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. 1972 Nov 25;4(5838):454–458. doi: 10.1136/bmj.4.5838.454

Haemostatic Changes during Dialysis Associated with Thrombus Formation on Dialysis Membranes

R M Lindsay, C R M Prentice, J F Davidson, J A Burton, G P McNicol
PMCID: PMC1786749  PMID: 4653875

Abstract

Platelet counts, coagulation factors, and the fibrinolytic system were studied in seven regular dialysis patients during the course of haemodialysis by parallel flow (Gambro-Alwall) and coil (Travenol Ultra-Flo 100) dialysers. Significant falls in the patients' platelet counts and rises in their factor V levels were found with both dialysis systems. The changes were more pronounced over the course of a Gambro-Alwall dialysis, when significant falls in the partial thromboplastin clotting time and in the plasminogen levels were also noted. These haemostatic changes were associated with the retention of platelets on the dialysis membranes and, in the case of the Gambro-Alwall dialyser, with the formation of platelet-fibrin thrombus. This thrombus formation may take place in spite of efficient heparin anticoagulation and may cause excessive blood loss to the regular dialysis patient.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRECKENRIDGE R. T., RATNOFF C. D. Studies on the nature of the circulating anticoagulant directed against antihemophilic factor: with notes on an assay for anthemophilic factor. Blood. 1962 Aug;20:137–149. [PubMed] [Google Scholar]
  2. GODAL H. C. The antiheparin effect of platelets. Scand J Clin Lab Invest. 1962;14:223–229. [PubMed] [Google Scholar]
  3. HARDISTY R. M., HUTTON R. A. THE KAOLIN CLOTTING TIME OF PLATELET-RICH PLASMA: A TEST OF PLATELET FACTOR-3 AVAILABILITY. Br J Haematol. 1965 May;11:258–268. doi: 10.1111/j.1365-2141.1965.tb06586.x. [DOI] [PubMed] [Google Scholar]
  4. Hesse V. E., Mink I. B., Murphy G. P., Moore R. H., Ambrus J. L. Hemodialysis and hemostatic function. N Y State J Med. 1970 Jul 15;70(14):1851–1856. [PubMed] [Google Scholar]
  5. Hocken A. G., Marwah P. K. Iatrogenic contribution to anaemia of chronic renal failure. Lancet. 1971 Jan 23;1(7691):164–165. doi: 10.1016/s0140-6736(71)91935-0. [DOI] [PubMed] [Google Scholar]
  6. LANGDELL R. D., WAGNER R. H., BRINKHOUS K. M. Effect of antihemophilic factor on one-stage clotting tests; a presumptive test for hemophilia and a simple one-stage antihemophilic factor assy procedure. J Lab Clin Med. 1953 Apr;41(4):637–647. [PubMed] [Google Scholar]
  7. Lyman D. J., Brash J. L., Chaikin S. W., Klein K. G., Carini M. The effect of chemical structure and surface properties of synthetic polymers on the coagulation of blood. II. Protein and platelet interaction with polymer surfaces. Trans Am Soc Artif Intern Organs. 1968;14:250–255. [PubMed] [Google Scholar]
  8. MCNICOL G. P., BARAKAT A. A., DOUGLAS A. S. PLASMA FIBRINOLYTIC ACTIVITY IN RENAL DISEASE. Scott Med J. 1965 May;10:189–194. doi: 10.1177/003693306501000502. [DOI] [PubMed] [Google Scholar]
  9. Merskey C., Kleiner G. J., Johnson A. J. Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood. 1966 Jul;28(1):1–18. [PubMed] [Google Scholar]
  10. PROCTOR R. R., RAPAPORT S. I. The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies. Am J Clin Pathol. 1961 Sep;36:212–219. doi: 10.1093/ajcp/36.3.212. [DOI] [PubMed] [Google Scholar]
  11. Salzman E. W. Summation: cellular reactions to the surface. Fed Proc. 1971 Sep-Oct;30(5):1705–1708. [PubMed] [Google Scholar]

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