Abstract
Twenty-four subjects received three oral glucose tolerance tests, in the morning, afternoon, and evening of separate days. The mean blood sugar levels in the afternoon and evening tests were similar, and they were both significantly higher than those in the morning test. Plasma immunoreactive insulin levels, however, were highest in the morning test. The pattern of insulin levels during the afternoon and evening tests resembled that described as typical of maturity-onset diabetes.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ben-Dyke R. Diurnal variation of oral glucose tolerance in volunteers and laboratory animals. Diabetologia. 1971 Jun;7(3):156–159. doi: 10.1007/BF01212547. [DOI] [PubMed] [Google Scholar]
- Bowen A. J., Reeves R. L. Diurnal variation in glucose tolerance. Arch Intern Med. 1967 Mar;119(3):261–264. [PubMed] [Google Scholar]
- Freinkel N., Mager M., Vinnick L. Cyclicity in the interrelationships between plasma insulin and glucose during starvation in normal young men. J Lab Clin Med. 1968 Jan;71(1):171–178. [PubMed] [Google Scholar]
- HELLMAN B., HELLERSTROM C. Diurnal changes in the function of the pancreatic islets of rats as indicated by nuclear size in the islet cells. Acta Endocrinol (Copenh) 1959 Jun;31(2):267–281. doi: 10.1530/acta.0.xxxi0267. [DOI] [PubMed] [Google Scholar]
- Jarrett R. J., Keen H. Diurnal variation of oral glucose tolerance: a possible pointer to the evolution of diabetes mellitus. Br Med J. 1969 May 10;2(5653):341–344. doi: 10.1136/bmj.2.5653.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jarrett R. J., Keen H. Further observations on the diurnal variation in oral glucose tolerance. Br Med J. 1970 Nov 7;4(5731):334–337. doi: 10.1136/bmj.4.5731.334. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lambert A. E., Hoet J. J. Diurnal pattern of plasma insulin concentration in the human. Diabetologia. 1966 Jun;2(1):69–72. doi: 10.1007/BF01106976. [DOI] [PubMed] [Google Scholar]
- Malherbe C., De Gasparo M., De Hertogh R., Hoet J. J. Circadian variations of blood sugar and plasma insulin levels in man. Diabetologia. 1969 Dec;5(6):397–404. doi: 10.1007/BF00427978. [DOI] [PubMed] [Google Scholar]
- ROBERTS H. J. AFTERNOON GLUCOSE TOLERANCE TESTING: A KEY TO THE PATHOGENESIS, EARLY DIAGNOSIS AND PROGNOSIS OF DIABETOGENIC HYPERINSULINISM. J Am Geriatr Soc. 1964 May;12:423–472. doi: 10.1111/j.1532-5415.1964.tb05730.x. [DOI] [PubMed] [Google Scholar]