Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1989 Dec;64(12):1656–1660. doi: 10.1136/adc.64.12.1656

Interferon alfa, infectious virus, and virus antigen secretion in respiratory syncytial virus infections of graded severity.

C E Taylor 1, M S Webb 1, A D Milner 1, P D Milner 1, L A Morgan 1, R Scott 1, G M Stokes 1, A S Swarbrick 1, G L Toms 1
PMCID: PMC1792921  PMID: 2624471

Abstract

Interferon alfa was measured by an immunoradiometric assay in the nasopharyngeal secretions of a group of infants admitted to hospital with respiratory syncytial virus infection. Virus replication in the upper respiratory tract was assessed by infectivity assay and by an enzyme linked immunoadsorbent assay for the viral fusion protein on the same nasopharyngeal secretions. All infants were examined daily while in hospital and allocated a score based upon a subjective assessment of the severity of their illness. There was no significant correlation between interferon, virus, or fusion (F) protein secretion and severity of illness or age of infant. It is concluded that poor interferon alfa secretion does not underly the susceptibility of infants to severe infections with this virus.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chonmaitree T., Roberts N. J., Jr, Douglas R. G., Jr, Hall C. B., Simons R. L. Interferon production by human mononuclear leukocytes: differences between respiratory syncytial virus and influenza viruses. Infect Immun. 1981 Apr;32(1):300–303. doi: 10.1128/iai.32.1.300-303.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gardner P. S., McGuckin R., Beale A., Fernandes R. Interferon and respiratory syncytial virus. Lancet. 1970 Mar 14;1(7646):574–575. doi: 10.1016/s0140-6736(70)90821-4. [DOI] [PubMed] [Google Scholar]
  3. Hall C. B., Douglas R. G., Jr, Geiman J. M. Quantitative shedding patterns of respiratory syncytial virus in infants. J Infect Dis. 1975 Aug;132(2):151–156. doi: 10.1093/infdis/132.2.151. [DOI] [PubMed] [Google Scholar]
  4. Hall C. B., Douglas R. G., Jr, Geiman J. M. Respiratory syncytial virus infections in infants: quantitation and duration of shedding. J Pediatr. 1976 Jul;89(1):11–15. doi: 10.1016/s0022-3476(76)80918-3. [DOI] [PubMed] [Google Scholar]
  5. Hall C. B., Douglas R. G., Jr, Simons R. L., Geiman J. M. Interferon production in children with respiratory syncytial, influenza, and parainfluenza virus infections. J Pediatr. 1978 Jul;93(1):28–32. doi: 10.1016/s0022-3476(78)80594-0. [DOI] [PubMed] [Google Scholar]
  6. Hall C. B., Douglas R. G., Jr, Simons R. L. Interferon production in adults with respiratory syncytial viral infection. Ann Intern Med. 1981 Jan;94(1):53–55. doi: 10.7326/0003-4819-94-1-53. [DOI] [PubMed] [Google Scholar]
  7. Henry R., Milner A. D., Stokes G. M. Bronchiolitis. Am J Dis Child. 1983 Aug;137(8):805–806. doi: 10.1001/archpedi.1983.02140340085025. [DOI] [PubMed] [Google Scholar]
  8. Hoshino A., Takenaka H., Mizukoshi O., Imanishi J., Kishida T., Tovey M. G. Effect of anti-interferon serum of influenza virus infection in mice. Antiviral Res. 1983 Mar;3(1):59–65. doi: 10.1016/0166-3542(83)90015-3. [DOI] [PubMed] [Google Scholar]
  9. Husseini R. H., Sweet C., Collie M. H., Smith H. The relation of interferon and nonspecific inhibitors to virus levels in nasal washes of ferrets infected with influenza viruses of differing virulence. Br J Exp Pathol. 1981 Feb;62(1):87–93. [PMC free article] [PubMed] [Google Scholar]
  10. Isaacs D., Clarke J. R., Tyrrell D. A., Webster A. D., Valman H. B. Deficient production of leucocyte interferon (interferon-alpha) in vitro and in vivo in children with recurrent respiratory tract infections. Lancet. 1981 Oct 31;2(8253):950–952. doi: 10.1016/s0140-6736(81)91153-3. [DOI] [PubMed] [Google Scholar]
  11. Juhlin L., Cantell K. Interferon response of lymphocytes and resistance to infections. Lancet. 1978 Mar 25;1(8065):667–668. doi: 10.1016/s0140-6736(78)91179-0. [DOI] [PubMed] [Google Scholar]
  12. McIntosh K. Interferon in nasal secretions from infants with viral respiratory tract infections. J Pediatr. 1978 Jul;93(1):33–36. doi: 10.1016/s0022-3476(78)80595-2. [DOI] [PubMed] [Google Scholar]
  13. McLaren C., Potter C. W. The relationship between interferon and virus virulence in influenza virus infections of the mouse. J Med Microbiol. 1973 Feb;6(1):21–32. doi: 10.1099/00222615-6-1-21. [DOI] [PubMed] [Google Scholar]
  14. Morgan L. A., Routledge E. G., Willcocks M. M., Samson A. C., Scott R., Toms G. L. Strain variation of respiratory syncytial virus. J Gen Virol. 1987 Nov;68(Pt 11):2781–2788. doi: 10.1099/0022-1317-68-11-2781. [DOI] [PubMed] [Google Scholar]
  15. Routledge E. G., McQuillin J., Samson A. C., Toms G. L. The development of monoclonal antibodies to respiratory syncytial virus and their use in diagnosis by indirect immunofluorescence. J Med Virol. 1985 Mar;15(3):305–320. doi: 10.1002/jmv.1890150311. [DOI] [PubMed] [Google Scholar]
  16. Routledge E. G., Willcocks M. M., Samson A. C., Morgan L., Scott R., Anderson J. J., Toms G. L. The purification of four respiratory syncytial virus proteins and their evaluation as protective agents against experimental infection in BALB/c mice. J Gen Virol. 1988 Feb;69(Pt 2):293–303. doi: 10.1099/0022-1317-69-2-293. [DOI] [PubMed] [Google Scholar]
  17. Scott R., Pullan C. R., Scott M., McQuillin J. Cell-mediated immunity in respiratory syncytial virus disease. J Med Virol. 1984;13(1):105–114. doi: 10.1002/jmv.1890130112. [DOI] [PubMed] [Google Scholar]
  18. Sims D. G., Downham M. A., McQuillin J., Gardner P. S. Respiratory syncytial virus infection in north-east England. Br Med J. 1976 Nov 6;2(6044):1095–1098. doi: 10.1136/bmj.2.6044.1095. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Taylor C. E., Craft A. W., Kernahan J., Reid M. M., Toms G. L. Nasal interferon responses in leukaemia. Arch Dis Child. 1985 Sep;60(9):829–831. doi: 10.1136/adc.60.9.829. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES