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. 1991 Jun;66(6):683–685. doi: 10.1136/adc.66.6.683

Changes in periurethral microflora after antimicrobial drugs.

K J Lidefelt 1, I Bollgren 1, C E Nord 1
PMCID: PMC1793161  PMID: 2053786

Abstract

The periurethral flora was examined in 18 girls by use of a quantitative sampling method before, during, and three weeks after treatment with antibiotics for upper respiratory tract infections. Eight girls received amoxicillin. In five of them the anaerobic flora showed a reduction in total counts and in numbers of different species, and all eight girls got a heavy colonisation with enterobacteria during treatment. Three weeks after treatment the anaerobic and aerobic flora had reversed to the pretreatment composition. In 10 girls treated with trimethoprim-sulphamethoxazole the anaerobic flora remained unaffected and no enterobacterial overgrowth was registered during the study period. We propose that antibiotics could be one among several factors involved in the pathogenesis of urinary tract infection, by suppression of the anaerobic microflora and promotion of the colonisation with enterobacteria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennet R., Eriksson M., Nord C. E., Zetterström R. Suppression of aerobic and anaerobic faecal flora in newborns receiving parenteral gentamicin and ampicillin. Acta Paediatr Scand. 1982 Jul;71(4):559–562. doi: 10.1111/j.1651-2227.1982.tb09474.x. [DOI] [PubMed] [Google Scholar]
  2. Bollgren I., Källenius G., Nord C. E., Winberg J. Periurethral anaerobic microflora of healthy girls. J Clin Microbiol. 1979 Oct;10(4):419–424. doi: 10.1128/jcm.10.4.419-424.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bollgren I., Nord C. E., Pettersson L., Winberg J. Periurethral anaerobic microflora in girls highly susceptible to urinary tract infections. J Urol. 1981 May;125(5):715–720. doi: 10.1016/s0022-5347(17)55178-2. [DOI] [PubMed] [Google Scholar]
  4. Bollgren I., Winberg J. The periurethral aerobic flora in girls highly susceptible to urinary infections. Acta Paediatr Scand. 1976 Jan;65(1):81–87. doi: 10.1111/j.1651-2227.1976.tb04411.x. [DOI] [PubMed] [Google Scholar]
  5. FRETER R. The fatal enteric cholera infection in the guinea pig, achieved by inhibition of normal enteric flora. J Infect Dis. 1955 Jul-Aug;97(1):57–65. doi: 10.1093/infdis/97.1.57. [DOI] [PubMed] [Google Scholar]
  6. Heimdahl A., Nord C. E. Effect of erythromycin and clindamycin on the indigenous human anaerobic flora and new colonization of the gastrointestinal tract. Eur J Clin Microbiol. 1982 Feb;1(1):38–48. doi: 10.1007/BF02014139. [DOI] [PubMed] [Google Scholar]
  7. Herthelius B. M., Hedström K. G., Möllby R., Nord C. E., Pettersson L., Winberg J. Pathogenesis of urinary tract infections--amoxicillin induces genital Escherichia coli colonization. Infection. 1988 Sep-Oct;16(5):263–266. doi: 10.1007/BF01645066. [DOI] [PubMed] [Google Scholar]
  8. Herthelius M., Möllby R., Nord C. E., Winberg J. Amoxicillin promotes vaginal colonization with adhering Escherichia coli present in faeces. Pediatr Nephrol. 1989 Oct;3(4):443–447. doi: 10.1007/BF00850224. [DOI] [PubMed] [Google Scholar]
  9. Mackowiak P. A. The normal microbial flora. N Engl J Med. 1982 Jul 8;307(2):83–93. doi: 10.1056/NEJM198207083070203. [DOI] [PubMed] [Google Scholar]
  10. Mårild S., Jodal U., Mangelus L. Medical histories of children with acute pyelonephritis compared with controls. Pediatr Infect Dis J. 1989 Aug;8(8):511–515. doi: 10.1097/00006454-198908000-00008. [DOI] [PubMed] [Google Scholar]
  11. Reid G., Bruce A. W., Cook R. L., Llano M. Effect on urogenital flora of antibiotic therapy for urinary tract infection. Scand J Infect Dis. 1990;22(1):43–47. doi: 10.3109/00365549009023118. [DOI] [PubMed] [Google Scholar]
  12. Ronald A. R., Jagdis F. A., Harding G. K., Hoban S. A., Miur P. L., Gurwith M. J. Amoxicillin therapy of acute urinary infections in adults. Antimicrob Agents Chemother. 1977 May;11(5):780–784. doi: 10.1128/aac.11.5.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sprunt K., Redman W. Evidence suggesting importance of role of interbacterial inhibition in maintaining balance of normal flora. Ann Intern Med. 1968 Mar;68(3):579–590. doi: 10.7326/0003-4819-68-3-579. [DOI] [PubMed] [Google Scholar]
  14. Stamey T. A., Timothy M., Millar M., Mihara G. Recurrent urinary infections in adult women. The role of introital enterobacteria. Calif Med. 1971 Jul;115(1):1–19. [PMC free article] [PubMed] [Google Scholar]
  15. van der Waaij D., Berghuis-de Vries J. M., Lekkerkerk Lekkerkerk-v Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. J Hyg (Lond) 1971 Sep;69(3):405–411. doi: 10.1017/s0022172400021653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. van der Waaij D., de Vries-Hospers H. G., Welling G. W. The influence of antibiotics on gut colonization. J Antimicrob Chemother. 1986 Oct;18 (Suppl 100):155–158. doi: 10.1093/jac/18.supplement_c.155. [DOI] [PubMed] [Google Scholar]

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