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. 1989 Sep;64(9):1264–1269. doi: 10.1136/adc.64.9.1264

Neonatal renal function assessment.

P M Clark 1, T N Bryant 1, M A Hall 1, J A Lowes 1, D J Rowe 1
PMCID: PMC1792728  PMID: 2817946

Abstract

Urine samples from neonates admitted to a special care baby unit were analysed to establish ranges for urinary retinol binding protein, albumin, and total protein concentrations in healthy term and preterm infants and to investigate changes seen in disease states. Urinary excretion of retinol binding protein was greater in preterm infants and was increased in sick infants. This was greater than would be predicted from changes in creatinine excretion with gestational or postconceptional age. Urinary retinol binding protein appeared more sensitive to illness than did urinary albumin or total protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernard A. M., Moreau D., Lauwerys R. Comparison of retinol-binding protein and beta 2-microglobulin determination in urine for the early detection of tubular proteinuria. Clin Chim Acta. 1982 Nov 24;126(1):1–7. doi: 10.1016/0009-8981(82)90356-4. [DOI] [PubMed] [Google Scholar]
  2. Cole J. W., Portman R. J., Lim Y., Perlman J. M., Robson A. M. Urinary beta 2-microglobulin in full-term newborns: evidence for proximal tubular dysfunction in infants with meconium-stained amniotic fluid. Pediatrics. 1985 Dec;76(6):958–964. [PubMed] [Google Scholar]
  3. Guignard J. P., Torrado A., Da Cunha O., Gautier E. Glomerular filtration rate in the first three weeks of life. J Pediatr. 1975 Aug;87(2):268–272. doi: 10.1016/s0022-3476(75)80600-7. [DOI] [PubMed] [Google Scholar]
  4. Hall M. A., Ducker D. A., Lowes J. A., McMichael J., Clarke P., Rowe D., Gordon A., Cole D. S. A randomised prospective comparison of cefotaxime versus netilmicin/penicillin for treatment of suspected neonatal sepsis. Drugs. 1988;35 (Suppl 2):169–177. doi: 10.2165/00003495-198800352-00036. [DOI] [PubMed] [Google Scholar]
  5. Howells D. W., Levin G. E., Brown I. R., Brooke O. G. Plasma retinol and retinol-binding protein in pre-term infants born small for gestational age or of appropriate weight for age. Hum Nutr Clin Nutr. 1984 Mar;38(2):107–111. [PubMed] [Google Scholar]
  6. Ismadi S. D., Olson J. A. Vitamin A transport in human fetal blood. Am J Clin Nutr. 1975 Sep;28(9):967–972. doi: 10.1093/ajcn/28.9.967. [DOI] [PubMed] [Google Scholar]
  7. Iwata J., Nishikaze O. New micro-turbidimetric method for determination of protein in cerebrospinal fluid and urine. Clin Chem. 1979 Jul;25(7):1317–1319. [PubMed] [Google Scholar]
  8. Maack T., Johnson V., Kau S. T., Figueiredo J., Sigulem D. Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review. Kidney Int. 1979 Sep;16(3):251–270. doi: 10.1038/ki.1979.128. [DOI] [PubMed] [Google Scholar]
  9. Mogensen C. E., Christensen C. K. Predicting diabetic nephropathy in insulin-dependent patients. N Engl J Med. 1984 Jul 12;311(2):89–93. doi: 10.1056/NEJM198407123110204. [DOI] [PubMed] [Google Scholar]
  10. Rowe D. J., Anthony F., Polak A., Shaw K., Ward C. D., Watts G. F. Retinol binding protein as a small molecular weight marker of renal tubular function in diabetes mellitus. Ann Clin Biochem. 1987 Sep;24(Pt 5):477–482. doi: 10.1177/000456328702400509. [DOI] [PubMed] [Google Scholar]
  11. Rowe D. J., Hayward M., Bagga H., Betts P. Effect of glycaemic control and duration of disease on overnight albumin excretion in diabetic children. Br Med J (Clin Res Ed) 1984 Oct 13;289(6450):957–959. doi: 10.1136/bmj.289.6450.957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rudd P. T., Hughes E. A., Placzek M. M., Hodes D. T. Reference ranges for plasma creatinine during the first month of life. Arch Dis Child. 1983 Mar;58(3):212–215. doi: 10.1136/adc.58.3.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sertel H., Scopes J. Rates of creatinine clearance in babies less than one week of age. Arch Dis Child. 1973 Sep;48(9):717–720. doi: 10.1136/adc.48.9.717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Siegel S. R., Oh W. Renal function as a marker of human fetal maturation. Acta Paediatr Scand. 1976 Jul;65(4):481–485. doi: 10.1111/j.1651-2227.1976.tb04917.x. [DOI] [PubMed] [Google Scholar]
  15. Usher R. H., Allen A. C., McLean F. H. Risk of respiratory distress syndrome related to gestational age, route of delivery, and maternal diabetes. Am J Obstet Gynecol. 1971 Nov;111(6):826–832. doi: 10.1016/0002-9378(71)90495-9. [DOI] [PubMed] [Google Scholar]
  16. Viberti G. C., Hill R. D., Jarrett R. J., Argyropoulos A., Mahmud U., Keen H. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet. 1982 Jun 26;1(8287):1430–1432. doi: 10.1016/s0140-6736(82)92450-3. [DOI] [PubMed] [Google Scholar]

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