of donor livers for transplantation and avoid the serious disadvantages of moving the sick recipient just before the operation to the hospital where the donor has died.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Belzer F. O., Ashby B. S., Dunphy J. E. 24-hour and 72-hour preservation of canine kidneys. Lancet. 1967 Sep 9;2(7515):536–538. doi: 10.1016/s0140-6736(67)90498-9. [DOI] [PubMed] [Google Scholar]
  2. Calne R. Y., Dunn D. C., Gajo-Reyero R., Hadjiyannakis E. J., Robson A. J. Trickle perfusion for organ preservation. Nature. 1972 Jan 21;235(5334):171–173. doi: 10.1038/235171a0. [DOI] [PubMed] [Google Scholar]
  3. Calne R. Y., Williams R. Liver transplantation in man. I. Observations on technique and organization in five cases. Br Med J. 1968 Nov 30;4(5630):535–540. doi: 10.1136/bmj.4.5630.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Calne R. Y., Yoffa D. E., White H. J., Maginn R. R. A technique of orthotopic liver translantation in the pig. Br J Surg. 1968 Mar;55(3):203–206. doi: 10.1002/bjs.1800550310. [DOI] [PubMed] [Google Scholar]
  5. Collins G. M., Bravo-Shugarman M., Terasaki P. I. Kidney preservation for transportation. Initial perfusion and 30 hours' ice storage. Lancet. 1969 Dec 6;2(7632):1219–1222. doi: 10.1016/s0140-6736(69)90753-3. [DOI] [PubMed] [Google Scholar]
  6. Hadjiyannakis E. J., Calne R. Y., Marshall V. C., Davis D. R. Successful preservation of pig's liver for 5-8 hours by simple ice storage. Br J Surg. 1971 Nov;58(11):835–836. doi: 10.1002/bjs.1800581109. [DOI] [PubMed] [Google Scholar]
  7. Herrmann T. J., Turcotte J. G. Preservation of canine kidneys by hypothermia and low flow perfusion with bloodless perfusate. Arch Surg. 1969 Jan;98(1):121–127. doi: 10.1001/archsurg.1969.01340070139033. [DOI] [PubMed] [Google Scholar]
  8. Turner M. D., Alican F. Successful 20-hour storage of the canine liver by continuous hypothermic perfusion. Cryobiology. 1970 Jan-Feb;6(4):293–301. doi: 10.1016/s0011-2240(70)80083-9. [DOI] [PubMed] [Google Scholar]

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