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. 1979 Aug;20(8):201–206.

Contagious Equine Metritis: A Review

M D Eaglesome, M M Garcia
PMCID: PMC1789568  PMID: 389400

Abstract

Contagious equine metritis is a highly contagious genital infection of mares, spread venereally, and was first described in 1977. Although most contagious equine metritis outbreaks involved Thoroughbreds, infection in other breeds has also occurred. The disease has been reported in Europe, Australia and the United States. In Canada, contagious equine metritis has been designated a reportable disease under the Animal Disease and Protection Act.

Contagious equine metritis is characterized by an endometritis and infertility and infected mares show no signs of systemic infection. Clinical signs have not been observed in stallions. An asymptomatic carrier state exists in both mares and stallions.

Infected mares respond clinically to the topical and parenteral administration of antibacterial drugs. However, a proportion of mares remain carriers of the contagious equine metritis organism. Treatment of stallions is successful. Haemophilus equigenitalis has been proposed as the species name of the Gram-negative, microaerophilic coccobacillus.

Sample collection and laboratory methods for the diagnosis of contagious equine metritis are described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atherton J. G. Isolation of CEM organism. Vet Rec. 1978 Jan 21;102(3):67–67. doi: 10.1136/vr.102.3.67. [DOI] [PubMed] [Google Scholar]
  2. Benson J. A., Dawson F. L., Durrant D. S., Edwards P. T., Powell D. G. Serological response in mares affected by contagious equine metritis 1977. Vet Rec. 1978 Apr 1;102(13):277–280. doi: 10.1136/vr.102.13.277. [DOI] [PubMed] [Google Scholar]
  3. Crowhurst R. C. Genital infection in mares. Vet Rec. 1977 May 28;100(22):476–476. doi: 10.1136/vr.100.22.476-a. [DOI] [PubMed] [Google Scholar]
  4. Crowhurst R. C., Simpson D. J., Greenwood R. E., Ellis D. R. Contagious equine metritis. Vet Rec. 1978 Jan 28;102(4):91–92. doi: 10.1136/vr.102.4.91. [DOI] [PubMed] [Google Scholar]
  5. Croxton-Smith P., Benson J. A., Dawson F. L., Powell D. G. A complement fixation test for antibody to the contagious equine metritis organism. Vet Rec. 1978 Sep 23;103(13):275–278. doi: 10.1136/vr.103.13.275. [DOI] [PubMed] [Google Scholar]
  6. David J. S., Frank C. J., Powell D. G. Contagious metritis 1977. Vet Rec. 1977 Sep 3;101(10):189–190. doi: 10.1136/vr.101.10.189. [DOI] [PubMed] [Google Scholar]
  7. Dawson F. L., Benson J. A., Croxton-Smith P. The course of serum antibody development in two ponies experimentally infected with contagious metritis. Equine Vet J. 1978 Jul;10(3):145–147. doi: 10.1111/j.2042-3306.1978.tb02243.x. [DOI] [PubMed] [Google Scholar]
  8. Fernie D. S., Cayzer I., Chalmers S. R. A passive haemagglutination test for the detection of antibodies to the contagious equine metritis organism. Vet Rec. 1979 Mar 24;104(12):260–262. doi: 10.1136/vr.104.12.260. [DOI] [PubMed] [Google Scholar]
  9. Fernie D. S. Growth of the contagious equine metritis organism in a liquid medium. Vet Rec. 1978 Aug 26;103(9):187–188. doi: 10.1136/vr.103.9.187. [DOI] [PubMed] [Google Scholar]
