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. 1972 Mar 11;1(5801):660–662. doi: 10.1136/bmj.1.5801.660

Immediate Effects of Intravenous Verapamil in Cardiac Arrhythmias

L Schamroth, D M Krikler, C Garrett
PMCID: PMC1787795  PMID: 5015294

Abstract

Verapamil was administered by intravenous injection to 181 patients with various cardiac arrhythmias. The automaticity of the cardiac pacemaker was slowed in sinus, idionodal, and idioventricular tachycardia. In atrial fibrillation the drug usually slowed the ventricular response and often made it regular. In some cases atrial flutter was converted to sinus rhythm, the ventricular response being reduced in the remainder. Conversion of paroxysmal supraventricular tachycardia to sinus rhythm was consistently achieved. A favourable response occurred in four patients in whom arrhythmias were associated with pre-excitation syndromes. There were no adverse clinical side effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bender F. Isoptin zur Behandlung der tachykarden Form des Vorhofflatterns. Med Klin. 1967 Apr 21;62(16):634–636. [PubMed] [Google Scholar]
  2. Bender F., Kojima N., Reploh H. D., Oelmann G. Behandlung tachykarder Rhythmusstörungen des Herzens durch Beta-Rezeptorenblockade des Atrioventrikulargewebes. Med Welt. 1966 May 14;20:1120–1123. [PubMed] [Google Scholar]
  3. Bender F., Zimmerhof K. Wenckebachsche Periode als Zeichen der Uberdosierung eines Mittels mit sympathikolytischer Herzwirkung. Med Welt. 1967 Jul 1;26:1585–1587. [PubMed] [Google Scholar]
  4. Brichard G., Zimmermann P. E. Verapamil in cardiac dysrhythmias during anaesthesia. Br J Anaesth. 1970 Nov;42(11):1005–1012. doi: 10.1093/bja/42.11.1005. [DOI] [PubMed] [Google Scholar]
  5. Fleckenstein A., Döring H. J., Kammermeier H. Einfluss von Beta-Receptorenblockern und verwandten Substanzen auf Erregung, Kontraktion und Energiestoffwechsel der Myokardfaser. Klin Wochenschr. 1968 Apr 1;46(7):343–351. doi: 10.1007/BF01734125. [DOI] [PubMed] [Google Scholar]
  6. Gibson D. G., Broder G., Sowton E. Effect of varying pulse interval in atrial fibrillation on left ventricular function in man. Br Heart J. 1971 May;33(3):388–393. doi: 10.1136/hrt.33.3.388. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HOFFMANN P. BEHANDLUNG KORONARER DURCHBLUTUNGSSTOERUNGEN MIT ISOPTIN IN DER PRAXIS. Med Klin. 1964 Aug 28;59:1387–1391. [PubMed] [Google Scholar]
  8. Hills E. A. Iproveratril and bronchial asthma. Br J Clin Pract. 1970 Mar;24(3):116–117. [PubMed] [Google Scholar]
  9. Janse M. J. Influence of the direction of the atrial wave front on A-V nodal transmission in isolated hearts of rabbits. Circ Res. 1969 Oct;25(4):439–449. doi: 10.1161/01.res.25.4.439. [DOI] [PubMed] [Google Scholar]
  10. MELVILLE K. I., SHISTER H. E., HUQ S. IPROVERATRIL: EXPERIMENTAL DATA ON CORONARY DILATATION AND ANTIARRHYTHMIC ACTION. Can Med Assoc J. 1964 Mar 28;90:761–770. [PMC free article] [PubMed] [Google Scholar]
  11. Rodrigues-Pereira E., Viana A. P. The actions of verapamil on experimental arrhythmias. Arzneimittelforschung. 1968 Feb;18(2):175–179. [PubMed] [Google Scholar]
  12. Ross G., Jorgensen C. R. Cardiovascular actions of iproveratril. J Pharmacol Exp Ther. 1967 Dec;158(3):504–509. [PubMed] [Google Scholar]
  13. Sandler G., Clayton G. A., Thornicroft S. G. Clinical evaluation of verapamil in angina pectoris. Br Med J. 1968 Jul 27;3(5612):224–227. doi: 10.1136/bmj.3.5612.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Schamroth L. Immediate effects of intravenous verapamil on atrial fibrillation. Cardiovasc Res. 1971 Oct;5(4):419–424. doi: 10.1093/cvr/5.4.419. [DOI] [PubMed] [Google Scholar]

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