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. 1980 May;21(5):141–148.

Clostridium perfringens in Animal Disease: A Review of Current Knowledge

L Niilo
PMCID: PMC1789702  PMID: 6253040

Abstract

The diseases caused by various types of Clostridium perfringens are critically reviewed in the light of current knowledge. Particular emphasis is placed on information concerning these diseases in Canadian livestock.

There are two etiologically clearly-defined acute C. perfringens diseases recognized in Canada: hemorrhagic enteritis of the new born calf, caused by C. perfringens type C, and enterotoxemia of sheep, caused by type D. Clostridium perfringens type A may play a role as a secondary pathological agent in various disease conditions, such as necrotic enteritis of chickens. It may also cause wound infections and may provide a source for human food poisoning outbreaks.

There appears to be a considerable lack of knowledge regarding the distribution of C. perfringens types, their pathogenesis, diagnosis and the incidence of diseases caused by this organism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AICHELMAN W. W., BROWN G. D., GRINER L. A. Clostridium perfringens type D (epsilon) enterotoxemia in Brown Swiss dairy calves. J Am Vet Med Assoc. 1956 Oct 15;129(8):375–376. [PubMed] [Google Scholar]
  2. Al-Sheikhly F., Truscott R. B. The interaction of Clostridium perfringens and its toxins in the production of necrotic enteritis of chickens. Avian Dis. 1977 Apr-Jun;21(2):256–263. [PubMed] [Google Scholar]
  3. Al-Sheikhly F., Truscott R. B. The pathology of necrotic enteritis of chickens following infusion of broth cultures of Clostridium perfringens into the duodenum. Avian Dis. 1977 Apr-Jun;21(2):230–240. [PubMed] [Google Scholar]
  4. Al-Sheikhly F., Truscott R. B. The pathology of necrotic enteritis of chickens following infusion of crude toxins of Clostridium perfringens into the duodenum. Avian Dis. 1977 Apr-Jun;21(2):241–255. [PubMed] [Google Scholar]
  5. BUDDLE M. B. Degraded strains of Clostridium welchii type C isolated from sheep in New Zealand. J Comp Pathol. 1954 Jul;64(3):217–224. doi: 10.1016/s0368-1742(54)80024-5. [DOI] [PubMed] [Google Scholar]
  6. Barker W. H., Jr, Sagerser J. C., Hall C. V., Anderson H. W., Francis B. J. Foodborne disease surveillance: Washington State. Am J Public Health. 1974 Sep;64(9):854–859. doi: 10.2105/ajph.64.9.854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bergeland M. E. Pathogenesis and immunity of Clostridium perfringens type C enteritis in swine. J Am Vet Med Assoc. 1972 Feb 15;160(4):568–571. [PubMed] [Google Scholar]
  8. Buxton D. Further studies on the mode of action of Clostridium welchii type-D epsilon toxin. J Med Microbiol. 1978 Aug;11(3):293–298. doi: 10.1099/00222615-11-3-293. [DOI] [PubMed] [Google Scholar]
  9. Buxton D. The use of an immunoperoxidase technique to investigate by light and electron microscopy the sites of binding of Clostridium welchii type-D epsilon toxin in mice. J Med Microbiol. 1978 Aug;11(3):289–292. doi: 10.1099/00222615-11-3-289. [DOI] [PubMed] [Google Scholar]
  10. Dickie C. W., Klinkerman D. L., Petrie R. J. Enterotoxemia in two foals. J Am Vet Med Assoc. 1978 Aug 1;173(3):306–307. [PubMed] [Google Scholar]
  11. Duncan C. L., Strong D. H. Experimental production of diarrhea in rabbits with Clostridium perfringens. Can J Microbiol. 1969 Jul;15(7):765–770. doi: 10.1139/m69-134. [DOI] [PubMed] [Google Scholar]
  12. Duncan C. L., Strong D. H. Ileal loop fluid accumulation and production of diarrhea in rabbits by cell-free products of Clostridium perfringens. J Bacteriol. 1969 Oct;100(1):86–94. doi: 10.1128/jb.100.1.86-94.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. ELLNER P. D. Fate of partially purified C-14-labeled toxin of Clostridium perfringens. J Bacteriol. 1961 Aug;82:275–283. doi: 10.1128/jb.82.2.275-283.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. FIELD H. I., GOODWIN R. F. The experimental reproduction of enterotoxaemia in piglets. J Hyg (Lond) 1959 Mar;57(1):81–91. doi: 10.1017/s0022172400019914. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. GRINER L. A., BRACKEN F. K. Clostridium perfringens (type C) in acute hemorrhagic enteritis of calves. J Am Vet Med Assoc. 1953 Feb;122(911):99–102. [PubMed] [Google Scholar]
  16. GRINER L. A., JOHNSON H. W. Clostridium perfringens type C in hemorrhagic enterotoxemia of lambs. J Am Vet Med Assoc. 1954 Aug;125(929):125–127. [PubMed] [Google Scholar]
  17. Gardner D. E. Pathology of Clostridium welchii type D enterotoxaemia. I. Biochemical and haematological alterations in lambs. J Comp Pathol. 1973 Oct;83(4):499–507. doi: 10.1016/0021-9975(73)90008-x. [DOI] [PubMed] [Google Scholar]
  18. Gardner D. E. Pathology of Clostridium welchii type D enterotoxaemia. II. Structural and ultrastructural alterations in the tissues of lambs and mice. J Comp Pathol. 1973 Oct;83(4):509–524. doi: 10.1016/0021-9975(73)90009-1. [DOI] [PubMed] [Google Scholar]
  19. Genigeorgis C. Public health importance of Clostridium perfringens. J Am Vet Med Assoc. 1975 Nov 1;167(9):821–827. [PubMed] [Google Scholar]
  20. Hauschild A. H., Hilsheimer R. Purification and characteristics of the enterotoxin of Clostridium perfringens type A. Can J Microbiol. 1971 Nov;17(11):1425–1433. doi: 10.1139/m71-227. [DOI] [PubMed] [Google Scholar]
  21. Hauschild A. H., Niilo L., Dorward W. J. Clostridium perfringens type A infection of ligated intestinal loops in lambs. Appl Microbiol. 1968 Aug;16(8):1235–1239. doi: 10.1128/am.16.8.1235-1239.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Hauschild A. H., Thatcher F. S. Experimental gas gangrene with food-poisoning Clostridium perfringens type A. Can J Microbiol. 1968 Jun;14(6):705–709. doi: 10.1139/m68-117. [DOI] [PubMed] [Google Scholar]
  23. Jasmin A. M., Cooperrider D. E., Powell C. P., Baucom J. N. Enterotoxemia of wildfowl due to Cl. perfringens type C. J Wildl Dis. 1972 Jan;8(1):79–84. doi: 10.7589/0090-3558-8.1.79. [DOI] [PubMed] [Google Scholar]
  24. Kennedy K. K., Norris S. J., Beckenhauer W. H., Hogg A. Vaccination of pregnant sows with Clostridium perfringens type C toxoid. Vet Med Small Anim Clin. 1977 Jun;72(6):1047–1049. [PubMed] [Google Scholar]
  25. Kennedy K. K., Norris S. J., Beckenhauer W. H., White R. G. Antitoxin response in cattle vaccinated with Clostridium perfringens type C toxoid. Vet Med Small Anim Clin. 1977 Jul;72(7):1213–1215. [PubMed] [Google Scholar]
  26. Kennedy K. K., Norris S. J., Beckenhauer W. H., White R. G. Vaccination of cattle and sheep with a combined Clostridium perfringens types C and D toxoid. Am J Vet Res. 1977 Oct;38(10):1515–1517. [PubMed] [Google Scholar]
  27. Loewenstein M. S. Epidemiology of Clostridium perfringens food poisoning. N Engl J Med. 1972 May 11;286(19):1026–1028. doi: 10.1056/NEJM197205112861903. [DOI] [PubMed] [Google Scholar]
  28. Long J. R., Truscott R. B. Necrotic enteritis in broiler chickens. III. Reproduction of the disease. Can J Comp Med. 1976 Jan;40(1):53–59. [PMC free article] [PubMed] [Google Scholar]
  29. Lozano E. A., Catlin J. E., Hawkins W. W. Incidence of Clostridium perfringens in neonatal enteritis of Montana calves. Cornell Vet. 1970 Jul;60(3):347–359. [PubMed] [Google Scholar]
  30. MACLENNAN J. D. The histotoxic clostridial infections of man. Bacteriol Rev. 1962 Jun;26:177–276. [PMC free article] [PubMed] [Google Scholar]
  31. Möllby R., Holme T., Nord C. E., Smyth C. J., Wadström T. Production of phospholipase C (alpha-toxin), haemolysins and lethal toxins by Clostridium perfringens types A to D. J Gen Microbiol. 1976 Sep;96(1):137–144. doi: 10.1099/00221287-96-1-137. [DOI] [PubMed] [Google Scholar]
  32. NIILO L. BOVINE "ENTEROTOXEMIA". 3. FACTORS AFFECTING THE STABILITY OF THE TOXINS OF CLOSTRIDIUM PERFRINGENS TYPES A, C AND D. Can Vet J. 1965 Feb;6(2):38–42. [PMC free article] [PubMed] [Google Scholar]
  33. Niilo L., Avery R. J. Bovine "Enterotoxemia" I. Clostridium Perfringens Types Isolated from Animal Sources in Alberta and Saskatchewan. Can Vet J. 1963 Feb;4(2):31–36. [PMC free article] [PubMed] [Google Scholar]
  34. Niilo L., Dorward W. J. The effect of enterotoxigenic Clostridium welchii (perfringens) type A on the bovine intestine. Res Vet Sci. 1971 Jul;12(4):376–378. [PubMed] [Google Scholar]
  35. Niilo L. Effect on calves of the intravenous injection of the enterotoxin of Clostridium welchii type A. J Comp Pathol. 1973 Apr;83(2):265–269. doi: 10.1016/0021-9975(73)90051-0. [DOI] [PubMed] [Google Scholar]
  36. Niilo L. Enterotoxigenic Clostridium perfringens type A isolated from intestinal contents of cattle, sheep and chickens. Can J Comp Med. 1978 Jul;42(3):357–363. [PMC free article] [PubMed] [Google Scholar]
  37. Niilo L. Enterotoxin formation by Clostridium perfringens type A studied by the use of fluorescent antibody. Can J Microbiol. 1977 Jul;23(7):908–915. doi: 10.1139/m77-134. [DOI] [PubMed] [Google Scholar]
  38. Niilo L. Fluid secretory response of bovine Thiry jejunal fistula to enterotoxin of Clostridium perfringens. Infect Immun. 1973 Jan;7(1):1–4. doi: 10.1128/iai.7.1.1-4.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Niilo L., Harries W. N., Jones G. A. Clostridium perfringens type C in hemorrhagic enterotoxemia of neonatal calves in Alberta. Can Vet J. 1974 Aug;15(8):224–226. [PMC free article] [PubMed] [Google Scholar]
  40. Niilo L., Hauschild A. H., Dorward W. J. Immunization of sheep against experimental Clostridium perfringens type A enteritis. Can J Microbiol. 1971 Mar;17(3):391–395. doi: 10.1139/m71-065. [DOI] [PubMed] [Google Scholar]
  41. Niilo L. Mechanism of Action of the Enteropathogenic Factor of Clostridium perfringens Type A. Infect Immun. 1971 Jan;3(1):100–106. doi: 10.1128/iai.3.1.100-106.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Niilo L., Moffatt R. E., Avery R. J. Bovine "Enterotoxemia". II. Experimental Reproduction of the Disease. Can Vet J. 1963 Nov;4(11):288–298. [PMC free article] [PubMed] [Google Scholar]
  43. Niilo L. Response of ligated intestinal loops in chickens to the enterotoxin of Clostridium perfringens. Appl Microbiol. 1974 Nov;28(5):889–891. doi: 10.1128/am.28.5.889-891.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Niilo L. The effect of enterotoxin of Clostridium welchii (perfringens) on the systemic blood pressure of sheep. Res Vet Sci. 1972 Sep;13(5):503–505. [PubMed] [Google Scholar]
  45. Niilo L. The effect of enterotoxin of Clostridium welchii (perfringens) type A on fowls. Res Vet Sci. 1976 Mar;20(2):225–226. [PubMed] [Google Scholar]
  46. PARISH W. E. Necrotic enteritis in the fowl. II. Examination of the causal Clostridium welchii. J Comp Pathol. 1961 Oct;71:394–404. doi: 10.1016/s0368-1742(61)80044-1. [DOI] [PubMed] [Google Scholar]
  47. Patton N. M., Holmes H. T., Riggs R. J., Cheeke P. R. Enterotoxemia in rabbits. Lab Anim Sci. 1978 Oct;28(5):536–540. [PubMed] [Google Scholar]
  48. STERNE M., WARRACK G. H. THE TYPES OF CLOSTRIDIUM PERFRINGENS. J Pathol Bacteriol. 1964 Jul;88:279–283. [PubMed] [Google Scholar]
  49. Sakurai J., Duncan C. L. Purification of beta-toxin from Clostridium perfringens type C. Infect Immun. 1977 Dec;18(3):741–745. doi: 10.1128/iai.18.3.741-745.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Sakurai J., Duncan C. L. Some properties of beta-toxin produced by Clostridium perfringens type C. Infect Immun. 1978 Aug;21(2):678–680. doi: 10.1128/iai.21.2.678-680.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Skjelkvålé R., Duncan C. L. Enterotoxin formation by different toxigenic types of Clostridium perfringens. Infect Immun. 1975 Mar;11(3):563–575. doi: 10.1128/iai.11.3.563-575.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Smith L. D. Virulence factors of Clostridium perfringens. Rev Infect Dis. 1979 Mar-Apr;1(2):254–262. doi: 10.1093/clinids/1.2.254. [DOI] [PubMed] [Google Scholar]
  53. Stark R. L., Duncan C. L. Purification and biochemical properties of Clostridium perfringens type A enterotoxin. Infect Immun. 1972 Nov;6(5):662–673. doi: 10.1128/iai.6.5.662-673.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Sutton R. G., Hobbs B. C. Food poisoning caused by heat-sensitive Clostridium welchii. A report of five recent outbreaks. J Hyg (Lond) 1968 Mar;66(1):135–146. doi: 10.1017/s0022172400041000. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Tsai C. C., Torres-Anjel M. J., Riemann H. P. Characteristics of enterotoxigenic Clostridium perfringens type A isolated from cattle and chickens. Taiwan Yi Xue Hui Za Zhi. 1974 Sep;73(9):501–510. [PubMed] [Google Scholar]
  56. Vance H. N. A survey of the alimentary tract of cattle for Clostridium perfringens. Can J Comp Med Vet Sci. 1967 Oct;31(10):260–264. [PMC free article] [PubMed] [Google Scholar]
  57. Vance H. N. Clostridium perfringens as a pathogen of cattle: a literature review. Can J Comp Med Vet Sci. 1967 Oct;31(10):248–250. [PMC free article] [PubMed] [Google Scholar]

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