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. 1972 Oct 28;4(5834):196–198. doi: 10.1136/bmj.4.5834.196

High Dosage Metolazone in Chronic Renal Failure

H J Dargie, Marjorie E M Allison, A C Kennedy, Mary J B Gray
PMCID: PMC1786502  PMID: 5082545

Abstract

Metolazone is a modified quinazolinesulphonamide and in a dose of between 4 and 7·5 mg is an effective diuretic in man with normal renal function. Fourteen patients with non-oedematous stable chronic renal failure (creatinine clearance ranging from 1·2 to 12 ml/min) were given metolazone in doses ranging from 20-150 mg. A noticeable increase in urine flow and sodium excretion occurred, free water clearance increased, and there was a small but significant increase in potassium excretion. No side effects were noted.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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