Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1972 Dec 23;4(5842):694–696. doi: 10.1136/bmj.4.5842.694

Changes of Blood Pressure, Renin, and Angiotensin after Bilateral Nephrectomy in Patients with Chronic Renal Failure

A Medina, P R F Bell, J D Briggs, J J Brown, A Fine, A F Lever, J J Morton, A M Paton, J I S Robertson, M Tree, M A Waite, R Weir, J Winchester
PMCID: PMC1786871  PMID: 4345868

Abstract

Circulating levels of renin, angiotensin I, and angiotensin II were increased in six patients with chronic renal failure and hypertension uncontrolled by dialysis and hypotensive drugs. Lower and often normal levels were found in 10 patients whose blood pressure was controlled by dialysis treatment. For a variety of reasons all patients were subjected to bilateral nephrectomy. The logarithm of the decrease in plasma concentrations of renin and angiotensin II was significantly related to the fall of blood pressure after operation. Plasma renin concentration correlated significantly with blood angiotensin I concentration and with plasma angiotensin II in samples taken before and after nephrectomy. Renin, angiotensin I, and angiotensin II were measurable in samples of blood taken 48 hours or more after the operation.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bianchi G., Ponticelli C., Bardi U., Redaelli B., Campolo L., De Ponti C., Graziani G. Role of the kidney in 'salt and water dependent hypertension' of end-stage disease. Clin Sci. 1972 Jan;42(1):47–55. doi: 10.1042/cs0420047. [DOI] [PubMed] [Google Scholar]
  2. Blaufox M. D., Birbari A. E., Hickler R. B., Merrill J. P. Peripheral plasma renin activity in renal-homotransplant recipients. N Engl J Med. 1966 Nov 24;275(21):1165–1168. doi: 10.1056/NEJM196611242752105. [DOI] [PubMed] [Google Scholar]
  3. Blumberg A., Nelp W. B., Hegstrom R. M., Scribner B. H. Extracellular volume in patients with chronic renal disease treated for hypertension by sodium restriction. Lancet. 1967 Jul 8;2(7506):69–73. doi: 10.1016/s0140-6736(67)92061-2. [DOI] [PubMed] [Google Scholar]
  4. Brown J. J., Curtis J. R., Lever A. F., Robertson J. I., De Wardener H. E., Wing A. J. Plasma renin concentration and the control of blood pressure in patients on maintenance haemodialysis. Nephron. 1969;6(3):329–349. doi: 10.1159/000179737. [DOI] [PubMed] [Google Scholar]
  5. Brown J. J., Davies D. L., Lever A. F., Robertson J. I., Tree M. The estimation of renin in human plasma. Biochem J. 1964 Dec;93(3):594–600. doi: 10.1042/bj0930594. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Brown J. J., Düsterdieck G., Fraser R., Lever A. F., Robertson J. I., Tree M., Weir R. J. Hypertension and chronic renal failure. Br Med Bull. 1971 May;27(2):128–135. doi: 10.1093/oxfordjournals.bmb.a070835. [DOI] [PubMed] [Google Scholar]
  7. Capelli J. P., Wesson L. G., Jr, Aponte G. E., Faraldo C., Jaffe E. Characterization and source of a renin-like enzyme in anephric humans. J Clin Endocrinol Metab. 1968 Feb;28(2):221–230. doi: 10.1210/jcem-28-2-221. [DOI] [PubMed] [Google Scholar]
  8. Düsterdieck G., McElwee G. Estimation of angiotensin II concentration in human plasma by radioimmunoassay. Some applications to physiological and clinical states. Eur J Clin Invest. 1971 Nov;2(1):32–38. doi: 10.1111/j.1365-2362.1971.tb00565.x. [DOI] [PubMed] [Google Scholar]
  9. GROSS F., SCHAECHTELIN G., ZIEGLER M., BERGER M. A RENIN-LIKE SUBSTANCE IN THE PLACENTA AND UTERUS OF THE RABBIT. Lancet. 1964 Apr 25;1(7339):914–916. doi: 10.1016/s0140-6736(64)91637-x. [DOI] [PubMed] [Google Scholar]
  10. LEVER A. F., ROBERTSON J. I. RENIN IN THE PLASMA OF NORMAL AND HYPERTENSIVE RABBITS. J Physiol. 1964 Jan;170:212–218. doi: 10.1113/jphysiol.1964.sp007324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lazarus J. M., Hampers C. L., Bennett A. H., Vandam L. D., Merrill J. P. Urgent bilateral nephrectomy for severe hypertension. Ann Intern Med. 1972 May;76(5):733–739. doi: 10.7326/0003-4819-76-5-733. [DOI] [PubMed] [Google Scholar]
  12. Ledingham J. M. Blood-pressure regulation in renal failure. J R Coll Physicians Lond. 1971 Jan;5(2):103–134. [PMC free article] [PubMed] [Google Scholar]
  13. Mahony J. F., Gibson G. R., Sheil A. G., Storey B. G., Stokes G. S., Stewart J. H. Bilateral nephrectomy for malignant hypertension. Lancet. 1972 May 13;1(7759):1036–1038. doi: 10.1016/s0140-6736(72)91219-6. [DOI] [PubMed] [Google Scholar]
  14. Molzahn M., Dissmann T., Halim S., Lohmann F. W., Oelkers W. Orthostatic changes of haemodynamics, renal function, plasma catecholamines and plasma renin concentration in normal and hypertensive man. Clin Sci. 1972 Feb;42(2):209–222. doi: 10.1042/cs0420209. [DOI] [PubMed] [Google Scholar]
  15. Onesti G., Swartz C., Ramirez O., Brest A. N. Bilateral nephrectomy for control of hypertension in uremia. Trans Am Soc Artif Intern Organs. 1968;14:361–366. [PubMed] [Google Scholar]
  16. Stokes G. S., Mani M. K., Stewart J. H. Relevance of salt, water, and renin to hypertension in chronic renal failure. Br Med J. 1970 Jul 18;3(5715):126–129. doi: 10.1136/bmj.3.5715.126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Verniory A., Potvliege P., Van Geertruyden J. J., Vereerstraeten P., Kinnaert P., Staroukine M., Toussaint C. Renin and control of arterial blood pressure during terminal renal failure treated by haemodialysis and by transplantation. Clin Sci. 1972 Jun;42(6):685–700. doi: 10.1042/cs0420685. [DOI] [PubMed] [Google Scholar]
  18. Wilkinson R., Scott D. F., Uldall P. R., Kerr D. N., Swinney J. Plasma renin and exchangeable sodium in the hypertension of chronic renal failure. The effect of bilateral nephrectomy. Q J Med. 1970 Jul;39(155):377–394. [PubMed] [Google Scholar]
  19. Yu R., Anderton J., Skinner S. L., Best J. B. Renin in anephric man. Case report with physiologic studies. Am J Med. 1972 May;52(5):707–711. doi: 10.1016/0002-9343(72)90061-7. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES