Abstract
In a double blind, controlled trial, the effect of high dose beclomethasone dipropionate (750 micrograms three times daily for five days) administered by metered dose inhaler and valved spacer, was compared with placebo, during 70 paired episodes of acute asthma in 24 preschool children. Treatment commenced at home at the first sign of an attack. Parents' blind preference for active treatment was significant. Data from 17 pairs of treatment, however, were affected by interventions such as hospital admission or oral corticosteroid treatment. These events occurred similarly in active and control periods. An intrasubject comparison was made of diary scores from the 18 pairs of episodes in which no intervention occurred in either the active or placebo treatment. Both daytime and night symptoms over the first week of the attack were significantly reduced by active treatment. Intermittent high dose inhaled beclomethasone dipropionate is beneficial in modifying the severity of acute episodic asthma in preschool children able to use a spacer device.
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Selected References
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- Anderson H. R., Bailey P. A., Cooper J. S., Palmer J. C., West S. Morbidity and school absence caused by asthma and wheezing illness. Arch Dis Child. 1983 Oct;58(10):777–784. doi: 10.1136/adc.58.10.777. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brunette M. G., Lands L., Thibodeau L. P. Childhood asthma: prevention of attacks with short-term corticosteroid treatment of upper respiratory tract infection. Pediatrics. 1988 May;81(5):624–629. [PubMed] [Google Scholar]
- Deshpande A., McKenzie S. A. Short course of steroids in home treatment of children with acute asthma. Br Med J (Clin Res Ed) 1986 Jul 19;293(6540):169–171. doi: 10.1136/bmj.293.6540.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kattan M., Gurwitz D., Levison H. Corticosteroids in status asthmaticus. J Pediatr. 1980 Mar;96(3 Pt 2):596–599. doi: 10.1016/s0022-3476(80)80872-9. [DOI] [PubMed] [Google Scholar]
- Kravis L. P., Kolski G. B. Unexpected death in childhood asthma. A review of 13 deaths in ambulatory patients. Am J Dis Child. 1985 Jun;139(6):558–563. doi: 10.1001/archpedi.1985.02140080028026. [DOI] [PubMed] [Google Scholar]
- Loren M. L., Chai H., Leung P., Rohr C., Brenner A. M. Corticosteroids in the treatment of acute exacerbations of asthma. Ann Allergy. 1980 Aug;45(2):67–71. [PubMed] [Google Scholar]
- Luksza A. R. Acute severe asthma treated without steroids. Br J Dis Chest. 1982 Jan;76(1):15–19. [PubMed] [Google Scholar]
- Minor T. E., Dick E. C., DeMeo A. N., Ouellette J. J., Cohen M., Reed C. E. Viruses as precipitants of asthmatic attacks in children. JAMA. 1974 Jan 21;227(3):292–298. [PubMed] [Google Scholar]
- Storr J., Barrell E., Barry W., Lenney W., Hatcher G. Effect of a single oral dose of prednisolone in acute childhood asthma. Lancet. 1987 Apr 18;1(8538):879–882. doi: 10.1016/s0140-6736(87)92857-1. [DOI] [PubMed] [Google Scholar]
- Storr J., Barrell E., Lenney W. Rising asthma admissions and self referral. Arch Dis Child. 1988 Jul;63(7):774–779. doi: 10.1136/adc.63.7.774. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Webb M. S., Henry R. L., Milner A. D. Oral corticosteroids for wheezing attacks under 18 months. Arch Dis Child. 1986 Jan;61(1):15–19. doi: 10.1136/adc.61.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weinberger M. Corticosteroids for exacerbations of asthma: current status of the controversy. Pediatrics. 1988 May;81(5):726–729. [PubMed] [Google Scholar]