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. 1972 Jun 3;2(5813):556–561. doi: 10.1136/bmj.2.5813.556

Varicose Veins, Deep Vein Thrombosis, and Haemorrhoids: Epidemiology and Suggested Aetiology

Denis P Burkitt
PMCID: PMC1788140  PMID: 5032782

Abstract

Current concepts on the aetiology of varicose veins, deep vein thrombosis, and haemorrhoids have been examined and, in the light of epidemiological evidence, found wanting.

It is suggested that the fundamental cause of these disorders is faecal arrest which is the result of a low-residue diet.

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Selected References

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  1. BARLOW M. B., GINSBERG H., GOTTLICH J. Deaths at a non-European hospital (1945-1951); a review. S Afr Med J. 1953 Mar 21;27(12):242–246. [PubMed] [Google Scholar]
  2. Browse N. L., Negus D. Prevention of postoperative leg vein thrombosis by electrical muscle stimulation. An evaluation with 125I-labelled fibrinogen. Br Med J. 1970 Sep 12;3(5723):615–618. doi: 10.1136/bmj.3.5723.615. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burkitt D. P. Epidemiology of cancer of the colon and rectum. Cancer. 1971 Jul;28(1):3–13. doi: 10.1002/1097-0142(197107)28:1<3::aid-cncr2820280104>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  4. Burkitt D. P. Related disease--related cause? Lancet. 1969 Dec 6;2(7632):1229–1231. doi: 10.1016/s0140-6736(69)90757-0. [DOI] [PubMed] [Google Scholar]
  5. Burkitt D. P. Relationship as a clue to causation. Lancet. 1970 Dec 12;2(7685):1237–1240. doi: 10.1016/s0140-6736(70)92195-1. [DOI] [PubMed] [Google Scholar]
  6. CLEAVE T. L. Varicose veins, nature's error or man's? Some implications of the Darwinian theory. Lancet. 1959 Aug 22;2(7095):172–175. doi: 10.1016/s0140-6736(59)90577-x. [DOI] [PubMed] [Google Scholar]
  7. COON W. W., COLLER F. A. Some epidemiologic considerations of thromboembolism. Surg Gynecol Obstet. 1959 Oct;109:487–501. [PubMed] [Google Scholar]
  8. Calnan J. S., Pflug J. J., Mills C. J. Pneumatic intermittent-compression legging simulating calf-muscle pump. Lancet. 1970 Sep 5;2(7671):502–503. doi: 10.1016/s0140-6736(70)90118-2. [DOI] [PubMed] [Google Scholar]
  9. Campbell G. D., Cleave T. L. Diverticular disease of the colon. Br Med J. 1968 Sep 21;3(5620):741–741. doi: 10.1136/bmj.3.5620.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Chakrabarti R., Hocking E. D., Fearnley G. R., Mann R. D., Attwell T. N., Jackson D. Fibrinolytic activity and coronary-artery disease. Lancet. 1968 May 11;1(7550):987–990. doi: 10.1016/s0140-6736(68)91104-5. [DOI] [PubMed] [Google Scholar]
  11. Clark C., Cotton L. T. Blood-flow in deep veins of leg. Recording technique and evaluation of methods to increase flow during operation. Br J Surg. 1968 Mar;55(3):211–214. doi: 10.1002/bjs.1800550312. [DOI] [PubMed] [Google Scholar]
  12. DODD H. THE CAUSE, PREVENTION, AND ARREST OF VARICOSE VEINS. Lancet. 1964 Oct 10;2(7363):809–811. doi: 10.1016/s0140-6736(64)90579-3. [DOI] [PubMed] [Google Scholar]
  13. DORAN F. S., DRURY M., SIVYER A. A SIMPLE WAY TO COMBAT THE VENOUS STASIS WHICH OCCURS IN THE LOWER LIMBS DURING SURGICAL OPERATIONS. Br J Surg. 1964 Jul;51:486–492. doi: 10.1002/bjs.1800510705. [DOI] [PubMed] [Google Scholar]
  14. Doran F. S., White M., Drury M. A clinical trial designed to test the relative value of two simple methods of reducing the risk of venous stasis in the lower limbs during surgical operations, the danger of thrombosis, and a subsequent pulmonary embolus, with a survey of the problem. Br J Surg. 1970 Jan;57(1):20–30. doi: 10.1002/bjs.1800570105. [DOI] [PubMed] [Google Scholar]
  15. Flanc C., Kakkar V. V., Clarke M. B. Postoperative deep-vein thrombosis. Effect of intensive prophylaxis. Lancet. 1969 Mar 8;1(7593):477–478. doi: 10.1016/s0140-6736(69)91585-2. [DOI] [PubMed] [Google Scholar]
  16. GIBBS N. M. The prophylaxis of pulmonary embolism. A clinical programme. Br J Surg. 1959 Nov;47:282–287. doi: 10.1002/bjs.18004720320. [DOI] [PubMed] [Google Scholar]
  17. Kakkar V. V., Howe C. T., Nicolaides A. N., Renney J. T., Clarke M. B. Deep vein thrombosis of the leg. Is there a "high risk" group? Am J Surg. 1970 Oct;120(4):527–530. doi: 10.1016/s0002-9610(70)80023-x. [DOI] [PubMed] [Google Scholar]
  18. Lambie J. M., Mahaffy R. G., Barber D. C., Karmody A. M., Scott M. M., Matheson N. A. Diagnostic accuracy in venous thrombosis. Br Med J. 1970 Apr 18;2(5702):142–143. doi: 10.1136/bmj.2.5702.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Little J. M., Loewenthal J., Mills F. H. Venous thrombo-embolic disease. Br J Surg. 1966 Aug;53(8):657–667. doi: 10.1002/bjs.1800530803. [DOI] [PubMed] [Google Scholar]
  20. MORRELL M. T., TRUELOVE S. C., BARR A. PULMONARY EMBOLISM. Br Med J. 1963 Oct 5;2(5361):830–835. doi: 10.1136/bmj.2.5361.830. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Mavor G. E. Deep vein thrombosis: surgical management. Br Med J. 1969 Dec 13;4(5684):680–682. doi: 10.1136/bmj.4.5684.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Mekky S., Schilling R. S., Walford J. Varicose veins in women cotton workers. An epidemiological study in England and Egypt. Br Med J. 1969 Jun 7;2(5657):591–595. doi: 10.1136/bmj.2.5657.591. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Negus D., Pinto D. J., Brown N. 125-I-labelled fibrinogen in the diagnosis of deep-vein thrombosis. Acta Chir Belg. 1969 Oct;68(7):507–515. [PubMed] [Google Scholar]
  24. Negus D. The post-thrombotic syndrome. Ann R Coll Surg Engl. 1970 Aug;47(2):92–105. [PMC free article] [PubMed] [Google Scholar]
  25. Nicolaides A. N., Kakkar V. V., Renney J. T., Kidner P. H., Hutchison D. C., Clarke M. B. Myocardial infarction and deep-vein thrombosis. Br Med J. 1971 Feb 20;1(5746):432–434. doi: 10.1136/bmj.1.5746.432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Painter N. S., Almeida A. Z., Colebourne K. W. Unprocessed bran in treatment of diverticular disease of the colon. Br Med J. 1972 Apr 15;2(5806):137–140. doi: 10.1136/bmj.2.5806.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Painter N. S., Burkitt D. P. Diverticular disease of the colon: a deficiency disease of Western civilization. Br Med J. 1971 May 22;2(5759):450–454. doi: 10.1136/bmj.2.5759.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Painter N. S. Diverticular disease of the colon--a disease of the century. Lancet. 1969 Sep 13;2(7620):586–588. doi: 10.1016/s0140-6736(69)90278-5. [DOI] [PubMed] [Google Scholar]
  30. RHODES P. POSTOPERATIVE PROPHYLACTIC ANTICOAGULANTS IN GYNAECOLOGY. Lancet. 1964 Oct 31;2(7366):970–970. doi: 10.1016/s0140-6736(64)90916-x. [DOI] [PubMed] [Google Scholar]
  31. Richards R. L. Diseases of the heart and blood-vessels. Venous thrombosis. Br Med J. 1966 Jul 23;2(5507):217–219. doi: 10.1136/bmj.2.5507.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Roberts V. C., Sabri S., Pietroni M. C., Gurewich V., Cotton L. T. Passive flexion and femoral vein flow: a study using a motorized foot mover. Br Med J. 1971 Jul 10;3(5766):78–81. doi: 10.1136/bmj.3.5766.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. SEVITT S., GALLAGHER N. G. Prevention of venous thrombosis and pulmonary embolism in injured patients. A trial of anticoagulant prophylaxis with phenindione in middle-aged and elderly patients with fractured necks of femur. Lancet. 1959 Dec 5;2(7110):981–989. doi: 10.1016/s0140-6736(59)91464-3. [DOI] [PubMed] [Google Scholar]
  34. SEVITT S., GALLAGHER N. Venous thrombosis and pulmonary embolism. A clinico-pathological study in injured and burned patients. Br J Surg. 1961 Mar;48:475–489. doi: 10.1002/bjs.18004821103. [DOI] [PubMed] [Google Scholar]
  35. Sabri S., Roberts V. C., Cotton L. T. Prevention of early postoperative deep vein thrombosis by passive exercise of leg during surgery. Br Med J. 1971 Jul 10;3(5766):82–83. doi: 10.1136/bmj.3.5766.82. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Shaper A. G., Jones K. W., Kyobe J., Jones M. Fibrinolysis in relation to body fatness, serum lipids and coronary heart disease in African and Asian men in Uganda. J Atheroscler Res. 1966 Jul-Aug;6(4):313–327. doi: 10.1016/s0368-1319(66)80043-1. [DOI] [PubMed] [Google Scholar]
  37. Sripad S., Antcliff A. C., Martin P. Deep-vein thrombosis in two district hospitals in Essex. Br J Surg. 1971 Aug;58(8):563–565. doi: 10.1002/bjs.1800580803. [DOI] [PubMed] [Google Scholar]
  38. THOMAS W. A., DAVIES J. N., O'NEAL R. M., DIMAKULANGAN A. A. Incidence of myocardial infarction correlated with venous and pulmonary thrombosis and embolism. A geographic study based on autopsies in Uganda. East Africa and St. Louis, U.S.A. Am J Cardiol. 1960 Jan;5:41–47. doi: 10.1016/0002-9149(60)90007-2. [DOI] [PubMed] [Google Scholar]
  39. WALKER A. R. Crude fibre, bowel motility, and pattern of diet. S Afr Med J. 1961 Feb 11;35:114–115. [PubMed] [Google Scholar]
  40. WRIGHT H. P., OSBORN S. B., EDMONDS D. G. Effect of postoperative bed rest and early ambulation on the rate of venous blood-flow. Lancet. 1951 Jan 6;1(6645):22–25. doi: 10.1016/s0140-6736(51)93496-4. [DOI] [PubMed] [Google Scholar]
  41. Walker A. R. Diet, bowel motility, faeces composition and colonic cancer. S Afr Med J. 1971 Apr 3;45(14):377–379. [PubMed] [Google Scholar]
  42. Wilson L. B. I. Fatal Post-Operative Embolism. Ann Surg. 1912 Dec;56(6):809–817. doi: 10.1097/00000658-191212000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]

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