Abstract
Three antibiotic formulations, oxytetracycline (A) in propylene glycol and oxytetracycline (B) in polyvinyl pyrrolidine and pyrrolidino-methyltetracycline in an oil suspension were given to calves by the intramuscular route. Only oxytetracycline (A) appeared to cause much pain after injection.
The half-time elimination (t½cl) for oxytetracycline (A) was 14.000 ± 3.580 h for oxytetracycline (B) 10.290 ±5.159 h and for pyrrolidinomethyltetracycline 8.160 ± 0.920 h. The rate of elimination `beta slope” for oxytetracycline (A) was 0.052 ± 0.012 h−1 for oxytetracycline (B) 0.077 ± 0.261 h−1 and for pyrrolidinomethyltetracycline 0.086 ± 0.010 h−1. The Y intercept of the “beta” elimination slope Cos (μg/mL) for oxytetracycline (A) was 2.490 ± 1.040, for oxytetracycline (B) 3.463 ± 1.874 and for pyrrolidinomethyltetracycline 2.852 ± 1.360.
Pyrrolidinomethyltetracycline appeared to have a two component elimination curve, however, only the “beta slope” was used for the calculations.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arret B., Johnson D. P., Kirshbaum A. Outline of details for microbiological assays of antibiotics: second revision. J Pharm Sci. 1971 Nov;60(11):1689–1694. doi: 10.1002/jps.2600601122. [DOI] [PubMed] [Google Scholar]
- Pilloud M. Pharmacokinetics, plasma protein binding and dosage of oxytetracycline in cattle and horses. Res Vet Sci. 1973 Sep;15(2):224–230. [PubMed] [Google Scholar]
- YODER H. W., Jr, PACKER R. A. Bovine blood serum concentrations of terramycin (Oxytetracycline) following intravenous and intramuscular administration. Am J Vet Res. 1954 Jul;15(56):412–416. [PubMed] [Google Scholar]
- Ziv G., Sulman F. G. Analysis of pharmacokinetic properties of nine tetracycline analogues in dairy cows and ewes. Am J Vet Res. 1974 Sep;35(9):1197–1201. [PubMed] [Google Scholar]