  10. Holden C. Outbreak of Equine VD Stirs Fear in Kentucky. Science. 1978 Apr 14;200(4338):181–185. doi: 10.1126/science.200.4338.181. [DOI] [PubMed] [Google Scholar]
  11. Isolation of the CEM organism from the clitoris of the mare. Vet Rec. 1978 Jan 7;102(1):19–20. doi: 10.1136/vr.102.1.19. [DOI] [PubMed] [Google Scholar]
  12. Isolation of the CEM organism from the clitoris of the mare. Vet Rec. 1978 Jan 7;102(1):19–20. doi: 10.1136/vr.102.1.19. [DOI] [PubMed] [Google Scholar]
  13. Kilian M. A taxonomic study of the genus Haemophilus, with the proposal of a new species. J Gen Microbiol. 1976 Mar;93(1):9–62. doi: 10.1099/00221287-93-1-9. [DOI] [PubMed] [Google Scholar]
  14. O'Driscoll J. G., Troy P. T., Geoghegan F. J. An epidemic of venereal infection in thoroughbreds. Vet Rec. 1977 Oct 29;101(18):359–360. doi: 10.1136/vr.101.18.359. [DOI] [PubMed] [Google Scholar]
  15. O'Driscoll J. Venereal infection in thoroughbreds with Bacillus proteus mirabilis. Vet Rec. 1977 Jun 18;100(25):534–534. doi: 10.1136/vr.100.25.534. [DOI] [PubMed] [Google Scholar]
  16. Platt H., Atherton J. G. Contagious equine metritis. Vet Rec. 1977 Nov 19;101(21):434–434. doi: 10.1136/vr.101.21.434. [DOI] [PubMed] [Google Scholar]
  17. Platt H., Atherton J. G., Simpson D. J., Taylor C. E., Rosenthal R. O., Brown D. F., Wreghitt T. G. Genital infection in mares. Vet Rec. 1977 Jul 2;101(1):20–20. doi: 10.1136/vr.101.1.20. [DOI] [PubMed] [Google Scholar]
  18. Powell D. G. Contagious equine metritis. Equine Vet J. 1978 Jan;10(1):1–4. doi: 10.1111/j.2042-3306.1978.tb02200.x. [DOI] [PubMed] [Google Scholar]
  19. Powell D. G., David J. S., Frank C. J. Contagious equine metritis: the present situation reviewed and a revised code of practice for its control. Vet Rec. 1978 Oct 28;103(18):399–402. doi: 10.1136/vr.103.18.399. [DOI] [PubMed] [Google Scholar]
  20. Ricketts S. W., Rossdale P. D., Samuel C. A. Endometrial biopsy studies of mares with contagious equine metritis 1977. Equine Vet J. 1978 Jul;10(3):160–166. doi: 10.1111/j.2042-3306.1978.tb02247.x. [DOI] [PubMed] [Google Scholar]
  21. Ricketts S. W., Rossdale P. D., Wingfield-Digby N. J., Falk N. M., Hopes R., Hunt M. D., Peace C. K. Genital infection in mares. Vet Rec. 1977 Jul 16;101(3):65–65. doi: 10.1136/vr.101.3.65. [DOI] [PubMed] [Google Scholar]
  22. Rommel F. A., Dardiri A. H., Sahu S. P., Pierson R. E. Serological identification of the bacterial agent of contagious equine metritis. Vet Rec. 1978 Dec 16;103(25):564–564. doi: 10.1136/vr.103.25.564. [DOI] [PubMed] [Google Scholar]
  23. Shreeve J. E. Preliminary observations on X-factor growth requirement of the bacterium responsible for CEM. Vet Rec. 1978 Jan 7;102(1):20–20. doi: 10.1136/vr.102.1.20. [DOI] [PubMed] [Google Scholar]
  24. Simons M. A., Gibson M. W. Contagious equine metritis. Vet Rec. 1978 Jan 14;102(2):43–43. doi: 10.1136/vr.102.2.43-a. [DOI] [PubMed] [Google Scholar]
  25. Simpson D. J., Eaton-Evans W. E. Sites of CEM infection. Vet Rec. 1978 Jun 3;102(22):488–488. doi: 10.1136/vr.102.22.488-a. [DOI] [PubMed] [Google Scholar]
  26. Swaney L. M., Sahu S. P. CEM: bacteriological methods. Vet Rec. 1978 Jan 14;102(2):43–43. doi: 10.1136/vr.102.2.43. [DOI] [PubMed] [Google Scholar]
