Skip to main content
British Medical Journal logoLink to British Medical Journal
. 1972 Oct 21;4(5833):139–141. doi: 10.1136/bmj.4.5833.139

Kidney Preservation by Surface Cooling: Analysis of 130 Transplants

B Hulme, M E Snell, J R Kenyon, K Owen, W S Peart
PMCID: PMC1786433  PMID: 4562282

Abstract

An analysis of 130 consecutive cadaveric renal transplants has shown the effectiveness of simple surface cooling of organs before transplantation. The primary graft failure rate was 10%, and kidneys could be stored for periods of up to 12 hours including warm ischaemia times of 150 minutes. Forty-eight patients received haemodialysis before transplantation and 78 patients received peritoneal dialysis. There were significant differences in the incidence of tubular necrosis in the two groups: these may have been linked to the differences in fluid and osmotic load presented to the transplants.

Full text

PDF
139

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ackermann J. R., Hopkinson W. I., Gradman W. S. A mobile system for cadaver kidney preservation. Transplant Proc. 1969 Mar;1(1):153–159. [PubMed] [Google Scholar]
  2. Ackermann J. R., Snell M. E. Cadaveric renal transplantation: a technique for donor kidney removal. Br J Urol. 1968 Oct;40(5):515–521. doi: 10.1111/j.1464-410x.1968.tb11842.x. [DOI] [PubMed] [Google Scholar]
  3. Belzer F. O., Ashby B. S., Huang J. S., Dunphy J. E. Etiology of rising perfusion pressure in isolated organ perfusion. Ann Surg. 1968 Sep;168(3):382–391. doi: 10.1097/00000658-196809000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Belzer F. O., Kountz S. L. Preservation and transplantation of human cadaver kidneys: a two-year experience. Ann Surg. 1970 Sep;172(3):394–404. doi: 10.1097/00000658-197009000-00009. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brunius U., Bergentz S. E., Ekman H., Gelin L. E., Westberg G. The cadaveric kidney in clinical transplantation. Scand J Urol Nephrol. 1968;2(1):15–23. doi: 10.3109/00365596809133557. [DOI] [PubMed] [Google Scholar]
  6. Cohen S. L., Percival A. Prolonged peritoneal dialysis in patients awaiting renal transplantation. Br Med J. 1968 Feb 17;1(5589):409–413. doi: 10.1136/bmj.1.5589.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Collins G. M., Bravo-Shugarman M., Terasaki P. I. Kidney preservation for transportation. Initial perfusion and 30 hours' ice storage. Lancet. 1969 Dec 6;2(7632):1219–1222. doi: 10.1016/s0140-6736(69)90753-3. [DOI] [PubMed] [Google Scholar]
  8. Festenstein H., Oliver R. T., Sachs J. A., Burke J. M., Adams E., Divver W., Hyams A., Pegrum G. D., Balfour I. C., Moorhead J. F. Multicentre collaboration in 162 tissue-typed renal transplants. The London and Regional Transplant Group, March, 1969, to December, 1970. Lancet. 1971 Jul 31;2(7718):225–228. doi: 10.1016/s0140-6736(71)92569-4. [DOI] [PubMed] [Google Scholar]
  9. Fisher E. R., Copeland C., Fisher B. Correlation of ultrastructure and function following hypothermic preservation of canine kidneys. Lab Invest. 1967 Jul;17(1):99–119. [PubMed] [Google Scholar]
  10. Hartley L. C., Collins G. M., Clunie G. J. Kidney preservation for transportation. Function of 29 human-cadaver kidneys preserved with an intracellular perfusate. N Engl J Med. 1971 Nov 4;285(19):1049–1052. doi: 10.1056/NEJM197111042851903. [DOI] [PubMed] [Google Scholar]
  11. Liu W. P., Humphries A. L., Jr, Russell R., Stoddard L. D., Moretz W. H. 48-hour storage of canine kidneys after brief perfusion with Collins' solution. Ann Surg. 1971 May;173(5):748–757. doi: 10.1097/00000658-197105000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mowbray J. F., Cohen S. L., Doak P. B., Kenyon J. R., Owen K., Percival A., Porter K. A., Peart W. S. Human cadaveric renal transplantation. Report of twenty cases. Br Med J. 1965 Dec 11;2(5475):1387–1394. doi: 10.1136/bmj.2.5475.1387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Tanaka N., Stevens L. E., Terasaki P. I. Storage and transport of 83 human kidneys by simple hypothermia. Transplantation. 1971 Nov;12(5):348–352. doi: 10.1097/00007890-197111000-00002. [DOI] [PubMed] [Google Scholar]
  14. White H. J., Evans D. B., Calne R. Y. Function of cadaver renal homografts in relation to age of donor, cause of death, and ischemia time. Br Med J. 1968 Dec 21;4(5633):739–740. doi: 10.1136/bmj.4.5633.739. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Williams G. M., White H. J., Hume D. M. Factors influencing the long term functional success rate of human renal allografts. Transplantation. 1967 Jul;5(4 Suppl):837–843. doi: 10.1097/00007890-196707001-00009. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES