Abstract
Blood glucose concentrations were measured prospectively in 27 small for dates infants in the first 48 hours after birth: 10 infants became hypoglycaemic. Of these, five had inappropriately raised plasma insulin concentrations. Plasma free fatty acids were lower and carbohydrate intake higher in these five infants, further supporting the diagnosis of hyperinsulinism. The hypoglycaemia recurred in four of the five hyperinsulinaemic infants, but in none of those who were not hyperinsulinaemic. Hyperinsulinism is common in small for dates babies. It is important to recognise this because hypoglycaemia is likely to recur and appropriate treatment is needed to prevent long term sequelae.
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- BARTHELMAI W., CZOK R. [Enzymatic determinations of glucose in the blood, cerebrospinal fluid and urine]. Klin Wochenschr. 1962 Jun 1;40:585–589. doi: 10.1007/BF01478633. [DOI] [PubMed] [Google Scholar]
- Bommen M., Stanhope R., Kurtz A. B., Brook C. G. Plasma C peptide in hyperinsulinaemic hypoglycaemia. Arch Dis Child. 1984 Nov;59(11):1096–1098. doi: 10.1136/adc.59.11.1096. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bonser A. M., Garcia-Webb P. C-peptide measurement and its clinical usefulness: a review. Ann Clin Biochem. 1981 Jul;18(Pt 4):200–206. doi: 10.1177/000456328101800402. [DOI] [PubMed] [Google Scholar]
- Collins J. E., Leonard J. V. Hyperinsulinism in asphyxiated and small-for-dates infants with hypoglycaemia. Lancet. 1984 Aug 11;2(8398):311–313. doi: 10.1016/s0140-6736(84)92685-0. [DOI] [PubMed] [Google Scholar]
- Girard J. R., Cuendet G. S., Marliss E. B., Kervran A., Rieutort M., Assan R. Fuels, hormones, and liver metabolism at term and during the early postnatal period in the rat. J Clin Invest. 1973 Dec;52(12):3190–3200. doi: 10.1172/JCI107519. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Le Dune M. A. Intravenous glucose tolerance and plasma insulin studies in small-for-dates infants. Arch Dis Child. 1972 Feb;47(251):111–114. doi: 10.1136/adc.47.251.111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Le Dune M. A. Response to glucagon in small-for-dates hypoglycaemic and non-hypoglycaemic newborn infants. Arch Dis Child. 1972 Oct;47(255):754–759. doi: 10.1136/adc.47.255.754. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lucas A., Morley R., Cole T. J. Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia. BMJ. 1988 Nov 19;297(6659):1304–1308. doi: 10.1136/bmj.297.6659.1304. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mehta A., Wootton R., Cheng K. N., Penfold P., Halliday D., Stacey T. E. Effect of diazoxide or glucagon on hepatic glucose production rate during extreme neonatal hypoglycaemia. Arch Dis Child. 1987 Sep;62(9):924–930. doi: 10.1136/adc.62.9.924. [DOI] [PMC free article] [PubMed] [Google Scholar]