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. 1972 Dec 16;4(5841):635–638. doi: 10.1136/bmj.4.5841.635

Early Clinical Experience with Bleomycin in the United Kingdom in Series of 105 Patients

K E Halnan, N M Bleehen, T B Brewin, T J Deeley, D F N Harrison, C Howland, P B Kunkler, G L Ritchie, E Wiltshaw, I D H Todd
PMCID: PMC1786940  PMID: 4118975

Abstract

The results of treating a series of 105 patients (79 with advanced squamous cell carcinoma, 21 with advanced lymphoma, and 5 with miscellaneous tumours) with bleomycin are described. The drug was usually given as a single agent. Four patients with squamous cell carcinoma showed complete regression and there was partial regression in 25. Side effects were frequent, particularly skin changes and stomatitis; death from pneumonitis occurred in one patient.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FOYE L. V., Jr, WILLETT F. M., HALL B., ROTH M. The potentiation of radiation effects with 5-fluoro-uracil. Calif Med. 1960 Nov;93:288–290. [PMC free article] [PubMed] [Google Scholar]
  2. Host H., Berdal P., Brennhovd I. O., Ekroll T. Kliniske erfaringer med bleomycin--et nytt cytostatikum ved cancer. Tidsskr Nor Laegeforen. 1971 Apr 10;91(10):714–passim. [PubMed] [Google Scholar]
  3. Ichikawa T., Nakano I., Hirokawa I. Bleomycin treatment of the tumors of penis and scrotum. J Urol. 1969 Dec;102(6):699–707. doi: 10.1016/s0022-5347(17)62235-3. [DOI] [PubMed] [Google Scholar]
  4. Jorgensen J. Røntgenologiske lungeforandringer under bleomycinbehandling. Ugeskr Laeger. 1971 Feb 26;133(8):342–345. [PubMed] [Google Scholar]
  5. Kligerman M. M., Hellman S., Bertino J. R., Von Essen C. F. Sequential chemotherapy and radiotherapy. Preliminary results of clinical trial with methotrexate in head and neck cancer. Radiology. 1966 Feb;86(2):247–250. doi: 10.1148/86.2.247. [DOI] [PubMed] [Google Scholar]
  6. Mitchell M. S., Wawro N. W., DeConti R. C., Kaplan S. R., Papac R., Bertino J. R. Effectiveness of high-dose infusions of methotrexate followed by leucovorin in carcinoma of the head and neck. Cancer Res. 1968 Jun;28(6):1088–1094. [PubMed] [Google Scholar]
  7. Rygård J., Hansen H. S., Jensen K. B., Aastrup J., Jorgensen S. J., Blichert-Toft M., Floystrup T., Gerlith A. Bleomycin. En praeliminaer meddelelse om et nyt antitumor-antibiotikum. Ugeskr Laeger. 1971 Feb 26;133(8):335–342. [PubMed] [Google Scholar]
  8. Umezawa H., Maeda K., Takeuchi T., Okami Y. New antibiotics, bleomycin A and B. J Antibiot (Tokyo) 1966 Sep;19(5):200–209. [PubMed] [Google Scholar]

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