Abstract
We have analysed the cause of perinatal deaths in four hospitals in the North West Thames region over a six year period commencing January 1980. The Pakistani population had a significantly greater perinatal mortality rate (15.7/1000 births) than the Europeans (11.3/1000 births). This was due to an increased incidence of macerated stillbirths and lethal malformations, the latter resulting from a significantly higher incidence of autosomal recessive disorders, neural tube defects, and renal malformations.
Full text
PDF![1036](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a58/1792701/9f1b0dfbad9b/archdisch00672-0066.png)
![1037](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a58/1792701/6497d8c12987/archdisch00672-0067.png)
![1038](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a58/1792701/c0725597412a/archdisch00672-0068.png)
![1039](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a58/1792701/b6e2c318a175/archdisch00672-0069.png)
![1040](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a58/1792701/3ffbcbbdd91d/archdisch00672-0070.png)
![1041](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a58/1792701/07e79c541cdb/archdisch00672-0071.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Darr A., Modell B. The frequency of consanguineous marriage among British Pakistanis. J Med Genet. 1988 Mar;25(3):186–190. doi: 10.1136/jmg.25.3.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gillies D. R., Lealman G. T., Lumb K. M., Congdon P. Analysis of ethnic influence on stillbirths and infant mortality in Bradford 1975-81. J Epidemiol Community Health. 1984 Sep;38(3):214–217. doi: 10.1136/jech.38.3.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hall J. G. Analysis of Pena Shokeir phenotype. Am J Med Genet. 1986 Sep;25(1):99–117. doi: 10.1002/ajmg.1320250112. [DOI] [PubMed] [Google Scholar]
- Lumb K. M., Congdon P. J., Lealman G. T. A comparative review of Asian and British-born maternity patients in Bradford, 1974-8. J Epidemiol Community Health. 1981 Jun;35(2):106–109. doi: 10.1136/jech.35.2.106. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Modell B., Ward R. H., Fairweather D. V. Effect of introducing antenatal diagnosis on reproductive behaviour of families at risk for thalassaemia major. Br Med J. 1980 Jun 7;280(6228):1347–1350. doi: 10.1136/bmj.280.6228.1347. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morris J. A., Gardner M. J. Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates. Br Med J (Clin Res Ed) 1988 May 7;296(6632):1313–1316. doi: 10.1136/bmj.296.6632.1313. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Seller M. J., Nevin N. C. Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland. J Med Genet. 1984 Oct;21(5):325–330. doi: 10.1136/jmg.21.5.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Terry P. B., Bissenden J. G., Condie R. G., Mathew P. M. Ethnic differences in congenital malformations. Arch Dis Child. 1985 Sep;60(9):866–868. doi: 10.1136/adc.60.9.866. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Terry P. B., Condie R. G., Settatree R. S. Analysis of ethnic differences in perinatal statistics. Br Med J. 1980 Nov 15;281(6251):1307–1308. doi: 10.1136/bmj.281.6251.1307. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tolmie J. L., Mortimer G., Doyle D., McKenzie R., McLaurin J., Neilson J. P. The Neu-Laxova syndrome in female sibs: clinical and pathological features with prenatal diagnosis in the second sib. Am J Med Genet. 1987 May;27(1):175–182. doi: 10.1002/ajmg.1320270118. [DOI] [PubMed] [Google Scholar]
- Wigglesworth J. S. Monitoring perinatal mortality. A pathophysiological approach. Lancet. 1980 Sep 27;2(8196):684–686. doi: 10.1016/s0140-6736(80)92717-8. [DOI] [PubMed] [Google Scholar]
- Winter R. M., Knowles S. A. Megacystis-microcolon-intestinal hypoperistalsis syndrome: confirmation of autosomal recessive inheritance. J Med Genet. 1986 Aug;23(4):360–362. doi: 10.1136/jmg.23.4.360. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Young I. D., Rickett A. B., Clarke M. Genetic analysis of malformations causing perinatal mortality. J Med Genet. 1986 Feb;23(1):58–63. doi: 10.1136/jmg.23.1.58. [DOI] [PMC free article] [PubMed] [Google Scholar]