Abstract
The sebum excretion rate (S.E.R.) was measured in 20 patients with acromegaly. Eleven were untreated at the time of the measurement and nine had previously undergone surgical hypophysectomy or had received pituitary irradiation by yttrium-90 or radiotherapy. In five patients the S.E.R. was measured before and after such treatment. The mean S.E.R. in the untreated acromegalics was much greater than in a normal population and decreased significantly after successful pituitary ablation. No significant decrease in mean S.E.R. occurred in the group of patients with a poor clinical response to ablation. The correlations between S.E.R. and log serum growth hormone, plasma 11-hydroxycorticosteroid levels, and heel-pad thickness were significant, but there was no significant correlation between S.E.R. and serum protein-bound iodine levels. This suggests that the changes in S.E.R. were due to pituitary ablation but could not necessarily be attributed solely to changes in growth hormone, thyroid-stimulating hormone, or adrenocorticotrophic hormone. The association between the clinical state of the acromegaly and the S.E.R. was better than the association between acromegaly and serum growth hormone. We conclude that the S.E.R. is a useful addition to the clinical and endocrinological data used in assessing acromegaly.
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Selected References
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- Cunliffe W. J., Shuster S. The rate of sebum excretion in man. Br J Dermatol. 1969 Sep;81(9):697–704. doi: 10.1111/j.1365-2133.1969.tb16211.x. [DOI] [PubMed] [Google Scholar]
- Ebling F. J., Ebling E., Skinner J., White A. The response of the sebaceous glands of hypophysectomized-castrated male rats to adrenocorticotrophic hormone and to testosterone. J Endocrinol. 1970 Sep;48(1):73–81. doi: 10.1677/joe.0.0480073. [DOI] [PubMed] [Google Scholar]
- HARTOG M., GAAFAR M. A., FRASER R. EFFECT OF CORTICOSTEROIDS ON SERUM GROWTH HORMONE. Lancet. 1964 Aug 22;2(7356):376–378. doi: 10.1016/s0140-6736(64)90389-7. [DOI] [PubMed] [Google Scholar]
- LASHER N., LORINCZ A. L., ROTHMAN S. Hormonal effects on sebaceous glands in the white rat. II. The effect of the pituitary-adrenal axis. J Invest Dermatol. 1954 Jan;22(1):25-9; discussion, 29-31. doi: 10.1038/jid.1954.6. [DOI] [PubMed] [Google Scholar]
- MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nikkari T., Valavaara M. The production of sebum in young rats: effects of age, sex, hypophysectomy and treatment with somatotrophic hormone and sex hormones. J Endocrinol. 1969 Jan;43(1):113–118. doi: 10.1677/joe.0.0430113. [DOI] [PubMed] [Google Scholar]
- STEINBACH H. L., RUSSELL W. MEASUREMENT OF THE HEEL-PAD AS AN AID TO DIAGNOSIS OF ACROMEGALY. Radiology. 1964 Mar;82:418–423. doi: 10.1148/82.3.418. [DOI] [PubMed] [Google Scholar]
- Thody A. J., Shuster S. Effect of adrenalectomy and adrenocorticotrophic hormone on sebum secretion in the rat. J Endocrinol. 1971 Feb;49(2):325–328. doi: 10.1677/joe.0.0490325. [DOI] [PubMed] [Google Scholar]
- Thody A. J., Shuster S. Sebotrophic activity of beta-lipotrophin. J Endocrinol. 1971 Jul;50(3):533–534. doi: 10.1677/joe.0.0500533. [DOI] [PubMed] [Google Scholar]
- Thody A. J., Shuster S. The pituitary and sebaceous gland activity. J Endocrinol. 1970 Sep;48(1):139–140. doi: 10.1677/joe.0.0480139. [DOI] [PubMed] [Google Scholar]