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. 1989 May;64(5):693–696. doi: 10.1136/adc.64.5.693

Gall stones in Jamaican children with homozygous sickle cell disease.

D K Webb 1, J S Darby 1, D T Dunn 1, S I Terry 1, G R Serjeant 1
PMCID: PMC1792039  PMID: 2658854

Abstract

Gall stones were detected by ultrasonography in 30 of 226 (13%) children with homozygous sickle cell disease aged 5-13 years participating in a cohort study from birth. Children with gall stones had significantly lower total haemoglobin and fetal haemoglobin and higher bilirubin concentrations, but further analysis showed that the apparent effects of haemoglobin and fetal haemoglobin concentration were secondary to their relationship with bilirubin concentrations. Abdominal pain crises were significantly associated with gall stones but both factors appeared to reflect an increased clinical severity and were probably not causally related. No patients had symptoms specific of gall stones and an association with abdominal pain crisis should not, of itself, be considered an indication for surgery.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akamaguna A. I., Odita J. C., Ugbodaga C. I., Okafor L. A. Cholelithiasis in sickle cell disease: a cholecystographic and ultrasonographic evaluation in Nigerians. Eur J Radiol. 1985 Nov;5(4):271–272. [PubMed] [Google Scholar]
  2. Akinyanju O., Ladapo F. Cholelithiasis and biliary tract disease in sickle-cell disease in Nigerians. Postgrad Med J. 1979 Jun;55(644):400–402. doi: 10.1136/pgmj.55.644.400. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ariyan S., Shessel F. S., Pickett L. K. Cholecystitis and cholelithiasis masking as abdominal crises in sickle cell disease. Pediatrics. 1976 Aug;58(2):252–258. [PubMed] [Google Scholar]
  4. Bond L. R., Hatty S. R., Horn M. E., Dick M., Meire H. B., Bellingham A. J. Gall stones in sickle cell disease in the United Kingdom. Br Med J (Clin Res Ed) 1987 Jul 25;295(6592):234–236. doi: 10.1136/bmj.295.6592.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cunningham J. J., Houlihan S. M., Altay C. Cholecystosonography in children with sickle cell disease: technical approach and clinical results. J Clin Ultrasound. 1981 May-Jun;9(5):231–235. doi: 10.1002/jcu.1870090506. [DOI] [PubMed] [Google Scholar]
  6. Karayalcin G., Hassani N., Abrams M., Lanzkowsky P. Cholelithiasis in children with sickle cell disease. Am J Dis Child. 1979 Mar;133(3):306–307. doi: 10.1001/archpedi.1979.02130030082015. [DOI] [PubMed] [Google Scholar]
  7. Lachman B. S., Lazerson J., Starshak R. J., Vaughters F. M., Werlin S. L. The prevalence of cholelithiasis in sickle cell disease as diagnosed by ultrasound and cholecystography. Pediatrics. 1979 Nov;64(5):601–603. [PubMed] [Google Scholar]
  8. McCall I. W., Desai P., Serjeant B. E., Serjeant G. R. Cholelithiasis in Jamaican patients with homozygous sickle cell disease. Am J Hematol. 1977;3:15–21. doi: 10.1002/ajh.2830030102. [DOI] [PubMed] [Google Scholar]
  9. Perrine R. P. Cholelithiasis in sickle cell anemia in a Caucasian population. Am J Med. 1973 Mar;54(3):327–332. doi: 10.1016/0002-9343(73)90027-2. [DOI] [PubMed] [Google Scholar]
  10. Rennels M. B., Dunne M. G., Grossman N. J., Schwartz A. D. Cholelithiasis in patients with major sickle hemoglobinopathies. Am J Dis Child. 1984 Jan;138(1):66–67. doi: 10.1001/archpedi.1984.02140390054016. [DOI] [PubMed] [Google Scholar]
  11. Sarnaik S., Slovis T. L., Corbett D. P., Emami A., Whitten C. F. Incidence of cholelithiasis in sickle cell anemia using the ultrasonic gray-scale technique. J Pediatr. 1980 Jun;96(6):1005–1008. doi: 10.1016/s0022-3476(80)80626-3. [DOI] [PubMed] [Google Scholar]
  12. Serjeant B. E., Forbes M., Williams L. L., Serjeant G. R. Screening cord bloods for detection of sickle cell disease in Jamaica. Clin Chem. 1974 Jun;20(6):666–669. [PubMed] [Google Scholar]
  13. Serjeant G. R., Grandison Y., Lowrie Y., Mason K., Phillips J., Serjeant B. E., Vaidya S. The development of haematological changes in homozygous sickle cell disease: a cohort study from birth to 6 years. Br J Haematol. 1981 Aug;48(4):533–543. doi: 10.1111/j.1365-2141.1981.tb02750.x. [DOI] [PubMed] [Google Scholar]
  14. Serjeant G. R., Serjeant B. E., Forbes M., Hayes R. J., Higgs D. R., Lehmann H. Haemoglobin gene frequencies in the Jamaican population: a study in 100,000 newborns. Br J Haematol. 1986 Oct;64(2):253–262. doi: 10.1111/j.1365-2141.1986.tb04117.x. [DOI] [PubMed] [Google Scholar]
  15. Solanki D. L., McCurdy P. R. Cholelithiasis in sickle cell anemia: a case for elective cholecystectomy. Am J Med Sci. 1979 May-Jun;277(3):319–324. doi: 10.1097/00000441-197905000-00011. [DOI] [PubMed] [Google Scholar]
  16. Spigelman A., Warden M. J. Surgery in patients with sickle cell disease. Arch Surg. 1972 Jun;104(6):761–764. doi: 10.1001/archsurg.1972.04180060011002. [DOI] [PubMed] [Google Scholar]
  17. Stephens C. G., Scott R. B. Cholelithiasis in sickle cell anemia: surgical or medical management. Arch Intern Med. 1980 May;140(5):648–651. [PubMed] [Google Scholar]

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