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. 1990 Aug;65(8):874–877. doi: 10.1136/adc.65.8.874

Pseudomonas cepacia: a new pathogen in patients with cystic fibrosis referred to a large centre in the United Kingdom.

E J Simmonds 1, S P Conway 1, A T Ghoneim 1, H Ross 1, J M Littlewood 1
PMCID: PMC1792469  PMID: 2400225

Abstract

Pseudomonas cepacia infection has become increasingly common among patients with cystic fibrosis in North America. In a large cystic fibrosis centre in the United Kingdom 11 cases have been identified during the last six years, with a maximum prevalence of 7% in 1988. Three patients have died, two of whom deteriorated rapidly shortly after acquisition of the organism despite intensive treatment with appropriate antibiotics. Analysis of possible causes of the increase in P cepacia infection suggested that neither patient to patient transmission nor the use of nebulised antibiotics was associated with an increased risk of infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Hardy K. A., McGowan K. L., Fisher M. C., Schidlow D. V. Pseudomonas cepacia in the hospital setting: lack of transmission between cystic fibrosis patients. J Pediatr. 1986 Jul;109(1):51–54. doi: 10.1016/s0022-3476(86)80571-6. [DOI] [PubMed] [Google Scholar]
  2. Hodson M. E., Penketh A. R., Batten J. C. Aerosol carbenicillin and gentamicin treatment of Pseudomonas aeruginosa infection in patients with cystic fibrosis. Lancet. 1981 Nov 21;2(8256):1137–1139. doi: 10.1016/s0140-6736(81)90588-2. [DOI] [PubMed] [Google Scholar]
  3. Isles A., Maclusky I., Corey M., Gold R., Prober C., Fleming P., Levison H. Pseudomonas cepacia infection in cystic fibrosis: an emerging problem. J Pediatr. 1984 Feb;104(2):206–210. doi: 10.1016/s0022-3476(84)80993-2. [DOI] [PubMed] [Google Scholar]
  4. LiPuma J. J., Mortensen J. E., Dasen S. E., Edlind T. D., Schidlow D. V., Burns J. L., Stull T. L. Ribotype analysis of Pseudomonas cepacia from cystic fibrosis treatment centers. J Pediatr. 1988 Nov;113(5):859–862. doi: 10.1016/s0022-3476(88)80018-0. [DOI] [PubMed] [Google Scholar]
  5. Littlewood J. M., Miller M. G., Ghoneim A. T., Ramsden C. H. Nebulised colomycin for early pseudomonas colonisation in cystic fibrosis. Lancet. 1985 Apr 13;1(8433):865–865. doi: 10.1016/s0140-6736(85)92222-6. [DOI] [PubMed] [Google Scholar]
  6. McKevitt A. I., Woods D. E. Characterization of Pseudomonas cepacia isolates from patients with cystic fibrosis. J Clin Microbiol. 1984 Feb;19(2):291–293. doi: 10.1128/jcm.19.2.291-293.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. SHWACHMAN H., KULCZYCKI L. L. Long-term study of one hundred five patients with cystic fibrosis; studies made over a five- to fourteen-year period. AMA J Dis Child. 1958 Jul;96(1):6–15. doi: 10.1001/archpedi.1958.02060060008002. [DOI] [PubMed] [Google Scholar]
  8. Tablan O. C., Chorba T. L., Schidlow D. V., White J. W., Hardy K. A., Gilligan P. H., Morgan W. M., Carson L. A., Martone W. J., Jason J. M. Pseudomonas cepacia colonization in patients with cystic fibrosis: risk factors and clinical outcome. J Pediatr. 1985 Sep;107(3):382–387. doi: 10.1016/s0022-3476(85)80511-4. [DOI] [PubMed] [Google Scholar]
  9. Tablan O. C., Martone W. J., Doershuk C. F., Stern R. C., Thomassen M. J., Klinger J. D., White J. W., Carson L. A., Jarvis W. R. Colonization of the respiratory tract with Pseudomonas cepacia in cystic fibrosis. Risk factors and outcomes. Chest. 1987 Apr;91(4):527–532. doi: 10.1378/chest.91.4.527. [DOI] [PubMed] [Google Scholar]
  10. Tablan O. C., Martone W. J., Jarvis W. R. The epidemiology of Pseudomonas cepacia in patients with cystic fibrosis. Eur J Epidemiol. 1987 Dec;3(4):336–342. doi: 10.1007/BF00145642. [DOI] [PubMed] [Google Scholar]
  11. Thomassen M. J., Demko C. A., Doershuk C. F., Stern R. C., Klinger J. D. Pseudomonas cepacia: decrease in colonization in patients with cystic fibrosis. Am Rev Respir Dis. 1986 Oct;134(4):669–671. doi: 10.1164/arrd.1986.134.4.669. [DOI] [PubMed] [Google Scholar]
  12. Thomassen M. J., Demko C. A., Klinger J. D., Stern R. C. Pseudomonas cepacia colonization among patients with cystic fibrosis. A new opportunist. Am Rev Respir Dis. 1985 May;131(5):791–796. doi: 10.1164/arrd.1985.131.5.791. [DOI] [PubMed] [Google Scholar]
  13. Tomashefski J. F., Thomassen M. J., Bruce M. C., Goldberg H. I., Konstan M. W., Stern R. C. Pseudomonas cepacia-associated pneumonia in cystic fibrosis. Relation of clinical features to histopathologic patterns of pneumonia. Arch Pathol Lab Med. 1988 Feb;112(2):166–172. [PubMed] [Google Scholar]

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