Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1989 Aug;64(8):1140–1145. doi: 10.1136/adc.64.8.1140

Vertical transmission of HIV: a prospective study.

J Y Mok 1, R A Hague 1, P L Yap 1, F D Hargreaves 1, J M Inglis 1, J M Whitelaw 1, C M Steel 1, O B Eden 1, S Rebus 1, J F Peutherer 1, et al.
PMCID: PMC1792513  PMID: 2782927

Abstract

Forty nine infants of HIV seropositive women were followed up for a median of 24 months, together with 24 controls. The infection status of 11 index children under 18 months of age was indeterminate; 34 were presumed uninfected while four showed clinical and laboratory evidence of HIV disease. Based on current definitions of HIV infection and excluding children under 18 months old as well as those who had not been studied from birth, two out of 28 children were infected. The estimated rate of maternofetal transmission was therefore 7.1%. In children with proved infection, sequential laboratory data showed that hypergammaglobulinaemia was noted as early as 6 months and often predated clinical signs. This observation, in the presence of non-specific clinical findings, was helpful in alerting the paediatrician to a diagnosis of HIV infection.

Full text

PDF
1140

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aiuti F., Luzi G., Mezzaroma I., Scano G., Papetti C. Delayed appearance of HIV infection in children. Lancet. 1987 Oct 10;2(8563):858–858. doi: 10.1016/s0140-6736(87)91047-6. [DOI] [PubMed] [Google Scholar]
  2. Amadori A., de Rossi A., Giaquinto C., Faulkner-Valle G., Zacchello F., Chieco-Bianchi L. In-vitro production of HIV-specific antibody in children at risk of AIDS. Lancet. 1988 Apr 16;1(8590):852–854. doi: 10.1016/s0140-6736(88)91603-0. [DOI] [PubMed] [Google Scholar]
  3. Borkowsky W., Krasinski K., Paul D., Moore T., Bebenroth D., Chandwani S. Human-immunodeficiency-virus infections in infants negative for anti-HIV by enzyme-linked immunoassay. Lancet. 1987 May 23;1(8543):1168–1171. doi: 10.1016/s0140-6736(87)92143-x. [DOI] [PubMed] [Google Scholar]
  4. Brettle R. P., Bisset K., Burns S., Davidson J., Davidson S. J., Gray J. M., Inglis J. M., Lees J. S., Mok J. Human immunodeficiency virus and drug misuse: the Edinburgh experience. Br Med J (Clin Res Ed) 1987 Aug 15;295(6595):421–424. doi: 10.1136/bmj.295.6595.421. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Centers for Disease Control (CDC) Classification system for human immunodeficiency virus (HIV) infection in children under 13 years of age. MMWR Morb Mortal Wkly Rep. 1987 Apr 24;36(15):225-30, 235-6. [PubMed] [Google Scholar]
  6. Johnstone F. D., MacCallum L., Brettle R., Inglis J. M., Peutherer J. F. Does infection with HIV affect the outcome of pregnancy? Br Med J (Clin Res Ed) 1988 Feb 13;296(6620):467–467. doi: 10.1136/bmj.296.6620.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Jovaisas E., Koch M. A., Schäfer A., Stauber M., Löwenthal D. LAV/HTLV-III in 20-week fetus. Lancet. 1985 Nov 16;2(8464):1129–1129. doi: 10.1016/s0140-6736(85)90720-2. [DOI] [PubMed] [Google Scholar]
  8. Lapointe N., Michaud J., Pekovic D., Chausseau J. P., Dupuy J. M. Transplacental transmission of HTLV-III virus. N Engl J Med. 1985 May 16;312(20):1325–1326. doi: 10.1056/NEJM198505163122012. [DOI] [PubMed] [Google Scholar]
  9. Laure F., Courgnaud V., Rouzioux C., Blanche S., Veber F., Burgard M., Jacomet C., Griscelli C., Brechot C. Detection of HIV1 DNA in infants and children by means of the polymerase chain reaction. Lancet. 1988 Sep 3;2(8610):538–541. doi: 10.1016/s0140-6736(88)92659-1. [DOI] [PubMed] [Google Scholar]
  10. Marion R. W., Wiznia A. A., Hutcheon G., Rubinstein A. Human T-cell lymphotropic virus type III (HTLV-III) embryopathy. A new dysmorphic syndrome associated with intrauterine HTLV-III infection. Am J Dis Child. 1986 Jul;140(7):638–640. doi: 10.1001/archpedi.1986.02140210036020. [DOI] [PubMed] [Google Scholar]
  11. Minkoff H., Nanda D., Menez R., Fikrig S. Pregnancies resulting in infants with acquired immunodeficiency syndrome or AIDS-related complex: follow-up of mothers, children, and subsequently born siblings. Obstet Gynecol. 1987 Mar;69(3 Pt 1):288–291. [PubMed] [Google Scholar]
  12. Mok J. Q., Giaquinto C., De Rossi A., Grosch-Wörner I., Ades A. E., Peckham C. S. Infants born to mothers seropositive for human immunodeficiency virus. Preliminary findings from a multicentre European study. Lancet. 1987 May 23;1(8543):1164–1168. doi: 10.1016/s0140-6736(87)92142-8. [DOI] [PubMed] [Google Scholar]
  13. Oleske J., Minnefor A., Cooper R., Jr, Thomas K., dela Cruz A., Ahdieh H., Guerrero I., Joshi V. V., Desposito F. Immune deficiency syndrome in children. JAMA. 1983 May 6;249(17):2345–2349. [PubMed] [Google Scholar]
  14. Ou C. Y., Kwok S., Mitchell S. W., Mack D. H., Sninsky J. J., Krebs J. W., Feorino P., Warfield D., Schochetman G. DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells. Science. 1988 Jan 15;239(4837):295–297. doi: 10.1126/science.3336784. [DOI] [PubMed] [Google Scholar]
  15. Rubinstein A., Sicklick M., Gupta A., Bernstein L., Klein N., Rubinstein E., Spigland I., Fruchter L., Litman N., Lee H. Acquired immunodeficiency with reversed T4/T8 ratios in infants born to promiscuous and drug-addicted mothers. JAMA. 1983 May 6;249(17):2350–2356. [PubMed] [Google Scholar]
  16. Scott G. B., Buck B. E., Leterman J. G., Bloom F. L., Parks W. P. Acquired immunodeficiency syndrome in infants. N Engl J Med. 1984 Jan 12;310(2):76–81. doi: 10.1056/NEJM198401123100202. [DOI] [PubMed] [Google Scholar]
  17. Sprecher S., Soumenkoff G., Puissant F., Degueldre M. Vertical transmission of HIV in 15-week fetus. Lancet. 1986 Aug 2;2(8501):288–289. doi: 10.1016/s0140-6736(86)92110-0. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES