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. 1997 Aug;179(15):4949–4952. doi: 10.1128/jb.179.15.4949-4952.1997

Characterization of a periplasmic protein involved in iron utilization of Actinobacillus actinomycetemcomitans.

P T Willemsen 1, I Vulto 1, M Boxem 1, J de Graaff 1
PMCID: PMC179347  PMID: 9244288

Abstract

The periodontopathic bacterium Actinobacillus actinomycetemcomitans possesses a 35-kDa periplasmic iron-repressible protein. Its regulation is mediated by the Fur protein, as was inferred from the Fur-binding consensus sequence at the -35 position of the gene for the 35-kDa protein and from the relaxed expression of the gene in a mutant with an altered Fur-binding sequence. The 35-kDa protein, designated AfuA, has strong homology to HitA and FbpA of Haemophilus influenzae and Neisseria meningitidis, respectively, which serve as periplasmic iron transport proteins.

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Selected References

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