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. 1972 Dec 2;4(5839):520–522. doi: 10.1136/bmj.4.5839.520

Viral Infection and Renal Transplant Rejection

J D Briggs, Morag C Timbury, A M Paton, P R F Bell
PMCID: PMC1788750  PMID: 4566016

Abstract

The occurrence of an outbreak of influenza in a renal transplant unit is described. Five patients had a proved episode of infection, confirmed by a rise in the complement fixation titre to influenza virus A, and this coincided in three of the patients with episodes of acute rejection. It seems likely that the virus infection was responsible for the rejection, possibly through a stimulating effect of the virus on the host's immune response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell P. R., Briggs J. D., Calman K. C., Paton A. M., Wood R. F., Macpherson S. G., Kyle K. Reversal of acute clinical and experimental organ rejection using large doses of intravenous prednisolone. Lancet. 1971 May 1;1(7705):876–880. doi: 10.1016/s0140-6736(71)92441-x. [DOI] [PubMed] [Google Scholar]
  2. David D. S., Millian S. J., Whitsell J. C., Schwartz G. H., Riggio R. R., Stenzel K. H., Rubin A. L. Viral syndromes and renal homograft rejection. Ann Surg. 1972 Feb;175(2):257–259. doi: 10.1097/00000658-197202000-00017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Field E. J., Caspary E. A. "Spontaneous" lymphocyte reactivity in the presence of virus infection. Lancet. 1972 Apr 29;1(7757):963–963. doi: 10.1016/s0140-6736(72)91531-0. [DOI] [PubMed] [Google Scholar]
  4. Galanaud P., Crevon M. C., Dormont J., Mathieu P., Weydert A. Leukocyte migration test and renal allograft rejection. Transplantation. 1972 Jan;13(1):48–52. doi: 10.1097/00007890-197201000-00012. [DOI] [PubMed] [Google Scholar]
  5. Oldstone M. B., Dixon F. J. Lymphocytic choriomeningitis: production of antibody by "tolerant" infected mice. Science. 1967 Dec 1;158(3805):1193–1195. doi: 10.1126/science.158.3805.1193. [DOI] [PubMed] [Google Scholar]
  6. Smith M. G., Eddleston A. L., Dominguez J. A., Evans D. B., Bewick M., Williams R. Changes in leucocyte migration after renal transplantation. Br Med J. 1969 Nov 1;4(5678):275–278. doi: 10.1136/bmj.4.5678.275. [DOI] [PMC free article] [PubMed] [Google Scholar]

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