Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1990 Feb;65(2):189–191. doi: 10.1136/adc.65.2.189

Helicobacter pylori in Gambian children with chronic diarrhoea and malnutrition.

P B Sullivan 1, J E Thomas 1, D G Wight 1, G Neale 1, E J Eastham 1, T Corrah 1, N Lloyd-Evans 1, B M Greenwood 1
PMCID: PMC1792228  PMID: 2317065

Abstract

Infection with Helicobacter pylori (formerly Campylobacter pylori) was studied by measuring antibody titres to H pylori in Gambian children. Serological evidence of infection was found in 12 of 82 (15%) infants aged less than 20 months; this increased to 62 of 135 (46%) in those aged 40-60 months. Positive serology was found in 41 of 77 (53%) infants with chronic diarrhoea and malnutrition (mean age 19 months, range 5-36) compared with 18 of 70 (26%) of age matched healthy controls and nearly a quarter (12/49, 24%) of age matched undernourished (marasmic) subjects. These data show that infection with H pylori is common in the Gambia and that in infancy this infection is associated with chronic diarrhoea and malnutrition.

Full text

PDF
189

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berkowicz J., Lee A. Person-to-person transmission of Campylobacter pylori. Lancet. 1987 Sep 19;2(8560):680–681. doi: 10.1016/s0140-6736(87)92458-5. [DOI] [PubMed] [Google Scholar]
  2. Cave D. R., Vargas M. Effect of a Campylobacter pylori protein on acid secretion by parietal cells. Lancet. 1989 Jul 22;2(8656):187–189. doi: 10.1016/s0140-6736(89)90372-3. [DOI] [PubMed] [Google Scholar]
  3. Giannella R. A., Broitman S. A., Zamcheck N. Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Gut. 1972 Apr;13(4):251–256. doi: 10.1136/gut.13.4.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gilman R. H., Partanen R., Brown K. H., Spira W. M., Khanam S., Greenberg B., Bloom S. R., Ali A. Decreased gastric acid secretion and bacterial colonization of the stomach in severely malnourished Bangladeshi children. Gastroenterology. 1988 Jun;94(6):1308–1314. doi: 10.1016/0016-5085(88)90668-3. [DOI] [PubMed] [Google Scholar]
  5. Gledhill T., Leicester R. J., Addis B., Lightfoot N., Barnard J., Viney N., Darkin D., Hunt R. H. Epidemic hypochlorhydria. Br Med J (Clin Res Ed) 1985 May 11;290(6479):1383–1386. doi: 10.1136/bmj.290.6479.1383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gracey M., Cullity G. J., Suharjono, Sunoto The stomach in malnutrition. Arch Dis Child. 1977 Apr;52(4):325–327. doi: 10.1136/adc.52.4.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gracey M., Stone D. E. Small-intestinal microflora in Autralian Aboriginal children with chronic diarrhoea. Aust N Z J Med. 1972 Aug;2(3):215–219. doi: 10.1111/j.1445-5994.1972.tb03065.x. [DOI] [PubMed] [Google Scholar]
  8. Jones D. M., Eldridge J., Fox A. J., Sethi P., Whorwell P. J. Antibody to the gastric campylobacter-like organism ("Campylobacter pyloridis")--clinical correlations and distribution in the normal population. J Med Microbiol. 1986 Aug;22(1):57–62. doi: 10.1099/00222615-22-1-57. [DOI] [PubMed] [Google Scholar]
  9. Jones D. M., Eldridge J., Whorwell P. J. Antibodies to Campylobacter pyloridis in household contacts of infected patients. Br Med J (Clin Res Ed) 1987 Mar 7;294(6572):615–615. doi: 10.1136/bmj.294.6572.615-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kern S. E., Keren D. F., Pierson C. L. Bacterial overgrowth and mucosal changes in isolated (Thirty-Vella) ileal loops in rabbits. Effects of intraluminal antibiotics. Lab Invest. 1987 Sep;57(3):336–341. [PubMed] [Google Scholar]
  11. Mitchell H. M., Bohane T. D., Berkowicz J., Hazell S. L., Lee A. Antibody to Campylobacter pylori in families of index children with gastrointestinal illness due to C pylori. Lancet. 1987 Sep 19;2(8560):681–682. doi: 10.1016/s0140-6736(87)92459-7. [DOI] [PubMed] [Google Scholar]
  12. Morris A., Nicholson G. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol. 1987 Mar;82(3):192–199. [PubMed] [Google Scholar]
  13. Sullivan P. B., Phillips M. B., Neale G. Endoscopic capsule biopsy of the small intestine. J Pediatr Gastroenterol Nutr. 1988 Jul-Aug;7(4):544–547. doi: 10.1097/00005176-198807000-00011. [DOI] [PubMed] [Google Scholar]
  14. Ulshen M. H., Rollo J. L. Pathogenesis of escherichia coli gastroenteritis in man--another mechanism. N Engl J Med. 1980 Jan 10;302(2):99–101. doi: 10.1056/NEJM198001103020207. [DOI] [PubMed] [Google Scholar]
  15. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983 Jun 4;1(8336):1273–1275. [PubMed] [Google Scholar]
  16. Wagner S., Freise J., Beholz S., Schmidt F. W. Campylobacter pylori and gastric acidity. Am J Gastroenterol. 1989 Feb;84(2):201–202. [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES