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. 1993 Mar;68(3):356–359. doi: 10.1136/adc.68.3.356

Treatment of severe steroid dependent preschool asthma with nebulised budesonide suspension.

P Ilangovan 1, S Pedersen 1, S Godfrey 1, K Nikander 1, N Noviski 1, J O Warner 1
PMCID: PMC1793871  PMID: 8466238

Abstract

The steroid sparing effect of nebulised budesonide suspension was assessed in a double blind placebo controlled parallel group study of 36 preschool children with severe asthma who were dependent on treatment with oral steroids. Nebulised budesonide suspension significantly reduced the requirement for treatment with oral steroids, and produced a marked improvement in overall health as scored on a visual analogue scale during the clinic visits. This study shows a significant step forward in the prophylactic treatment of asthma in children under the age of 3 years, in whom the efficacy of many other nebulised treatments has been questioned.

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Selected References

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  1. Balfour-Lynn L. Growth and childhood asthma. Arch Dis Child. 1986 Nov;61(11):1049–1055. doi: 10.1136/adc.61.11.1049. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carlsen K. H., Leegaard J., Larsen S., Orstavik I. Nebulised beclomethasone dipropionate in recurrent obstructive episodes after acute bronchiolitis. Arch Dis Child. 1988 Dec;63(12):1428–1433. doi: 10.1136/adc.63.12.1428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Connolly N., Godfrey S. Assessment of the child with asthma. J Asthma Res. 1970 Sep;8(1):31–36. doi: 10.3109/02770907009105028. [DOI] [PubMed] [Google Scholar]
  4. Godfrey S., Avital A., Rosler A., Mandelberg A., Uwyyed K. Nebulised budesonide in severe infantile asthma. Lancet. 1987 Oct 10;2(8563):851–852. doi: 10.1016/s0140-6736(87)91033-6. [DOI] [PubMed] [Google Scholar]
  5. Henry R. L., Hiller E. J., Milner A. D., Hodges I. G., Stokes G. M. Nebulised ipratropium bromide and sodium cromoglycate in the first two years of life. Arch Dis Child. 1984 Jan;59(1):54–57. doi: 10.1136/adc.59.1.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kewley G. D. Possible association between beclomethasone diproprionate aerosol and cataracts. Aust Paediatr J. 1980 Jun;16(2):117–118. doi: 10.1111/j.1440-1754.1980.tb01276.x. [DOI] [PubMed] [Google Scholar]
  7. Law C. M., Marchant J. L., Honour J. W., Preece M. A., Warner J. O. Nocturnal adrenal suppression in asthmatic children taking inhaled beclomethasone dipropionate. Lancet. 1986 Apr 26;1(8487):942–944. doi: 10.1016/s0140-6736(86)91045-7. [DOI] [PubMed] [Google Scholar]
  8. Lenney W., Milner A. D. At what age do bronchodilator drugs work? Arch Dis Child. 1978 Jul;53(7):532–535. doi: 10.1136/adc.53.7.532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lødrup Carlsen K. C., Nikander K., Carlsen K. H. How much nebulised budesonide reaches infants and toddlers? Arch Dis Child. 1992 Sep;67(9):1077–1079. doi: 10.1136/adc.67.9.1077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. O'Callaghan C., Milner A. D., Swarbrick A. Paradoxical deterioration in lung function after nebulised salbutamol in wheezy infants. Lancet. 1986 Dec 20;2(8521-22):1424–1425. doi: 10.1016/s0140-6736(86)92735-2. [DOI] [PubMed] [Google Scholar]
  11. O'Callaghan C. Particle size of beclomethasone dipropionate produced by two nebulisers and two spacing devices. Thorax. 1990 Feb;45(2):109–111. doi: 10.1136/thx.45.2.109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Pedersen W., Prahl P. Jet-nebulized beclomethasone dipropionate in the management of bronchial asthma. Topical steroids for asthmatic children younger than 4 years. Allergy. 1987 May;42(4):272–275. doi: 10.1111/j.1398-9995.1987.tb02209.x. [DOI] [PubMed] [Google Scholar]
  13. Prendiville A., Green S., Silverman M. Paradoxical response to nebulised salbutamol in wheezy infants, assessed by partial expiratory flow-volume curves. Thorax. 1987 Feb;42(2):86–91. doi: 10.1136/thx.42.2.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Shapiro G. G., Izu A. E., Furukawa C. T., Pierson W. E., Bierman C. W. Short-term double-blind evaluation of flunisolide aerosol for steroid-dependent asthmatic children and adolescents. Chest. 1981 Dec;80(6):671–675. doi: 10.1378/chest.80.6.671. [DOI] [PubMed] [Google Scholar]
  15. Storr J., Lenney C. A., Lenney W. Nebulised beclomethasone dipropionate in preschool asthma. Arch Dis Child. 1986 Mar;61(3):270–273. doi: 10.1136/adc.61.3.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Van Bever H. P., Schuddinck L., Wojciechowski M., Stevens W. J. Aerosolized budesonide in asthmatic infants: a double blind study. Pediatr Pulmonol. 1990;9(3):177–180. doi: 10.1002/ppul.1950090310. [DOI] [PubMed] [Google Scholar]
  17. de Jongste J. C., Duiverman E. J. Nebulised budesonide in severe childhood asthma. Lancet. 1989 Jun 17;1(8651):1388–1388. doi: 10.1016/s0140-6736(89)92831-6. [DOI] [PubMed] [Google Scholar]

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