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. 1981 Mar;22(3):51–58.

La diarrhée néonatale due au coronavirus de veau. Une revue de la littérature

S Dea, R S Roy, M A S Y Elazhary
PMCID: PMC1789880  PMID: 6269715

Abstract

Calf coronavirus neonatal diarrhea. A literature review

The importance of the calf coronavirus in the etiology of neonatal diarrhea of calves has been reported many times from various countries. A literature review concerning this virus is presented in this paper. A detailed description of the pathogenesis, clinical signs and lesions of the disease, as well as the morphological, physicochemical, biological and antigenic characteristics of the virus are presented. The immunity of the calf against this virus and the principal diagnosis technics are also discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acres S. D., Laing C. J., Saunders J. R., Radostits O. M. Acute undifferentiated neonatal diarrhea in beef calves. I. Occurence and distribution of infectious agents. Can J Comp Med. 1975 Apr;39(2):116–132. [PMC free article] [PubMed] [Google Scholar]
  2. Alexander D. J., Collins M. S. Effect of pH on the growth and cytopathogenicity of avian infectious bronchitis virus in chick kidney cells. Arch Virol. 1975;49(4):339–348. doi: 10.1007/BF01318243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Almeida J. D., Craig C. R., Hall T. E. Multiple viruses present in the faeces of a scouring calf. Vet Rec. 1978 Feb 25;102(8):170–171. doi: 10.1136/vr.102.8.170. [DOI] [PubMed] [Google Scholar]
  4. BAKER J. A., McENTEE K., GILLESPIE J. H. Effects of infectious bovine rhinotracheitis-infectious pustular vulvovaginitis (IBR-IPV) virus on newborn calves. Cornell Vet. 1960 Apr;50:156–170. [PubMed] [Google Scholar]
  5. Bohac J., Derbyshire J. B. The demonstration of transmissible gastroenteritis viral antigens by immunoelectrophoresis and counterimmunoelectrophoresis. Can J Microbiol. 1975 Jun;21(6):750–753. doi: 10.1139/m75-111. [DOI] [PubMed] [Google Scholar]
  6. Bridger J. C., Caul E. O., Egglestone S. I. Replication of an enteric bovine coronavirus in intestinal organ cultures. Arch Virol. 1978;57(1):43–51. doi: 10.1007/BF01315636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Cagienard B. Some observations on disease incidence among dairy cattle in North Taranaki. N Z Vet J. 1973 Aug;21(8):170–174. doi: 10.1080/00480169.1973.34099. [DOI] [PubMed] [Google Scholar]
  8. Chasey D., Lucas M. A bovine coronavirus identified by thin-section electron microscopy. Vet Rec. 1977 Jun 18;100(25):530–531. doi: 10.1136/vr.100.25.530. [DOI] [PubMed] [Google Scholar]
  9. Dea S., Roy R. S., Begin M. E. Bovine coronavirus isolation and cultivation in continuous cell lines. Am J Vet Res. 1980 Jan;41(1):30–38. [PubMed] [Google Scholar]
  10. Dea S., Roy R. S., Begin M. E. Counterimmunoelectroosmophoresis for detection of neonatal calf diarrhea coronavirus: methodology and comparison with electron microscopy. J Clin Microbiol. 1979 Aug;10(2):240–244. doi: 10.1128/jcm.10.2.240-244.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Dea S., Roy R. S., Begin M. E. Physicochemical and biological properties of neonatal calf diarrhea coronaviruses isolated in Quebec and comparison with the Nebraska calf coronavirus. Am J Vet Res. 1980 Jan;41(1):23–29. [PubMed] [Google Scholar]
  12. Doane F. W., Anderson N., Zbitnew A., Rhodes A. J. Application of electron microscopy to the diagnosis of virus infections. Can Med Assoc J. 1969 Jun 14;100(22):1043–1049. [PMC free article] [PubMed] [Google Scholar]
  13. Doughri A. M., Storz J., Hajer I., Fernando H. S. Morphology and morphogenesis of a coronavirus infecting intestinal epithelial cells of newborn calves. Exp Mol Pathol. 1976 Dec;25(3):355–370. doi: 10.1016/0014-4800(76)90045-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Doughri A. M., Storz J. Light and ultrastructural pathologic changes in intestinal coronavirus infection of newborn calves. Zentralbl Veterinarmed B. 1977;24(5):367–385. doi: 10.1111/j.1439-0450.1977.tb01011.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Doughri A. M., Yong S., Storz J. Pathologic changes in intestinal chlamydial infection of newborn calves. Am J Vet Res. 1974 Jul;35(7):939–944. [PubMed] [Google Scholar]
  16. England J. J., Frye C. S., Enright E. A. Negative contrast electron microscopic diagnosis of viruses of neonatal calf diarrhea. Cornell Vet. 1976 Apr;66(2):172–182. [PubMed] [Google Scholar]
  17. Garwes D. J., Pocock D. H. The polypeptide structure of transmissible gastroenteritis virus. J Gen Virol. 1975 Oct;29(1):25–34. doi: 10.1099/0022-1317-29-1-25. [DOI] [PubMed] [Google Scholar]
  18. Garwes D. J., Pocock D. H., Wijaszka T. M. Identification of heat-dissociable RNA complexes in two porcine coronaviruses. Nature. 1975 Oct 9;257(5526):508–510. doi: 10.1038/257508a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Guy J. S., Brian D. A. Bovine coronavirus genome. J Virol. 1979 Jan;29(1):293–300. doi: 10.1128/jvi.29.1.293-300.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Hajer I., Storz J. Antigens of bovine coronavirus strain LY-138 and their diagnostic properties. Am J Vet Res. 1978 Mar;39(3):441–444. [PubMed] [Google Scholar]
  21. Hajer I., Storz J. Structural polypeptides of the enteropathogenic bovine coronavirus strain LY-138. Arch Virol. 1979;59(1-2):47–57. doi: 10.1007/BF01317894. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Harada K., Kaji T., Kumagai T., Sasahara J. Studies on transmissible gastroenteritis in pigs. IV. Physicochemical and biological properties of TGE virus. Natl Inst Anim Health Q (Tokyo) 1968 Fall;8(3):140–147. [PubMed] [Google Scholar]
  23. Hierholzer J. C., Palmer E. L., Whitfield S. G., Kaye H. S., Dowdle W. R. Protein composition of coronavirus OC 43. Virology. 1972 May;48(2):516–527. doi: 10.1016/0042-6822(72)90062-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Hierholzer J. C. Purification and biophysical properties of human coronavirus 229E. Virology. 1976 Nov;75(1):155–165. doi: 10.1016/0042-6822(76)90014-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Hooper B. E., Haelterman E. O. Lesions of the gastrointestinal tract of pigs infected with transmissible gastroenteritis. Can J Comp Med. 1969 Jan;33(1):29–36. [PMC free article] [PubMed] [Google Scholar]
  26. Horner G. W., Hunter R., Kirkbride C. A. Letter: A coronavirus-like agent present in faeces of cows with diarrhoea. N Z Vet J. 1975 May;23(5):98–98. doi: 10.1080/00480169.1975.34206. [DOI] [PubMed] [Google Scholar]
  27. House J. A. Economic impact of rotavirus and other neonatal disease agents of animals. J Am Vet Med Assoc. 1978 Sep 1;173(5 Pt 2):573–576. [PubMed] [Google Scholar]
  28. Inaba Y., Sato K., Kurogi H., Takahashi E., Ito Y. Replication of bovine coronavirus in cell line BEK-1 culture. Arch Virol. 1976;50(4):339–342. doi: 10.1007/BF01317959. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Kapikian A. Z. The coronaviruses. Dev Biol Stand. 1975;28:42–64. [PubMed] [Google Scholar]
  30. Lai M. M., Stohlman S. A. RNA of mouse hepatitis virus. J Virol. 1978 May;26(2):236–242. doi: 10.1128/jvi.26.2.236-242.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Lambert G., Fernelius A. L. Bovine viral diarrhea virus and Escherichia coli in neonatal calf enteritis. Can J Comp Med. 1968 Apr;32(2):440–446. [PMC free article] [PubMed] [Google Scholar]
  32. Lambert G., McClurkin A. W., Fernelius A. L. Bovine viral diarrhea in the neonatal calf. J Am Vet Med Assoc. 1974 Feb 1;164(3):287–289. [PubMed] [Google Scholar]
  33. Langpap T. J., Bergeland M. E., Reed D. E. Coronaviral enteritis of young calves: virologic and pathologic findings in naturally occurring infections. Am J Vet Res. 1979 Oct;40(10):1476–1478. [PubMed] [Google Scholar]
  34. Laporte J., Bobulesco P., Rossi F. Une lignée cellulaire particulièrement sensible à la réplication du Coronavirus entéritique bovin : les cellules HRT 18. C R Seances Acad Sci D. 1980 Mar 3;290(9):623–626. [PubMed] [Google Scholar]
  35. Les E. P. Environmental factors influencing body weight of C57BL-6J and DBA-2 J mice. Lab Anim Care. 1968 Dec;18(6):623–625. [PubMed] [Google Scholar]
  36. Lewis L. D., Phillips R. W. Pathophysiologic changes due to coronavirus-induced diarrhea in the calf. J Am Vet Med Assoc. 1978 Sep 1;173(5 Pt 2):636–642. [PubMed] [Google Scholar]
  37. Lomniczi B., Kennedy I. Genome of infectious bronchitis virus. J Virol. 1977 Oct;24(1):99–107. doi: 10.1128/jvi.24.1.99-107.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Macnaughton M. R., Madge M. H., Davies H. A., Dourmashkin R. R. Polypeptides of the surface projections and the ribonucleoprotein of avian infectious bronchitis virus. J Virol. 1977 Dec;24(3):821–825. doi: 10.1128/jvi.24.3.821-825.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Marsolais G., Assaf R., Montpetit C., Marois P. Diagnosis of viral agents associated with neonatal calf diarrhea. Can J Comp Med. 1978 Apr;42(2):168–171. [PMC free article] [PubMed] [Google Scholar]
  40. Mattson D. E. Naturally occurring infection of calves with a bovine adenovirus. Am J Vet Res. 1973 May;34(5):623–629. [PubMed] [Google Scholar]
  41. Mebus C. A., Newman L. E., Stair E. L., Jr Scanning electron, light, and immunofluorescent microscopy of intestine of gnotobiotic calf infected with calf diarrheal coronavirus. Am J Vet Res. 1975 Dec;36(12):1719–1725. [PubMed] [Google Scholar]
  42. Mebus C. A., Stair E. L., Rhodes M. B., Twiehaus M. J. Neonatal calf diarrhea: propagation, attenuation, and characteristics of a coronavirus-like agent. Am J Vet Res. 1973 Feb;34(2):145–150. [PubMed] [Google Scholar]
  43. Mebus C. A., Stair E. L., Rhodes M. B., Twiehaus M. J. Pathology of neonatal calf diarrhea induced by a coronavirus-like agent. Vet Pathol. 1973;10(1):45–64. doi: 10.1177/030098587301000105. [DOI] [PubMed] [Google Scholar]
  44. Mebus C. A., White R. G., Stair E. L., Rhodes M. B., Twiehaus M. J. Neonatal calf diarrhea: results of a field trial using a reo-like virus vaccine. Vet Med Small Anim Clin. 1972 Feb;67(2):173–passim. [PubMed] [Google Scholar]
  45. Melbus C. A. Calf diaarhea induced by coronavirus and a reovirus-like agent. Mod Vet Pract. 1976 Sep;57(9):693–698. [PubMed] [Google Scholar]
  46. Mengeling W. L., Boothe A. D., Ritchie A. E. Characteristics of a coronavirus (strain 67N) of pigs. Am J Vet Res. 1972 Feb;33(2):297–308. [PubMed] [Google Scholar]
  47. Mengeling W. L. Precipitating antigens of hemagglutinating encephalomyelitis virus demonstrated by agar gel immunodiffusion. Am J Vet Res. 1972 Jul;33(7):1527–1535. [PubMed] [Google Scholar]
  48. Meuten D. J., Van Kruiningen H. J., Lein D. H. Cryptosporidiosis in a calf. J Am Vet Med Assoc. 1974 Nov 15;165(10):914–917. [PubMed] [Google Scholar]
  49. Moon H. W., McClurkin A. W., Isaacson R. E., Pohlenz J., Skartvedt S. M., Gillette K. G., Baetz A. L. Pathogenic relationships of rotavirus, Escherichia coli, and other agents in mixed infections in calves. J Am Vet Med Assoc. 1978 Sep 1;173(5 Pt 2):577–583. [PubMed] [Google Scholar]
  50. Morin M., Lamothe P., Gagnon A., Malo R. A case of viral neonatal calf diarrhea in a Quebec dairy herd. Can J Comp Med. 1974 Jul;38(3):236–242. [PMC free article] [PubMed] [Google Scholar]
  51. Morin M., Larivière S., Lallier R. Pathological and microbiological observations made on spontaneous cases of acute neonatal calf diarrhea. Can J Comp Med. 1976 Jul;40(3):228–240. [PMC free article] [PubMed] [Google Scholar]
  52. Nagy E., Lomniczi B. Polypeptide patterns of infectious bronchitis virus serotypes fall into two categories. Brief report. Arch Virol. 1979;61(4):341–345. doi: 10.1007/BF01315022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Oxender W. D., Newman L. E., Morrow D. A. Factors influencing dairy calf mortality in Michigan. J Am Vet Med Assoc. 1973 Mar 15;162(6):458–460. [PubMed] [Google Scholar]
  54. Pensaert M., Haelterman E. O., Burnstein T. Transmissible gastroenteritis of swine: virus-intestinal cell interactions. I. Immunofluorescence, histopathology and virus production in the small intestine through the course of infection. Arch Gesamte Virusforsch. 1970;31(3):321–334. doi: 10.1007/BF01253767. [DOI] [PubMed] [Google Scholar]
  55. Reed D. E., Bicknell E. J., Bury R. J. Systemic form of infectious bovine rhinotracheitis in young calves. J Am Vet Med Assoc. 1973 Oct 1;163(7):753–755. [PubMed] [Google Scholar]
  56. Scherrer R., Cohen J., L'Haridon R., Feynerol C., Fayet J. C. Reovirus-like agent (rotavirus) associated with neonatal calf gastroenteritis in France. Ann Rech Vet. 1976;7(1):25–31. [PubMed] [Google Scholar]
  57. Schochetman G., Stevens R. H., Simpson R. W. Presence of infectious polyadenylated RNA in coronavirus avian bronchitis virus. Virology. 1977 Apr;77(2):772–782. doi: 10.1016/0042-6822(77)90498-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Sharpee R. L., Mebus C. A., Bass E. P. Characterization of a calf diarrheal coronavirus. Am J Vet Res. 1976 Sep;37(9):1031–1041. [PubMed] [Google Scholar]
  59. Stair E. L., Mebus C. A., Twiehaus M. J., Underdahl N. R. Neonatal calf diarrhea. Electron microscopy of intestines infected with a reovirus-like agent. Vet Pathol. 1973;10(2):155–170. doi: 10.1177/030098587301000208. [DOI] [PubMed] [Google Scholar]
  60. Stair E. L., Rhodes M. B., White R. G., Mebus C. A. Neonatal calf diarrhea: purification and electron microscopy of a coronavirus-like agent. Am J Vet Res. 1972 Jun;33(6):1147–1156. [PubMed] [Google Scholar]
  61. Storz J., Eugster A. K., Altera K. P., Olander H. J. Behavior of different bovine chlamydial agents in newborn calves. J Comp Pathol. 1971 Apr;81(2):299–307. doi: 10.1016/0021-9975(71)90104-6. [DOI] [PubMed] [Google Scholar]
  62. Storz J., Leary J. J., Carlson J. H., Bates R. C. Parvoviruses associated with diarrhea in calves. J Am Vet Med Assoc. 1978 Sep 1;173(5 Pt 2):624–627. [PubMed] [Google Scholar]
  63. Sturman L. S. I. Structural proteins: effects of preparative conditions on the migration of protein in polyacrylamide gels. Virology. 1977 Apr;77(2):637–649. doi: 10.1016/0042-6822(77)90488-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Tannock G. A., Hierholzer The RNA of human coronavirus OC-43. Virology. 1977 May 15;78(2):500–510. doi: 10.1016/0042-6822(77)90126-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Tevethia S. S., Cunningham C. H. Antigenic characterization of infectious bronchitis virus. J Immunol. 1968 Apr;100(4):793–798. [PubMed] [Google Scholar]
  66. Thurber E. T., Bass E. P., Beckenhauer W. H. Field trial evaluation of a reo-coronavirus calf diarrhea vaccine. Can J Comp Med. 1977 Apr;41(2):131–136. [PMC free article] [PubMed] [Google Scholar]
  67. Thyroid function after treatment of hyperthyroidism. Lancet. 1975 Sep 27;2(7935):590–591. [PubMed] [Google Scholar]
  68. Waldhalm D. G., Meinershagen W. A., Frank F. W. Providencia stuartii as an etiologic agent in neonatal diarrhea in calves. Am J Vet Res. 1969 Sep;30(9):1573–1575. [PubMed] [Google Scholar]
  69. Welch A. B. Purification, morphology and partial characterization of a reovirus-like agent associated with neonatal calf diarrhea. Can J Comp Med. 1971 Jul;35(3):195–202. [PMC free article] [PubMed] [Google Scholar]
  70. White R. G., Mebus C. A., Twiehaus M. J. Incidence of herds infected with a neonatal calf diarrhea virus (NCDV). Vet Med Small Anim Clin. 1970 May;65(5):487–490. [PubMed] [Google Scholar]
  71. Woode G. N., Bridger J. C. Isolation of small viruses resembling astroviruses and caliciviruses from acute enteritis of calves. J Med Microbiol. 1978 Nov;11(4):441–452. doi: 10.1099/00222615-11-4-441. [DOI] [PubMed] [Google Scholar]
  72. Woode G. N., Bridger J. C., Meyling A. Significance of bovine coronavirus infection. Vet Rec. 1978 Jan 7;102(1):15–16. doi: 10.1136/vr.102.1.15. [DOI] [PubMed] [Google Scholar]

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