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. 1992 Apr;67(4):482–487. doi: 10.1136/adc.67.4.482

Respiratory status and allergy after bronchiolitis.

M Murray 1, M S Webb 1, C O'Callaghan 1, A S Swarbrick 1, A D Milner 1
PMCID: PMC1793348  PMID: 1580676

Abstract

As part of a long term prospective study, 73 children who had been admitted to hospital with viral bronchiolitis as infants, were reviewed 5.5 years later and compared with a carefully matched control group. In the postbronchiolitis group, there was a highly significant increase in respiratory symptoms including wheezing (42.5% v 15.0%, relative risk = 2.8). Although atopy in the family was not significantly increased in the index group, personal atopy was more prevalent. However, personal atopy was not significantly more prevalent in the symptomatic postbronchiolitis, compared with those who were symptom free, and so did not account for the high prevalence of postbronchiolitis wheezing in this cohort. In addition, in a stepwise logistic regressional model, bronchiolitis remained a significant predictor of wheezing after adjusting for potential confounding variables, including atopy. Bronchial responsiveness to histamine was significantly increased in the index group. However, no significant relationship of positive tests to wheezing could be demonstrated, and a high rate of positive responses was noted in the controls.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carlsen K. H., Larsen S., Bjerve O., Leegaard J. Acute bronchiolitis: predisposing factors and characterization of infants at risk. Pediatr Pulmonol. 1987 May-Jun;3(3):153–160. doi: 10.1002/ppul.1950030308. [DOI] [PubMed] [Google Scholar]
  2. Carlsen K. H., Larsen S., Orstavik I. Acute bronchiolitis in infancy. The relationship to later recurrent obstructive airways disease. Eur J Respir Dis. 1987 Feb;70(2):86–92. [PubMed] [Google Scholar]
  3. Cockcroft D. W., Killian D. N., Mellon J. J., Hargreave F. E. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy. 1977 May;7(3):235–243. doi: 10.1111/j.1365-2222.1977.tb01448.x. [DOI] [PubMed] [Google Scholar]
  4. Colley J. R., Douglas J. W., Reid D. D. Respiratory disease in young adults: influence of early childhood lower respiratory tract illness, social class, air pollution, and smoking. Br Med J. 1973 Jul 28;3(5873):195–198. doi: 10.1136/bmj.3.5873.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Duiverman E. J., Neijens H. J., van Strik R., Affourtit M. J., Kerrebijn K. F. Lung function and bronchial responsiveness in children who had infantile bronchiolitis. Pediatr Pulmonol. 1987 Jan-Feb;3(1):38–44. doi: 10.1002/ppul.1950030111. [DOI] [PubMed] [Google Scholar]
  6. Gurwitz D., Mindorff C., Levison H. Increased incidence of bronchial reactivity in children with a history of bronchiolitis. J Pediatr. 1981 Apr;98(4):551–555. doi: 10.1016/s0022-3476(81)80758-5. [DOI] [PubMed] [Google Scholar]
  7. Hampton J. R. Should every survivor of a heart attack be given a beta-blocker? Part I. Evidence from clinical trials. Br Med J (Clin Res Ed) 1982 Jul 3;285(6334):33–36. doi: 10.1136/bmj.285.6334.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Henry R. L., Hodges I. G., Milner A. D., Stokes G. M. Respiratory problems 2 years after acute bronchiolitis in infancy. Arch Dis Child. 1983 Sep;58(9):713–716. doi: 10.1136/adc.58.9.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kattan M., Keens T. G., Lapierre J. G., Levison H., Bryan A. C., Reilly B. J. Pulmonary function abnormalities in symptom-free children after bronchiolitis. Pediatrics. 1977 May;59(5):683–688. [PubMed] [Google Scholar]
  10. Laing I., Reidel F., Yap P. L., Simpson H. Atopy predisposing to acute bronchiolitis during an epidemic of respiratory syncytial virus. Br Med J (Clin Res Ed) 1982 Apr 10;284(6322):1070–1072. doi: 10.1136/bmj.284.6322.1070. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. McConnochie K. M., Roghmann K. J. Bronchiolitis as a possible cause of wheezing in childhood: new evidence. Pediatrics. 1984 Jul;74(1):1–10. [PubMed] [Google Scholar]
  12. McConnochie K. M., Roghmann K. J. Wheezing at 8 and 13 years: changing importance of bronchiolitis and passive smoking. Pediatr Pulmonol. 1989;6(3):138–146. doi: 10.1002/ppul.1950060303. [DOI] [PubMed] [Google Scholar]
  13. Mok J. Y., Simpson H. Symptoms, atopy, and bronchial reactivity after lower respiratory infection in infancy. Arch Dis Child. 1984 Apr;59(4):299–305. doi: 10.1136/adc.59.4.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pullan C. R., Hey E. N. Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy. Br Med J (Clin Res Ed) 1982 Jun 5;284(6330):1665–1669. doi: 10.1136/bmj.284.6330.1665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rooney J. C., Williams H. E. The relationship between proved viral bronchiolitis and subsequent wheezing. J Pediatr. 1971 Nov;79(5):744–747. doi: 10.1016/s0022-3476(71)80385-2. [DOI] [PubMed] [Google Scholar]
  16. Rylander E., Eriksson M., Freyschuss U. Risk factors for occasional and recurrent wheezing after RSV infection in infancy. Acta Paediatr Scand. 1988 Sep;77(5):711–715. doi: 10.1111/j.1651-2227.1988.tb10735.x. [DOI] [PubMed] [Google Scholar]
  17. Samet J. M., Tager I. B., Speizer F. E. The relationship between respiratory illness in childhood and chronic air-flow obstruction in adulthood. Am Rev Respir Dis. 1983 Apr;127(4):508–523. doi: 10.1164/arrd.1983.127.4.508. [DOI] [PubMed] [Google Scholar]
  18. Sims D. G., Downham M. A., Gardner P. S., Webb J. K., Weightman D. Study of 8-year-old children with a history of respiratory syncytial virus bronchiolitis in infancy. Br Med J. 1978 Jan 7;1(6104):11–14. doi: 10.1136/bmj.1.6104.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sly P. D., Hibbert M. E. Childhood asthma following hospitalization with acute viral bronchiolitis in infancy. Pediatr Pulmonol. 1989;7(3):153–158. doi: 10.1002/ppul.1950070307. [DOI] [PubMed] [Google Scholar]
  20. Tipton W. R. Evaluation of skin testing in the diagnosis of IgE-mediated disease. Pediatr Clin North Am. 1983 Oct;30(5):785–793. doi: 10.1016/s0031-3955(16)34464-9. [DOI] [PubMed] [Google Scholar]
  21. Twiggs J. T., Larson L. A., O'Connell E. J., Ilstrup D. M. Respiratory syncytial virus infection: ten-year follow-up. Clin Pediatr (Phila) 1981 Mar;20(3):187–190. doi: 10.1177/000992288102000303. [DOI] [PubMed] [Google Scholar]
  22. WITTIG H. J., GLASER J. The relationship between bronchiolitis and childhood asthma; a follow-up study of 100 cases of bronchiolitis. J Allergy. 1959 Jan-Feb;30(1):19–23. doi: 10.1016/0021-8707(59)90054-1. [DOI] [PubMed] [Google Scholar]
  23. Webb M. S., Henry R. L., Milner A. D., Stokes G. M., Swarbrick A. S. Continuing respiratory problems three and a half years after acute viral bronchiolitis. Arch Dis Child. 1985 Nov;60(11):1064–1067. doi: 10.1136/adc.60.11.1064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Zweiman B., Schoenwetter W. F., Pappano J. E., Jr, Tempest B., Hildreth E. A. Patterns of allergic respiratory disease in children with a past history of bronchiolitis. J Allergy Clin Immunol. 1971 Nov;48(5):283–289. doi: 10.1016/0091-6749(71)90029-7. [DOI] [PubMed] [Google Scholar]

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