  27. Swerczek T. W. Contagious equine metritis in the USA. Vet Rec. 1978 Jun 10;102(23):512–513. doi: 10.1136/vr.102.23.512. [DOI] [PubMed] [Google Scholar]
  28. Swerczek T. W. Inhibition of the CEM organism by the normal flora of the reproductive tract. Vet Rec. 1978 Aug 5;103(6):125–125. doi: 10.1136/vr.103.6.125-a. [DOI] [PubMed] [Google Scholar]
  29. Taylor C. E., Rosenthal R. O. Agglutinins to the causative organism of contagious equine metritis 1977 in human serum. Lancet. 1978 May 13;1(8072):1038–1038. doi: 10.1016/s0140-6736(78)90756-0. [DOI] [PubMed] [Google Scholar]
  30. Taylor C. E., Rosenthal R. O., Brown D. F., Lapage S. P., Hill L. R., Legros R. M. The causative organism of contagious equine metritis 1977: proposal for a new species to be known as Haemophilus equigenitalis. Equine Vet J. 1978 Jul;10(3):136–144. doi: 10.1111/j.2042-3306.1978.tb02242.x. [DOI] [PubMed] [Google Scholar]
  31. Timoney P. J., Geraghty V. P., Dillon P. B., McArdle J. F. Susceptibility of laboratory animals to infection with Haemophilus equigenitalis. Vet Rec. 1978 Dec 16;103(25):563–564. doi: 10.1136/vr.103.25.563. [DOI] [PubMed] [Google Scholar]
  32. Timoney P. J., Harrington A., McArdle J., O'Reilly P. Survival properties of the causal agent of contagious equine metritis 1977. Vet Rec. 1978 Feb 18;102(7):152–152. [PubMed] [Google Scholar]
  33. Timoney P. J., McArdle J. F., O'Reilly P. J., Ward J., Harrington A. M. Successful transmission of CEM to the donkey. Vet Rec. 1979 Jan 27;104(4):84–84. doi: 10.1136/vr.104.4.84-a. [DOI] [PubMed] [Google Scholar]
  34. Timoney P. J., McArdle J. F., O'Reilly P. J., Ward J. Infection patterns in pony mares challenged with the agent of contagious equine metritis 1977. Equine Vet J. 1978 Jul;10(3):148–152. doi: 10.1111/j.2042-3306.1978.tb02244.x. [DOI] [PubMed] [Google Scholar]
  35. Timoney P. J., O'Reilly P. J., Harrington A. M., McCormack R., McArdle J. F. Contagious equine metritis and AI. Vet Rec. 1978 Dec 2;103(23):519–519. doi: 10.1136/vr.103.23.519. [DOI] [PubMed] [Google Scholar]
  36. Timoney P. J., O'Reilly P. J., McArdle J. F., Ward J., Harrington A. M. Responses of mares to rechallenge with the organism of contagious equine metritis 1977. Vet Rec. 1979 Mar 24;104(12):264–264. doi: 10.1136/vr.104.12.264. [DOI] [PubMed] [Google Scholar]
  37. Timoney P. J., O'Reilly P. J., McArdle J., Ward J. Attempted transmission of contagious equine metritis 1977 to other domestic animal species. Vet Rec. 1978 Feb 18;102(7):152–152. [PubMed] [Google Scholar]
  38. Timoney P. J., Ward J., Kelly P. A contagious genital infection of mares. Vet Rec. 1977 Jul 30;101(5):103–103. doi: 10.1136/vr.101.5.103-a. [DOI] [PubMed] [Google Scholar]
  39. Timoney P. J., Ward J., McArdle J. F. CEM and the foaling mare. Vet Rec. 1978 Mar 18;102(11):246–246. doi: 10.1136/vr.102.11.246. [DOI] [PubMed] [Google Scholar]
  40. Timoney P. J., Ward J., McArdle J. F. Daily variations in the shedding of the agent of contagious equine metritis 1977 by a carrier mare. Vet Rec. 1978 Sep 2;103(10):210–211. doi: 10.1136/vr.103.10.210. [DOI] [PubMed] [Google Scholar]

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