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. 1990 Jan;65(1):74–77. doi: 10.1136/adc.65.1.74

Effect of artificial food colours on childhood behaviour.

I Pollock 1, J O Warner 1
PMCID: PMC1792406  PMID: 2301986

Abstract

We performed an objective evaluation of 39 children whose behaviour was observed by their parents to improve on an artificial food additive free diet and to deteriorate with dietary lapses. Only 19 children completed a double blind placebo controlled challenge study with artificial food colours. In these children food colours were shown to have an adverse effect on a daily Conners' rating of behaviour, but most parents could not detect these changes. A pharmacological mechanism of food additive intolerance is proposed to explain these effects.

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Selected References

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  1. Bruce-Chwatt L. J., Southgate B. A., Draper C. C. Malaria in the United Kingdom. Br Med J. 1974 Jun 29;2(5921):707–711. doi: 10.1136/bmj.2.5921.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Davidson P. O., Schrag A. R. Factors affecting the outcome of child psychiatric consultations. Am J Orthopsychiatry. 1969 Oct;39(5):774–778. doi: 10.1111/j.1939-0025.1969.tb00659.x. [DOI] [PubMed] [Google Scholar]
  3. Egger J., Carter C. M., Graham P. J., Gumley D., Soothill J. F. Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet. 1985 Mar 9;1(8428):540–545. doi: 10.1016/s0140-6736(85)91206-1. [DOI] [PubMed] [Google Scholar]
  4. Gerber J. G., Payne N. A., Oelz O., Nies A. S., Oates J. A. Tartrazine and the prostaglandin system. J Allergy Clin Immunol. 1979 Apr;63(4):289–294. doi: 10.1016/0091-6749(79)90115-5. [DOI] [PubMed] [Google Scholar]
  5. Goyette C. H., Conners C. K., Ulrich R. F. Normative data on revised Conners Parent and Teacher Rating Scales. J Abnorm Child Psychol. 1978 Jun;6(2):221–236. doi: 10.1007/BF00919127. [DOI] [PubMed] [Google Scholar]
  6. Maulitz R. M., Pratt D. S., Schocket A. L. Exercise-induced anaphylactic reaction to shellfish. J Allergy Clin Immunol. 1979 Jun;63(6):433–434. doi: 10.1016/0091-6749(79)90218-5. [DOI] [PubMed] [Google Scholar]
  7. Murdoch R. D., Lessof M. H., Pollock I., Young E. Effects of food additives on leukocyte histamine release in normal and urticaria subjects. J R Coll Physicians Lond. 1987 Oct;21(4):251–256. [PMC free article] [PubMed] [Google Scholar]
  8. Murdoch R. D., Pollock I., Naeem S. Tartrazine induced histamine release in vivo in normal subjects. J R Coll Physicians Lond. 1987 Oct;21(4):257–261. [PMC free article] [PubMed] [Google Scholar]
  9. Murdoch R. D., Pollock I., Young E., Lessof M. H. Food additive-induced urticaria: studies of mediator release during provocation tests. J R Coll Physicians Lond. 1987 Oct;21(4):262–266. [PMC free article] [PubMed] [Google Scholar]
  10. Pearson D. J. Food allergy, hypersensitivity and intolerance. J R Coll Physicians Lond. 1985 Jul;19(3):154–162. [PMC free article] [PubMed] [Google Scholar]
  11. Pollock I., Warner J. O. A follow-up study of childhood food additive intolerance. J R Coll Physicians Lond. 1987 Oct;21(4):248–250. [PMC free article] [PubMed] [Google Scholar]
  12. Swanson J. M., Kinsbourne M. Food dyes impair performance of hyperactive children on a laboratory learning test. Science. 1980 Mar 28;207(4438):1485–1487. doi: 10.1126/science.7361102. [DOI] [PubMed] [Google Scholar]
  13. Thorley G. Pilot study to assess behavioural and cognitive effects of artificial food colours in a group of retarded children. Dev Med Child Neurol. 1984 Feb;26(1):56–61. doi: 10.1111/j.1469-8749.1984.tb04406.x. [DOI] [PubMed] [Google Scholar]
  14. Weiss B., Williams J. H., Margen S., Abrams B., Caan B., Citron L. J., Cox C., McKibben J., Ogar D., Schultz S. Behavioral responses to artificial food colors. Science. 1980 Mar 28;207(4438):1487–1489. doi: 10.1126/science.7361103. [DOI] [PubMed] [Google Scholar]
  15. Weliky N., Heiner D. C. Hypersensitivity to chemicals. Correlation of tartrazine hypersensitivity with characteristic serum IgD and IgE immune response patterns. Clin Allergy. 1980 Jul;10(4):375–395. doi: 10.1111/j.1365-2222.1980.tb02121.x. [DOI] [PubMed] [Google Scholar]
  16. Young E., Patel S., Stoneham M., Rona R., Wilkinson J. D. The prevalence of reaction to food additives in a survey population. J R Coll Physicians Lond. 1987 Oct;21(4):241–247. [PMC free article] [PubMed] [Google Scholar]

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