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. 1983 Aug;24(8):239–242.

Effects of Prostaglandin F2α on Corpora Lutea Formation and Function in Mated Bitches

M Paradis, K Post, R J Mapletoft
PMCID: PMC1790389  PMID: 17422289

Abstract

Fifteen mated bitches were used to study the effects of prostaglandin F2α on ovarian endocrine function during the early and midluteal phase. Five dogs were kept as controls, five were given 250 μg/kg prostaglandin F2α twice daily between the first and fifth day of metestrus, and five were similarly treated with prostaglandin F2α between 31 and 35 days of metestrus. Function of corpora lutea was monitored by measuring serum progesterone concentrations during the first 45 days of gestation.

Dogs treated with prostaglandin F2α during the early luteal phase had progesterone concentrations similar to controls and pregnancies were undisturbed in both groups. A dramatic decrease in serum progesterone concentration and abortion resulted after prostaglandin F2α administration at midpregnancy.

These results indicate that prostaglandin F2α was not luteolytic during the early luteal phase and was therefore ineffective for preventing pregnancy at that time. However, at the dosage and frequency used in this study, prostaglandin F2α was luteolytic and abortifacient at midgestation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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