Skip to main content
PMC home page
British Medical Journal logoLink to British Medical Journal
. 1972 May 20;2(5811):436–438. doi: 10.1136/bmj.2.5811.436

Heparin in the Prevention of Deep Vein Thrombosis after Myocardial Infarction

Anthony J Handley, Peter A Emerson, P R Fleming
PMCID: PMC1788022  PMID: 4555651

Abstract

A trial of continuous intravenous heparin in the prevention of deep vein thrombosis was undertaken in 48 patients who had suffered a myocardial infarction. Of the 24 control patients who did not receive heparin seven (29%) developed calf vein thrombosis as detected by the radioactive fibrinogen technique. None of the 24 heparinized patients had any evidence of venous thrombosis. This difference is significant at the 1% level.

Full text

PDF
436

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Browse N. L., Clapham W. F., Croft D. N., Jones D. J., Thomas M. L., Williams J. O. Diagnosis of established deep vein thrombosis with the 125 I fibrinogen uptake test. Br Med J. 1971 Nov 6;4(5783):325–328. doi: 10.1136/bmj.4.5783.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Flanc C., Kakkar V. V., Clarke M. B. The detection of venous thrombosis of the legs using 125-I-labelled fibrinogen. Br J Surg. 1968 Oct;55(10):742–747. doi: 10.1002/bjs.1800551007. [DOI] [PubMed] [Google Scholar]
  3. Flute P. T. Deep vein thrombosis: medical management. Br Med J. 1969 Dec 13;4(5684):678–680. doi: 10.1136/bmj.4.5684.678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gerson C. D., Janowitz H. D. Glucose therapy in short-bowel syndrome. Lancet. 1971 Nov 13;2(7733):1098–1098. doi: 10.1016/s0140-6736(71)90421-1. [DOI] [PubMed] [Google Scholar]
  5. Handley A. J. Management of deep vein thrombosis. Br Med J. 1970 Jan 24;1(5690):234–234. doi: 10.1136/bmj.1.5690.234-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Handley A. J. Portable heparin injector. Lancet. 1970 Aug 8;2(7667):313–314. [PubMed] [Google Scholar]
  7. Johnson D. C., Reeve T. S. The effects and clinical significance of heparin and phenindione on a standard experimental femoral venous thrombus. Aust N Z J Surg. 1969 Nov;39(2):209–216. doi: 10.1111/j.1445-2197.1969.tb05591.x. [DOI] [PubMed] [Google Scholar]
  8. Kakkar V. V., Howe C. T., Flanc C., Clarke M. B. Natural history of postoperative deep-vein thrombosis. Lancet. 1969 Aug 2;2(7614):230–232. doi: 10.1016/s0140-6736(69)90002-6. [DOI] [PubMed] [Google Scholar]
  9. Kakkar V. V., Nicolaides A. N., Renney J. T., Friend J. R., Clarke M. B. 125-I-labelled fibrinogen test adapted for routine screening for deep-vein thrombosis. Lancet. 1970 Mar 14;1(7646):540–542. doi: 10.1016/s0140-6736(70)90769-5. [DOI] [PubMed] [Google Scholar]
  10. Lambie J. M., Mahaffy R. G., Barber D. C., Karmody A. M., Scott M. M., Matheson N. A. Diagnostic accuracy in venous thrombosis. Br Med J. 1970 Apr 18;2(5702):142–143. doi: 10.1136/bmj.2.5702.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Martyn D. T., Janes J. M. Continuous intravenous administration of heparin. Mayo Clin Proc. 1971 May;46(5):347–351. [PubMed] [Google Scholar]
  12. Maurer B. J., Wray R., Shillingford J. P. Frequency of venous thrombosis after myocardial infarction. Lancet. 1971 Dec 25;2(7739):1385–1387. doi: 10.1016/s0140-6736(71)90666-0. [DOI] [PubMed] [Google Scholar]
  13. Murray T. S., Lorimer A. R., Cox F. C., Lawrie T. D. Leg-vein thrombosis following myocardial infarction. Lancet. 1970 Oct 17;2(7677):792–793. doi: 10.1016/s0140-6736(70)91459-5. [DOI] [PubMed] [Google Scholar]
  14. Negus D., Pinto D. J., Le Quesne L. P., Brown N., Chapman M. 125-I-labelled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebography. Br J Surg. 1968 Nov;55(11):835–839. [PubMed] [Google Scholar]
  15. Norris R. M., Brandt P. W., Caughey D. E., Lee A. J., Scott P. J. A new coronary prognostic index. Lancet. 1969 Feb 8;1(7589):274–278. doi: 10.1016/s0140-6736(69)91035-6. [DOI] [PubMed] [Google Scholar]
  16. Peel A. A., Semple T., Wang I., Lancaster W. M., Dall J. L. A CORONARY PROGNOSTIC INDEX FOR GRADING THE SEVERITY OF INFARCTION. Br Heart J. 1962 Nov;24(6):745–760. doi: 10.1136/hrt.24.6.745. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Postoperative deep venous thrombosis: comparison of diagnostic techniques. Lancet. 1971 Oct 2;2(7727):763–764. [PubMed] [Google Scholar]
  18. Sharnoff J. G., DeBlasio G. Prevention of fatal postoperative thromboembolism by heparin prophylaxis. Lancet. 1970 Nov 14;2(7681):1006–1007. doi: 10.1016/s0140-6736(70)92815-1. [DOI] [PubMed] [Google Scholar]
  19. Williams H. T. Prevention of postoperative deep-vein thrombosis with perioperative subcutaneous heparin. Lancet. 1971 Oct 30;2(7731):950–952. doi: 10.1016/s0140-6736(71)90270-4. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES