Abstract
Seventeen biopsies of feline mammary carcinoma submitted to the Veterinary Pathology Laboratory, Nova Scotia Department of Agriculture and Marketing were reviewed. All 17 cases were female cats. Data on age, reproductive status (sexually intact vs. neutered), therapy, outcome of the cases and histological features were consistent with data on feline mammary carcinoma previously reported. Four of these 17 cats had a history of receiving exogenous progestin prior to tumor development. The possible role of progestins as initiators or promoters of feline mammary carcinoma was discussed. The use of feline mammary carcinoma as a model for carcinoma of the breast in women was reviewed.
Keywords: Feline, mammary gland, neoplasia, carcinoma, animal model
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Clark G. M., McGuire W. L., Hubay C. A., Pearson O. H., Marshall J. S. Progesterone receptors as a prognostic factor in Stage II breast cancer. N Engl J Med. 1983 Dec 1;309(22):1343–1347. doi: 10.1056/nejm198312013092240. [DOI] [PubMed] [Google Scholar]
- Dorn C. R., Taylor D. O., Frye F. L., Hibbard H. H. Survey of animal neoplasms in Alameda and Contra Costa Counties, California. I. Methodology and description of cases. J Natl Cancer Inst. 1968 Feb;40(2):295–305. [PubMed] [Google Scholar]
- Dorn C. R., Taylor D. O., Schneider R., Hibbard H. H., Klauber M. R. Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. J Natl Cancer Inst. 1968 Feb;40(2):307–318. [PubMed] [Google Scholar]
- Elling H., Ungemach F. R. Progesterone receptors in feline mammary cancer cytosol. J Cancer Res Clin Oncol. 1981;100(3):325–327. doi: 10.1007/BF00410693. [DOI] [PubMed] [Google Scholar]
- Frantz A. G. Prolactin. N Engl J Med. 1978 Jan 26;298(4):201–207. doi: 10.1056/NEJM197801262980408. [DOI] [PubMed] [Google Scholar]
- Hamilton J. M., Else R. W., Forshaw P. Oestrogen receptors in feline mammary carcinomas. Vet Rec. 1976 Dec 11;99(24):477–479. doi: 10.1136/vr.99.24.477. [DOI] [PubMed] [Google Scholar]
- Hampe J. F., Misdorp W. Tumours and dysplasias of the mammary gland. Bull World Health Organ. 1974;50(1-2):111–133. [PMC free article] [PubMed] [Google Scholar]
- Hayden D. W., Johnston S. D., Kiang D. T., Johnson K. H., Barnes D. M. Feline mammary hypertrophy/fibroadenoma complex: clinical and hormonal aspects. Am J Vet Res. 1981 Oct;42(10):1699–1703. [PubMed] [Google Scholar]
- Hayes A. Feline mammary gland tumors. Vet Clin North Am. 1977 Feb;7(1):205–212. doi: 10.1016/s0091-0279(77)50017-2. [DOI] [PubMed] [Google Scholar]
- Hayes H. M., Jr, Milne K. L., Mandell C. P. Epidemiological features of feline mammary carcinoma. Vet Rec. 1981 May 30;108(22):476–479. doi: 10.1136/vr.108.22.476. [DOI] [PubMed] [Google Scholar]
- Hernandez F. J., Fernandez B. B., Chertack M., Gage P. A. Feline mammary carcinoma and progestogens. Feline Pract. 1975 Sep-Oct;5(5):45–48. [PubMed] [Google Scholar]
- Jabara A. G., Harcourt A. G. The effects of progesterone and ovariectomy on mammary tumours induced by 7,1 2-dimethylbenz(a)anthracene in Sprague-Dawley rats. Pathology. 1970 Apr;2(2):115–123. doi: 10.3109/00313027009077333. [DOI] [PubMed] [Google Scholar]
- Johnston S. D., Hayden D. W., Kiang D. T., Handschin B., Johnson K. H. Progesterone receptors in feline mammary adenocarcinomas. Am J Vet Res. 1984 Feb;45(2):379–382. [PubMed] [Google Scholar]
- Knight C. H., Peaker M. Development of the mammary gland. J Reprod Fertil. 1982 Jul;65(2):521–536. doi: 10.1530/jrf.0.0650521. [DOI] [PubMed] [Google Scholar]
- Kwapien R. P., Giles R. C., Geil R. G., Casey H. W. Malignant mammary tumors in beagle dogs dosed with investigational oral contraceptive steroids. J Natl Cancer Inst. 1980 Jul;65(1):137–144. [PubMed] [Google Scholar]
- Misdorp W., Weijer K. Animal model of human disease: breast cancer. Am J Pathol. 1980 Feb;98(2):573–576. [PMC free article] [PubMed] [Google Scholar]
- Nelson L. W., Carlton W. W., Weikel J. H., Jr Canine mammary neoplasms and progestogens. JAMA. 1972 Mar 20;219(12):1601–1606. [PubMed] [Google Scholar]
- Oen E. O. The oral administration of megestrol acetate to postpone oestrus in cats. Nord Vet Med. 1977 Jun;29(6):287–291. [PubMed] [Google Scholar]
- Sarrif A. M., Durant J. R. Evidence that estrogen-receptor-negative, progesterone-receptor-positive breast and ovarian carcinomas contain estrogen receptor. Cancer. 1981 Sep 1;48(5):1215–1220. doi: 10.1002/1097-0142(19810901)48:5<1215::aid-cncr2820480527>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
- Weijer K., Calafat J., Daams J. H., Hageman P. C., Misdorp W. Feline malignant mammary tumors. II. Immunologic and electron microscopic investigations into a possible viral etiology. J Natl Cancer Inst. 1974 Mar;52(3):673–679. doi: 10.1093/jnci/52.3.673. [DOI] [PubMed] [Google Scholar]
- Weijer K., Hart A. A. Prognostic factors in feline mammary carcinoma. J Natl Cancer Inst. 1983 Apr;70(4):709–716. [PubMed] [Google Scholar]
- Weijer K., Head K. W., Misdorp W., Hampe J. F. Feline malignant mammary tumors. I. Morphology and biology: some comparisons with human and canine mammary carcinomas. J Natl Cancer Inst. 1972 Dec;49(6):1697–1704. doi: 10.1093/jnci/49.6.1697. [DOI] [PubMed] [Google Scholar]
- Weikel J. H., Jr, Nelson L. W. Problems in evaluating chronic toxicity of contraceptive steroids in dogs. J Toxicol Environ Health. 1977 Sep;3(1-2):167–177. doi: 10.1080/15287397709529556. [DOI] [PubMed] [Google Scholar]