Skip to main content
NCBI home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1991 Jan;66(1):140–142. doi: 10.1136/adc.66.1.140

Mineral balance in infantile cortical hyperostosis: effects of corticosteroids.

D G Barr 1, N R Belton 1
PMCID: PMC1793178  PMID: 1847282

Abstract

The effects on mineral metabolism of therapeutic doses of corticosteroids were investigated in infantile cortical hyperostosis; in four untreated cases the calcium, phosphorus, and magnesium balances were strongly positive. In one severe case, treatment with prednisolone was associated with an alteration to negative calcium and magnesium balance, and faecal losses of calcium were particularly high. This effect persisted for at least three months after the steroids had been discontinued, and during this period there was pronounced retardation of linear growth. Six months after the treatment had been stopped mineral balance was again positive and there was rapid 'catch up' in growth. In infancy, the negative effect of corticosteroids on calcium, phosphorus, and magnesium metabolism may contribute to inhibition of bone growth and steroid stunting.

Full text

PDF
140

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLODGETT F. M., BURGIN L., IEZZONI D., GRIBETZ D., TALBOT N. B. Effects of prolonged cortisone therapy on the statural growth, skeletal maturation and metabolic status of children. N Engl J Med. 1956 Apr 5;254(14):636–641. doi: 10.1056/NEJM195604052541402. [DOI] [PubMed] [Google Scholar]
  2. CAMPBELL D. J., TURNER E. J. Aminoaciduria in a case of infantile cortical hyperostosis. Am J Clin Pathol. 1962 Oct;38:397–400. doi: 10.1093/ajcp/38.4.397. [DOI] [PubMed] [Google Scholar]
  3. Chesney R. W., Mazess R. B., Hamstra A. J., DeLuca H. F., O'Reagan S. Reduction of serum-1, 25-dihydroxyvitamin-D3 in children receiving glucocorticoids. Lancet. 1978 Nov 25;2(8100):1123–1125. doi: 10.1016/s0140-6736(78)92277-8. [DOI] [PubMed] [Google Scholar]
  4. Chesney R. W., Mazess R. B., Rose P. G., Jax D. K. Bone mineral status measured by direct photon absorptiometry in childhood renal disease. Pediatrics. 1977 Dec;60(6):864–872. [PubMed] [Google Scholar]
  5. Chesney R. W., Mazess R. B., Rose P., Jax D. K. Effect of prednisone on growth and bone mineral content in childhood glomerular disease. Am J Dis Child. 1978 Aug;132(8):768–772. doi: 10.1001/archpedi.1978.02120330040010. [DOI] [PubMed] [Google Scholar]
  6. Hyams J. S., Carey D. E. Corticosteroids and growth. J Pediatr. 1988 Aug;113(2):249–254. doi: 10.1016/s0022-3476(88)80260-9. [DOI] [PubMed] [Google Scholar]
  7. Jones J. H., Peters D. K., Morgan D. B., Coles G. A., Mallick N. P. Observations on calcium metabolism in the nephrotic syndrome. Q J Med. 1967 Jul;36(143):301–320. [PubMed] [Google Scholar]
  8. Kahn B., Straub C. P., Robbins P. J., Wellman H. N., Seltzer R. A., Telles N. C. Retention of radiostrontium, strontium, calcium, and phosphorus by infants. Appendix A-H. Pediatrics. 1969 Apr;43(4):733–756. [PubMed] [Google Scholar]
  9. Kimberg D. V., Baerg R. D., Gershon E., Graudusius R. T. Effect of cortisone treatment on the active transport of calcium by the small intestine. J Clin Invest. 1971 Jun;50(6):1309–1321. doi: 10.1172/JCI106610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Klein R. G., Arnaud S. B., Gallagher J. C., Deluca H. F., Riggs B. L. Intestinal calcium absorption in exogenous hypercortisonism. Role of 25-hydroxyvitamin D and corticosteroid dose. J Clin Invest. 1977 Jul;60(1):253–259. doi: 10.1172/JCI108762. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MANSON G., JOHNSTON J. A. STUDIES IN RHEUMATIC FEVER. IV. ATTEMPTS TO OFFSET THE CALCIUM LOSSES INCIDENTAL TO STEROID THERAPY. Am J Dis Child. 1965 Jun;109:483–488. [PubMed] [Google Scholar]
  12. Mitchell I., Barr D. G., Pocock S. J. Catch-up growth in cortisone-treated rats: effects of calcium and vitamin D. Pediatr Res. 1978 Dec;12(12):1105–1111. doi: 10.1203/00006450-197812000-00001. [DOI] [PubMed] [Google Scholar]
  13. Morris H. G. Growth and skeletal maturation in asthmatic children: effect of corticosteroid treatment. Pediatr Res. 1975 Jul;9(7):579–583. doi: 10.1203/00006450-197507000-00005. [DOI] [PubMed] [Google Scholar]
  14. O'Regan S., Chesney R. W., Hamstra A., Eisman J. A., O'Gorman A. M., Deluca H. F. Reduced serum 1,25-(OH)2 vitamin D3 levels in prednisone-treated adolescents with systemic lupus erythematosus. Acta Paediatr Scand. 1979 Jan;68(1):109–111. doi: 10.1111/j.1651-2227.1979.tb04969.x. [DOI] [PubMed] [Google Scholar]
  15. Peck W. A., Brandt J., Miller I. Hydrocortisone-induced inhibition of protein synthesis and uridine incorporation in isolated bone cells in vitro. Proc Natl Acad Sci U S A. 1967 Jun;57(6):1599–1606. doi: 10.1073/pnas.57.6.1599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pickering D., Cuddigan B. Infantile cortical hyperostosis associated with thrombocythaemia. Lancet. 1969 Aug 30;2(7618):464–465. doi: 10.1016/s0140-6736(69)90168-8. [DOI] [PubMed] [Google Scholar]
  17. Saville P. D., Kharmosh O. Osteoporosis of rheumatoid arthritis: influence of age, sex and corticosteroids. Arthritis Rheum. 1967 Oct;10(5):423–430. doi: 10.1002/art.1780100504. [DOI] [PubMed] [Google Scholar]
  18. Seeman E., Kumar R., Hunder G. G., Scott M., Heath H., 3rd, Riggs B. L. Production, degradation, and circulating levels of 1,25-dihydroxyvitamin D in health and in chronic glucocorticoid excess. J Clin Invest. 1980 Oct;66(4):664–669. doi: 10.1172/JCI109902. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Suzuki Y., Ichikawa Y., Saito E., Homma M. Importance of increased urinary calcium excretion in the development of secondary hyperparathyroidism of patients under glucocorticoid therapy. Metabolism. 1983 Feb;32(2):151–156. doi: 10.1016/0026-0495(83)90221-4. [DOI] [PubMed] [Google Scholar]
  20. Wacker W. E., Parisi A. F. Magnesium metabolism. N Engl J Med. 1968 Mar 21;278(12):658–663. doi: 10.1056/NEJM196803212781205. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES