Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1990 Sep;65(9):930–935. doi: 10.1136/adc.65.9.930

Slow release carbamazepine in treatment of poorly controlled seizures.

S W Ryan 1, I Forsythe 1, R Hartley 1, M Haworth 1, C J Bowmer 1
PMCID: PMC1792095  PMID: 2221963

Abstract

Thirty three children with poorly controlled epilepsy, and six new patients, were treated with slow release carbamazepine. Twelve of the former had a reduction in the number of seizures of more than half, and 10 had fewer side effects. Three of the new patients stopped having seizures. Variations in plasma concentrations between doses was significantly less when patients took the slow release preparation (22%) compared with the standard preparation (41%). Slow release carbamazepine may improve the conditions of children whose seizures are poorly controlled.

Full text

PDF
930

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aldenkamp A. P., Alpherts W. C., Moerland M. C., Ottevanger N., Van Parys J. A. Controlled release carbamazepine: cognitive side effects in patients with epilepsy. Epilepsia. 1987 Sep-Oct;28(5):507–514. doi: 10.1111/j.1528-1157.1987.tb03679.x. [DOI] [PubMed] [Google Scholar]
  2. Eeg-Olofsson O. Carbamazepine in childhood seizures. Dev Med Child Neurol. 1978 Oct;20(5):680–681. doi: 10.1111/j.1469-8749.1978.tb15294.x. [DOI] [PubMed] [Google Scholar]
  3. Gamstorp I. Treatment with carbamazepine: children. Adv Neurol. 1975;11:237–248. [PubMed] [Google Scholar]
  4. Höppener R. J., Kuyer A., Meijer J. W., Hulsman J. Correlation between daily fluctuations of carbamazepine serum levels and intermittent side effects. Epilepsia. 1980 Aug;21(4):341–350. doi: 10.1111/j.1528-1157.1980.tb04081.x. [DOI] [PubMed] [Google Scholar]
  5. Jeavons P. M. Choice of drug therapy in epilepsy. Practitioner. 1977 Oct;219(1312):542–556. [PubMed] [Google Scholar]
  6. Larkin J. G., McLellan A., Munday A., Sutherland M., Butler E., Brodie M. J. A double-blind comparison of conventional and controlled-release carbamazepine in healthy subjects. Br J Clin Pharmacol. 1989 Mar;27(3):313–322. doi: 10.1111/j.1365-2125.1989.tb05371.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Loonen A. J., Toll P. J., Nijdam J. R. A comparison of carbamazepine divitabs with carbamazepine normal formulation in psychiatric and oligophrenic patients. Preliminary pharmacokinetic results. Pharm Weekbl Sci. 1989 Feb 24;11(1):23–26. doi: 10.1007/BF01972911. [DOI] [PubMed] [Google Scholar]
  8. May T., Rambeck B. Fluctuations of carbamazepine concentrations during the day for two slow-release preparations. Ther Drug Monit. 1989;11(1):21–24. doi: 10.1097/00007691-198901000-00005. [DOI] [PubMed] [Google Scholar]
  9. Neuvonen P. J. Bioavailability and central side effects of different carbamazepine tablets. Int J Clin Pharmacol Ther Toxicol. 1985 Apr;23(4):226–232. [PubMed] [Google Scholar]
  10. O'Dougherty M., Wright F. S., Cox S., Walson P. Carbamazepine plasma concentration. Relationship to cognitive impairment. Arch Neurol. 1987 Aug;44(8):863–867. doi: 10.1001/archneur.1987.00520200065021. [DOI] [PubMed] [Google Scholar]
  11. Sivenius J., Heinonen E., Lehto H., Järvensivu P., Anttila M., Ylinen A., Riekkinen P. Reduction of dosing frequency of carbamazepine with a slow-release preparation. Epilepsy Res. 1988 Jan-Feb;2(1):32–36. doi: 10.1016/0920-1211(88)90007-1. [DOI] [PubMed] [Google Scholar]
  12. Stefan H., Schäfer H., Kuhnen C., Schneider S. Clinical monitoring during carbamazepine slow-release, once-daily monotherapy. Epilepsia. 1988 Sep-Oct;29(5):571–577. doi: 10.1111/j.1528-1157.1988.tb03763.x. [DOI] [PubMed] [Google Scholar]
  13. Tomson T. Interdosage fluctuations in plasma carbamazepine concentration determine intermittent side effects. Arch Neurol. 1984 Aug;41(8):830–834. doi: 10.1001/archneur.1984.04050190036011. [DOI] [PubMed] [Google Scholar]
  14. Troupin A. S., Green J. R., Levy R. H. Carbamazepine as an anticonvulsant: a pilot study. Neurology. 1974 Sep;24(9):863–869. doi: 10.1212/wnl.24.9.863. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES