Abstract
Sixty five neonates with confirmed symptomatic congenital cytomegalovirus infection were followed up prospectively until they were 3 to 4 year of age. Twenty nine children (45%) had neurological impairment of whom 22 had gross motor or psychomotor abnormalities; in the remaining seven sensorineural deafness was the main abnormality. Infants who had had neurological signs during the neonatal period had a worse prognosis than those who had not, with 16/22 (73%) and 13/43 (30%) having neurological deficit at follow up, respectively. Our results indicate that the prognosis for infants with symptomatic congenital cytomegalovirus infection is better than previously reported.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bale J. F., Jr, Blackman J. A., Sato Y. Outcome in children with symptomatic congenital cytomegalovirus infection. J Child Neurol. 1990 Apr;5(2):131–136. doi: 10.1177/088307389000500212. [DOI] [PubMed] [Google Scholar]
- Berenberg W., Nankervis G. Long-term follow-up of cytomegalic inclusion disease of infancy. Pediatrics. 1970 Sep;46(3):403–410. [PubMed] [Google Scholar]
- Conboy T. J., Pass R. F., Stagno S., Alford C. A., Myers G. J., Britt W. J., McCollister F. P., Summers M. N., McFarland C. E., Boll T. J. Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr. 1987 Sep;111(3):343–348. doi: 10.1016/s0022-3476(87)80451-1. [DOI] [PubMed] [Google Scholar]
- Gairdner D., Pearson J. A growth chart for premature and other infants. Arch Dis Child. 1971 Dec;46(250):783–787. doi: 10.1136/adc.46.250.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hanshaw J. B., Scheiner A. P., Moxley A. W., Gaev L., Abel V., Scheiner B. School failure and deafness after "silent" congenital cytomegalovirus infection. N Engl J Med. 1976 Aug 26;295(9):468–470. doi: 10.1056/NEJM197608262950902. [DOI] [PubMed] [Google Scholar]
- Kumar M. L., Nankervis G. A., Gold E. Inapparent congenital cytomegalovirus infection. A follow-up study. N Engl J Med. 1973 Jun 28;288(26):1370–1372. doi: 10.1056/NEJM197306282882603. [DOI] [PubMed] [Google Scholar]
- MEDEARIS D. N., Jr Cytomegalic inclusion disease; an analysis of the clinical features based on the literature and six additional cases. Pediatrics. 1957 Mar;19(3):467–480. [PubMed] [Google Scholar]
- McCracken G. H., Jr, Shinefield H. M., Cobb K., Rausen A. R., Dische R., Eichenwald H. F. Congenital cytomegalic inclusion disease. A longitudinal study of 20 patients. Am J Dis Child. 1969 May;117(5):522–539. doi: 10.1001/archpedi.1969.02100030524005. [DOI] [PubMed] [Google Scholar]
- Pass R. F., Stagno S., Myers G. J., Alford C. A. Outcome of symptomatic congenital cytomegalovirus infection: results of long-term longitudinal follow-up. Pediatrics. 1980 Nov;66(5):758–762. [PubMed] [Google Scholar]
- Peckham C. S., Johnson C., Ades A., Pearl K., Chin K. S. Early acquisition of cytomegalovirus infection. Arch Dis Child. 1987 Aug;62(8):780–785. doi: 10.1136/adc.62.8.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Preece P. M., Pearl K. N., Peckham C. S. Congenital cytomegalovirus infection. Arch Dis Child. 1984 Dec;59(12):1120–1126. doi: 10.1136/adc.59.12.1120. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WELLER T. H., HANSHAW J. B. Virologic and clinical observations on cytomegalic inclusion disease. N Engl J Med. 1962 Jun 14;266:1233–1244. doi: 10.1056/NEJM196206142662401. [DOI] [PubMed] [Google Scholar]