Abstract
Immunological responses were studied in pregnant women and controls using as tests phytohaemagglutinin-induced lymphocyte transformation and the tuberculin reaction. Significantly reduced responses were found to both tests in the pregnant women. These results suggest that a reduction in T-cell activity during pregnancy may help protect the fetus from rejection by its mother's immunological mechanisms.
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Selected References
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- Anderson J. M., Ferguson-Smith M. A. Nature's transplant. Br Med J. 1971 Apr 17;2(5754):166–167. doi: 10.1136/bmj.2.5754.166-c. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Anderson J. M. Transplantation--nature's success. Lancet. 1971 Nov 13;2(7733):1077–1082. doi: 10.1016/s0140-6736(71)90394-1. [DOI] [PubMed] [Google Scholar]
- Astaldi G., Burgio G. R., Krc J., Genova R., Astaldi A. A., Jr L-asparaginase and blastogenesis. Lancet. 1969 Feb 22;1(7591):423–423. doi: 10.1016/s0140-6736(69)91400-7. [DOI] [PubMed] [Google Scholar]
- Dudley F. J., Fox R. A., Sherlock S. Cellular immunity and hepatitis-associated, Australia antigen liver disease. Lancet. 1972 Apr 1;1(7753):723–726. doi: 10.1016/s0140-6736(72)90234-6. [DOI] [PubMed] [Google Scholar]
- Hellström K. E., Hellström I., Brawn J. Abrogation of cellular immunity to antigenically foreign mouse embryonic cells by a serum factor. Nature. 1969 Nov 29;224(5222):914–915. doi: 10.1038/224914a0. [DOI] [PubMed] [Google Scholar]
- Lanman J. T., Herod L. Homograft immunity in pregnancy. The placental transfer of cytotoxic antibody in rabbits. J Exp Med. 1965 Sep 1;122(3):579–586. doi: 10.1084/jem.122.3.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Purtilo D. T., Hallgren H. M., Yunis E. J. Depressed maternal lymphocyte response to phytohaemagglutinin in human pregnancy. Lancet. 1972 Apr 8;1(7754):769–771. doi: 10.1016/s0140-6736(72)90522-3. [DOI] [PubMed] [Google Scholar]
- Walknowska J., Conte F. A., Grumbach M. M. Practical and theoretical implications of fetal-maternal lymphocyte transfer. Lancet. 1969 Jun 7;1(7606):1119–1122. doi: 10.1016/s0140-6736(69)91642-0. [DOI] [PubMed] [Google Scholar]
- Woodrow J. C., Elson C. J., Donohoe W. T. Effect of pregnancy on the isoantibody response in rabbits. Nature. 1971 Sep 3;233(5314):62–63. doi: 10.1038/233062a0. [DOI] [PubMed] [Google Scholar]
- Woodrow J. C., Finn R. Transplacental haemorrhage. Br J Haematol. 1966 May;12(3):297–309. doi: 10.1111/j.1365-2141.1966.tb05636.x. [DOI] [PubMed] [Google Scholar]